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Page: 12345 of 5

• Research PaperVolume 17, Issue 8pp 2079-2088

  What is the clinical evidence to support off-label rapamycin therapy in healthy adults?

  Relevance score: 0.00

  Jacob M. Hands, Michael S. Lustgarten, Leigh A. Frame, Bradley Rosen

  Keywords: rapamycin, aging, mTOR

  Published in Aging on August 7, 2025

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• Research PaperVolume 17, Issue 4pp 908-936

  Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results

  Relevance score: 0.00

  Mauricio Moel, Girish Harinath, Virginia Lee, Andy Nyquist, Stefanie L. Morgan, Anar Isman, Sajad Zalzala

  Keywords: rapamycin, aging, healthspan, longevity, geroscience

  Published in Aging on April 4, 2025

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• Priority ReviewVolume 17, Issue 1pp 1-15

  Mikhail ‘Misha’ Blagosklonny’s enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin

  Relevance score: 0.00

  David A. Barzilai

  Keywords: rapamycin, longevity medicine, healthspan, geroscience, hyperfunction

  Published in Aging on January 12, 2025

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• ReviewVolume 15, Issue 4pp 905-913

  Cellular senescence: when growth stimulation meets cell cycle arrest

  Relevance score: 0.00

  Mikhail V. Blagosklonny

  Keywords: rapamycin, mTOR, hyperfunction theory of aging, cell volume and enlargement, gerogenic conversion

  Published in Aging on February 19, 2023

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• Research PaperVolume 14, Issue 22pp 9200-9209

  Rapamycin improves the quality and developmental competence of in vitro matured oocytes in aged mice and humans

  Relevance score: 0.00

  Qiyu Yang, Juan Hu, Meng Wang, Na Guo, Liu Yang, Qingsong Xi, Lixia Zhu, Lei Jin

  Keywords: rapamycin, in vitro maturation, oocyte quality, aged population, DNA damage

  Published in Aging on November 26, 2022

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• Priority Research PaperVolume 12, Issue 18pp 17786-17799

  Rapamycin maintains NAD⁺/NADH redox homeostasis in muscle cells

  Relevance score: 0.00

  Zhigang Zhang, He N. Xu, Siyu Li, Antonio Davila Jr, Karthikeyani Chellappa, James G. Davis, Yuxia Guan, David W. Frederick, Weiqing Chu, Huaqing Zhao, Lin Z. Li, Joseph A. Baur

  Keywords: rapamycin, optical redox imaging, aging, NAD⁺/NADH ratio, redox state

  Published in Aging on September 22, 2020

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• EditorialVolume 12, Issue 15pp 15184-15185

  Rapamycin for aging stem cells

  Relevance score: 0.00

  William S. Hambright, Marc J. Philippon, Johnny Huard

  Keywords: rapamycin, aging, stem cells, progeria

  Published in Aging on August 4, 2020

• Research PaperVolume 12, Issue 6pp 5152-5167

  Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis

  Relevance score: 0.00

  Jiapeng Bao, Zhonggai Chen, Langhai Xu, Lidong Wu, Yan Xiong

  Keywords: interleukin 18, osteoarthritis, chondrocyte apoptosis, rapamycin, mTOR

  Published in Aging on March 17, 2020

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• EditorialVolume 12, Issue 5pp 4050-4051

  Transient and late-life rapamycin for healthspan extension

  Relevance score: 0.00

  Ellen K. Quarles, Peter S. Rabinovitch

  Keywords: rapamycin, aging, healthspan, persistence, intermittent

  Published in Aging on March 12, 2020

• CommentaryVolume 11, Issue 24pp 12822-12826

  Rapamycin for the aging skin

  Relevance score: 0.00

  Mikhail V. Blagosklonny

  Keywords: rapamycin, mTOR, cream, topical, anti-aging, cosmetics, patents

  Published in Aging on December 27, 2019

• Research PerspectiveVolume 11, Issue 19pp 8048-8067

  Rapamycin for longevity: opinion article

  Relevance score: 0.00

  Mikhail V. Blagosklonny

  Keywords: rapamycin, rapalogs, metformin, aging, anti-aging, fasting, lifespan, health span

  Published in Aging on October 4, 2019

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• EditorialVolume 11, Issue 16pp 5868-5870

  Rapamycin protects aging muscle

  Relevance score: 0.00

  Huibin Tang, Joseph B. Shrager, Daniel Goldman

  Keywords: rapamycin, mTORC1, aging, skeletal muscle, oxidative stress

  Published in Aging on August 27, 2019

• Research PaperVolume 11, Issue 10pp 3238-3249

  Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation

  Relevance score: 0.00

  Steve Horvath, Ake T. Lu, Howard Cohen, Ken Raj

  Keywords: epigenetic ageing, Rapamycin

  Published in Aging on May 26, 2019

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• Research PaperVolume 11, Issue 1pp 185-208

  Rapamycin-mediated mTOR inhibition impairs silencing of sex chromosomes and the pachytene piRNA pathway in the mouse testis

  Relevance score: 0.00

  Zhiping Zhu, Qiuling Yue, Jie Xie, Shuya Zhang, Wenxiu He, Shun Bai, Suwen Tian, Yingwen Zhang, Mengneng Xiong, Zheng Sun, Chaoyang Huang, Yuebei Li, Ke Zheng, Lan Ye

  Keywords: rapamycin, mTOR inhibition, germ cells, meiosis, meiotic silencing of sex chromosomes

  Published in Aging on January 13, 2019

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• Research PaperVolume 10, Issue 1pp 131-143

  Rapamycin prevents the intervertebral disc degeneration via inhibiting differentiation and senescence of annulus fibrosus cells

  Relevance score: 0.00

  Changhong Gao, Bin Ning, Chenglin Sang, Ying Zhang

  Keywords: intervertebral disc, annulus fibrosus, cellular senescence, rapamycin, bleomycin

  Published in Aging on January 18, 2018

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• Research PaperVolume 8, Issue 11pp 3120-3130

  Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes

  Relevance score: 0.00

  Peter C. Reifsnyder, Kevin Flurkey, Austen Te, David E. Harrison

  Keywords: rapamycin, type 2 diabetes, strain survey, insulin sensitivity, pancreatic insulin content

  Published in Aging on November 30, 2016

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• EditorialVolume 8, Issue 5pp 833-834

  Rapamycin slows down gut aging

  Relevance score: 0.00

  Uma Gaur, Xiaolan Fan, Mingyao Yang

  Keywords: rapamycin, gut homeostasis, intestinal stem cell, Drosophila

  Published in Aging on May 12, 2016

• Research PaperVolume 8, Issue 5pp 1102-1114

  Rapamycin reverses the senescent phenotype and improves immuno-regulation of mesenchymal stem cells from MRL/lpr mice and systemic lupus erythematosus patients through inhibition of the mTOR signaling pathway

  Relevance score: 0.00

  Zhifeng Gu, Wei Tan, Juan Ji, Guijian Feng, Yan Meng, Zhanyun Da, Genkai Guo, Yunfei Xia, Xinhang Zhu, Guixiu Shi, Chun Cheng

  Keywords: rapamycin (RAPA), mesenchymal stem cells (MSCs), systemic lupus erythematosus (SLE), senescence, immunoregulation

  Published in Aging on April 2, 2016

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• Research PaperVolume 8, Issue 4pp 769-776

  Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats

  Relevance score: 0.00

  Qian-Li Xue, Huanle Yang, Hui-Fen Li, Peter M. Abadir, Tyesha N. Burks, Lauren G. Koch, Steven L. Britton, Joshua Carlson, Laura Chen, Jeremy D. Walston, Sean X. Leng

  Keywords: rapamycin, low capacity runner rats, aging, healthspan, physical function

  Published in Aging on March 19, 2016

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• Research PaperVolume 8, Issue 2pp 314-327

  Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

  Relevance score: 0.00

  Ying Ann Chiao, Stephen C. Kolwicz, Nathan Basisty, Arni Gagnidze, Julia Zhang, Haiwei Gu, Danijel Djukovic, Richard P. Beyer, Daniel Raftery, Michael MacCoss, Rong Tian, Peter S. Rabinovitch

  Keywords: cardiac aging, rapamycin, autophagy, mitochondrial metabolism, substrate utilization

  Published in Aging on February 11, 2016

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