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Volume 12, Issue 6

March 31, 2020pp 4682—5587

About the Cover

The cover features Figure 8 "A model depicting how endogenous nuclear DNA damage activates NF-κB via an ATM- and NEMO-dependent mechanism to drive cellular senescence and senescence-associated secretory phenotype (SASP)“ from Zhao et al.

Editorials

Nuclear protein export pathway in aging therapeutics

Bulmaro Cisneros, Ian García-Aguirre

https://doi.org/10.18632/aging.102948pp 4682—4684

Prometheus revisited: liver homeostasis and repair

Tianliang Sun, Stefano Annunziato, Jan S. Tchorz

https://doi.org/10.18632/aging.102957pp 4685—4687

Priority Research Paper

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

Jing Zhao, Lei Zhang, Aiping Lu, Yingchao Han, Debora Colangelo, Christina Bukata, Alex Scibetta, Matthew J. Yousefzadeh, Xuesen Li, Aditi U. Gurkar, Sara J. McGowan, Luise Angelini, Ryan O’Kelly, Hongshuai Li, Lana Corbo, Tokio Sano, Heather Nick, Enrico Pola, Smitha P.S. Pilla, Warren C. Ladiges, Nam Vo, Johnny Huard, Laura J. Niedernhofer, Paul D. Robbins

https://doi.org/10.18632/aging.102863pp 4688—4710

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Research Papers

Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin

Xiaohui Xu, Xiaoyun Zhou, Zhenju Chen, Chao Gao, Luo Zhao, Yushang Cui

https://doi.org/10.18632/aging.102673pp 4711—4726

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Metformin coordinates osteoblast/osteoclast differentiation associated with ischemic osteonecrosis

See-Hyoung Park, Mi-Ae Kang, Young Jae Moon, Kyu Yun Jang, Jung Ryul Kim

https://doi.org/10.18632/aging.102796pp 4727—4741

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Genome-wide association study identifies genetic factors that modify age at onset in Machado-Joseph disease

Fulya Akçimen, Sandra Martins, Calwing Liao, Cynthia V. Bourassa, Hélène Catoire, Garth A. Nicholson, Olaf Riess, Mafalda Raposo, Marcondes C. França, João Vasconcelos, Manuela Lima, Iscia Lopes-Cendes, Maria Luiza Saraiva-Pereira, Laura B. Jardim, Jorge Sequeiros, Patrick A. Dion, Guy A. Rouleau

https://doi.org/10.18632/aging.102825pp 4742—4756

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Prognostic value of immune-related genes in the tumor microenvironment of lung adenocarcinoma and lung squamous cell carcinoma

Yan Qu, Bo Cheng, Na Shao, Yibin Jia, Qingxu Song, Bingxu Tan, Jianbo Wang

https://doi.org/10.18632/aging.102871pp 4757—4777

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Transplant of microbiota from long-living people to mice reduces aging-related indices and transfers beneficial bacteria

Yinfeng Chen, Siyuan Zhang, Bo Zeng, Jiangchao Zhao, Mingyao Yang, Mingwang Zhang, Yan Li, Qingyong Ni, De Wu, Ying Li

https://doi.org/10.18632/aging.102872pp 4778—4793

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The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes

Elisabet Cuyàs, Juan Gumuzio, Sara Verdura, Joan Brunet, Joaquim Bosch-Barrera, Begoña Martin-Castillo, Tomás Alarcón, José Antonio Encinar, Ángel G. Martin, Javier A. Menendez

https://doi.org/10.18632/aging.102887pp 4794—4814

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Clinical significance of age at diagnosis among patients with thymic epithelial tumors: a population-based study

Mina Liu, Changlu Wang, Lanting Gao, Changxing Lv, Xiaolong Fu

https://doi.org/10.18632/aging.102897pp 4815—4821

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Prediction of cognitive performance in old age from spatial probability maps of white matter lesions

Cui Zhao, Ying Liang, Ting Chen, Yihua Zhong, Xianglong Li, Jing Wei, Chunlin Li, Xu Zhang

https://doi.org/10.18632/aging.102901pp 4822—4835

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Nrf2 deficiency aggravates PM_2.5-induced cardiomyopathy by enhancing oxidative stress, fibrosis and inflammation via RIPK3-regulated mitochondrial disorder

Chenxu Ge, Linfeng Hu, Deshuai Lou, Qiang Li, Jing Feng, Yekuan Wu, Jun Tan, Minxuan Xu

https://doi.org/10.18632/aging.102906pp 4836—4865

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MiR-519d targets HER3 and can be used as a potential serum biomarker for non-small cell lung cancer

Aili Wang, Hongxia Zhang, Jinxiang Wang, Shuming Zhang, Zhenyang Xu

https://doi.org/10.18632/aging.102908pp 4866—4878

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A nine-gene signature related to tumor microenvironment predicts overall survival with ovarian cancer

Qi Ding, Shanshan Dong, Ranran Wang, Keqiang Zhang, Hui Wang, Xiao Zhou, Jing Wang, Kee Wong, Ying Long, Shuai Zhu, Weigang Wang, Huayi Ren, Yong Zeng

https://doi.org/10.18632/aging.102914pp 4879—4895

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Development and validation of a nomogram for preoperative prediction of cervical lymph node involvement in thyroid microcarcinoma

Si Lu, Rongjie Zhao, Yeqin Ni, Jinwang Ding, Fuqiang Qiu, You Peng, Gang Pan, Fan Wu, Yu Zhang, Jingjing Shi, Tianhan Zhou, Dingcun Luo

https://doi.org/10.18632/aging.102915pp 4896—4906

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The neurocognitive and BDNF changes of multicomponent exercise for community-dwelling older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis

Xinyi Wang, Haiyun Wang, Zhenghui Ye, Guofei Ding, Fengli Li, Ji Ma, Wei Hua

https://doi.org/10.18632/aging.102918pp 4907—4917

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Efficacy and safety of recombinant human follicle-stimulating hormone in patients undergoing in vitro fertilization-embryo transfer

Linli Hu, Songying Zhang, Song Quan, Jieqiang Lv, Weiping Qian, Yuanhua Huang, Weiying Lu, Yingpu Sun

https://doi.org/10.18632/aging.102919pp 4918—4930

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Optimal cumulative cisplatin dose in nasopharyngeal carcinoma patients based on plasma Epstein–Barr virus DNA level after induction chemotherapy

Sai-Lan Liu, Xue-Song Sun, Li-Ting Liu, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Huan-Xin Lin, Li Yuan, Lin-Quan Tang, Ling Guo, Hai-Qiang Mai

https://doi.org/10.18632/aging.102920pp 4931—4944

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Fasting blood glucose and cerebrospinal fluid Alzheimer’s biomarkers in non-diabetic cognitively normal elders: the CABLE study

Ya-Nan Ou, Xue-Ning Shen, He-Ying Hu, Hao Hu, Zuo-Teng Wang, Wei Xu, Qiang Dong, Lan Tan, Jin-Tai Yu

https://doi.org/10.18632/aging.102921pp 4945—4952

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RNA sequencing analysis of monocrotaline-induced PAH reveals dysregulated chemokine and neuroactive ligand receptor pathways

Genfa Xiao, Tingjun Wang, Wei Zhuang, Chaoyi Ye, Li Luo, Huajun Wang, Guili Lian, Liangdi Xie

https://doi.org/10.18632/aging.102922pp 4953—4969

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Integrative analysis of DNA methylation and gene expression reveals distinct hepatocellular carcinoma subtypes with therapeutic implications

Xiaowen Huang, Chen Yang, Jilin Wang, Tiantian Sun, Hua Xiong

https://doi.org/10.18632/aging.102923pp 4970—4995

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Identification of survival-associated alternative splicing events and signatures in adrenocortical carcinoma based on TCGA SpliceSeq data

Ning Xu, Zhi-Bin Ke, Xiao-Dan Lin, Fei Lin, Shao-Hao Chen, Yu-Peng Wu, Ye-Hui Chen, Yong Wei, Qing-Shui Zheng

https://doi.org/10.18632/aging.102924pp 4996—5009

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Development of an immune-related prognostic index associated with hepatocellular carcinoma

Bo Hu, Xiao-Bo Yang, Xin-Ting Sang

https://doi.org/10.18632/aging.102926pp 5010—5030

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Expression and prognosis analysis of TET family in acute myeloid leukemia

Tingjuan Zhang, Yangli Zhao, Yangjing Zhao, Jingdong Zhou

https://doi.org/10.18632/aging.102928pp 5031—5047

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Using ESTIMATE algorithm to establish an 8-mRNA signature prognosis prediction system and identify immunocyte infiltration-related genes in Pancreatic adenocarcinoma

Zibo Meng, Dianyun Ren, Kun Zhang, Jingyuan Zhao, Xin Jin, Heshui Wu

https://doi.org/10.18632/aging.102931pp 5048—5070

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Comprehensive analysis of circular RNA profiles in skeletal muscles of aging mice and after aerobic exercise intervention

Mingwei Guo, Jin Qiu, Fei Shen, Sainan Wang, Jian Yu, Hui Zuo, Jing Yao, Sainan Xu, Tianhui Hu, Dongmei Wang, Yu Zhao, Yepeng Hu, Feixia Shen, Xinran Ma, Jian Lu, Xuejiang Gu, Lingyan Xu

https://doi.org/10.18632/aging.102932pp 5071—5090

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Time-dependent interactions of blood platelets and cancer cells, accompanied by extramedullary hematopoiesis, lead to increased platelet activation and reactivity in a mouse orthotopic model of breast cancer – implications for pulmonary and liver metastasis

Hassan Kassassir, Kamil Karolczak, Karolina M. Siewiera, Dagmara W. Wojkowska, Marcin Braun, Cezary W. Watala

https://doi.org/10.18632/aging.102933pp 5091—5120

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EMMPRIN/CD147 plays a detrimental role in clinical and experimental ischemic stroke

Anthony Patrizz, Sarah J. Doran, Anjali Chauhan, Hilda Ahnstedt, Meaghan Roy-O’Reilly, Yun-Ju Lai, Gillian Weston, Sami Tarabishy, Anita R. Patel, Rajkumar Verma, Ilene Staff, Julia K. Kofler, Jun Li, Fudong Liu, Rodney M. Ritzel, Louise D. McCullough

https://doi.org/10.18632/aging.102935pp 5121—5139

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Association between serum angiopoietin-2 concentrations and periprocedural myocardial injury in patients undergoing elective percutaneous coronary intervention

Wen Jian, Jia-Hui Guan, Wen-Bo Zheng, Chang-Hua Mo, Yu-Tao Xu, Qi-Li Huang, Chun-Mei Wei, Can Wang, Zhi-Jie Yang, Guo-Liang Yang, Chun Gui

https://doi.org/10.18632/aging.102936pp 5140—5151

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Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis

Jiapeng Bao, Zhonggai Chen, Langhai Xu, Lidong Wu, Yan Xiong

https://doi.org/10.18632/aging.102937pp 5152—5167

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Impaired brain network architecture in Cushing’s disease based on graph theoretical analysis

Can-Xin Xu, Hong Jiang, Rui-Zhe Zheng, Yu-Hao Sun, Qing-Fang Sun, Liu-Guan Bian

https://doi.org/10.18632/aging.102939pp 5168—5182

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LncRNA AGAP2-AS1 augments cell viability and mobility, and confers gemcitabine resistance by inhibiting miR-497 in colorectal cancer

Sen Hong, Zhenkun Yan, YuMei Song, MiaoMiao Bi, Shiquan Li

https://doi.org/10.18632/aging.102940pp 5183—5194

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Peroxisomal abnormalities and catalase deficiency in Hutchinson-Gilford Progeria Syndrome

Xiaojing Mao, Pratima Bharti, Abhirami Thaivalappil, Kan Cao

https://doi.org/10.18632/aging.102941pp 5195—5208

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MicroRNA-325-3p prevents sevoflurane-induced learning and memory impairment by inhibiting Nupr1 and C/EBPβ/IGFBP5 signaling in rats

Lili Xu, Qi Xu, Fang Xu, Wenxin Zhang, Qing Chen, Hui Wu, Xinzhong Chen

https://doi.org/10.18632/aging.102942pp 5209—5220

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Genetic networks in Parkinson’s and Alzheimer’s disease

Jack Kelly, Rana Moyeed, Camille Carroll, Shouqing Luo, Xinzhong Li

https://doi.org/10.18632/aging.102943pp 5221—5243

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Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition

Randall F. D’Souza, Jonathan S. T. Woodhead, Christopher P. Hedges, Nina Zeng, Junxiang Wan, Hiroshi Kumagai, Changhan Lee, Pinchas Cohen, David Cameron-Smith, Cameron J. Mitchell, Troy L. Merry

https://doi.org/10.18632/aging.102944pp 5244—5258

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Whole-transcriptome analysis reveals a potential hsa_circ_0001955/hsa_circ_0000977-mediated miRNA-mRNA regulatory sub-network in colorectal cancer

Bisha Ding, Minya Yao, Weimin Fan, Weiyang Lou

https://doi.org/10.18632/aging.102945pp 5259—5279

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m⁶A-induced lncRNA MALAT1 aggravates renal fibrogenesis in obstructive nephropathy through the miR-145/FAK pathway

Peihua Liu, Bo Zhang, Zhi Chen, Yao He, Yongchao Du, Yuhang Liu, Xiang Chen

https://doi.org/10.18632/aging.102950pp 5280—5299

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Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy

Wenwen Liu, Huiling Lin, Zhifan Mao, Lanxin Zhang, Keting Bao, Bei Jiang, Conglong Xia, Wenjun Li, Zelan Hu, Jian Li

https://doi.org/10.18632/aging.102951pp 5300—5317

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Dexmedetomidine alleviates sleep-restriction-mediated exaggeration of postoperative immunosuppression via splenic TFF2 in aged mice

Guangzhi Wang, Xiaoying Wu, Guosong Zhu, Shuangyin Han, Jiaqiang Zhang

https://doi.org/10.18632/aging.102952pp 5318—5335

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Overexpressed ITGA2 contributes to paclitaxel resistance by ovarian cancer cells through the activation of the AKT/FoxO1 pathway

Linlin Ma, Yan Sun, Dan Li, Hansong Li, Xin Jin, Dianyun Ren

https://doi.org/10.18632/aging.102954pp 5336—5351

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Metformin inhibits high glucose-induced smooth muscle cell proliferation and migration

Dong-Ming Zhou, Feng Ran, Hai-Zhen Ni, Li-Li Sun, Lun Xiao, Xiao-Qiang Li, Wen-Dong Li

https://doi.org/10.18632/aging.102955pp 5352—5361

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Delphinidin attenuates pathological cardiac hypertrophy via the AMPK/NOX/MAPK signaling pathway

Youming Chen, Zhuowang Ge, Shixing Huang, Lei Zhou, Changlin Zhai, Yuhan Chen, Qiuyue Hu, Wei Cao, Yuteng Weng, Yanyan Li

https://doi.org/10.18632/aging.102956pp 5362—5383

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N-Propargyl caffeate amide (PACA) prevents cardiac fibrosis in experimental myocardial infarction by promoting pro-resolving macrophage polarization

Yuanyuan Cheng, Dan Luo, Yingke Zhao, Jianhui Rong

https://doi.org/10.18632/aging.102959pp 5384—5398

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The therapeutic value of the SphK1-targeting microRNA-3677 in human osteosarcoma cells

Chen Yao, Jian-Wei Ruan, Yun-Rong Zhu, Fei Liu, Hui-ming Wu, Yan Zhang, Qing Jiang

https://doi.org/10.18632/aging.102961pp 5399—5410

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HDAC6 promotes sepsis development by impairing PHB1-mediated mitochondrial respiratory chain function

Shi-dong Guo, Sheng-tao Yan, Wen Li, Hong Zhou, Jian-ping Yang, Yao Yao, Mei-jia Shen, Liu-wei Zhang, Hong-Bo Zhang, Li-Chao Sun

https://doi.org/10.18632/aging.102964pp 5411—5422

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Melatonin reverses nasopharyngeal carcinoma cisplatin chemoresistance by inhibiting the Wnt/β-catenin signaling pathway

Jian Zhang, Tao Xie, Xi Zhong, Hua-Li Jiang, Rong Li, Bai-Yao Wang, Xiao-Ting Huang, Bo-Hong Cen, Ya-Wei Yuan

https://doi.org/10.18632/aging.102968pp 5423—5438

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Identification of hub genes in hepatocellular carcinoma using integrated bioinformatic analysis

Shengni Hua, Zhonghua Ji, Yingyao Quan, Meixiao Zhan, Hao Wang, Wei Li, Yong Li, Xu He, Ligong Lu

https://doi.org/10.18632/aging.102969pp 5439—5468

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Intranasal delivery of 9-cis retinoic acid reduces beta-amyloid deposition via inhibiting astrocyte-mediated inflammation

Hong Zhao, Shuo Li, Zhuo Li, Shuo Yang, Dandan Li, Jiaolin Zheng, Hongmei Gao, Ling Yun, YingLi Gu, Longxuan Li, Jing Zhao, Yuan Fu

https://doi.org/10.18632/aging.102970pp 5469—5478

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Prognostic values of immune scores and immune microenvironment-related genes for hepatocellular carcinoma

Peng-lei Ge, Shi-fang Li, Wei-wei Wang, Chun-bo Li, Yu-bin Fu, Zheng-kai Feng, Lin Li, Gong Zhang, Zhi-qiang Gao, Xiao-wei Dang, Yang Wu

https://doi.org/10.18632/aging.102971pp 5479—5499

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The association of calcium intake with osteoporotic vertebral fractures in a large Chinese cohort

Ling Wang, Lu Yin, Xiaoguang Cheng, Kai Li, Yuebo Wang, Yong Zhang, Yang-yang Duanmu, Xiaoyun Liu, Guijuan Deng, Yang Wang, Nicola Veronese, Wei Li, Wei Tian, PURE China CASH study team

https://doi.org/10.18632/aging.102974pp 5500—5515

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Microarray analysis of verbenalin-treated human amniotic epithelial cells reveals therapeutic potential for Alzheimer’s Disease

Farhana Ferdousi, Shinji Kondo, Kazunori Sasaki, Yoshiaki Uchida, Nobuhiro Ohkohchi, Yun-Wen Zheng, Hiroko Isoda

https://doi.org/10.18632/aging.102985pp 5516—5538

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Reviews

Gut microbiota and pro/prebiotics in Alzheimer’s disease

Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J. Czuczwar

https://doi.org/10.18632/aging.102930pp 5539—5550

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Aging-associated alterations in epidermal function and their clinical significance

Zhen Wang, Mao-Qiang Man, Tienan Li, Peter M. Elias, Theodora M. Mauro

https://doi.org/10.18632/aging.102946pp 5551—5565

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Research Perspective

Perspectives of Homo sapiens lifespan extension: focus on external or internal resources?

Vladimir P. Skulachev, Gregory A. Shilovsky, Tatyana S. Putyatina, Nikita A. Popov, Alexander V. Markov, Maxim V. Skulachev, Victor A. Sadovnichii

https://doi.org/10.18632/aging.102981pp 5566—5584

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Corrections

Correction for: Mitochondria and aging in older individuals: an analysis of DNA methylation age metrics, leukocyte telomere length, and mitochondrial DNA copy number in the VA normative aging study

Jacopo Dolcini, Haotian Wu, Jamaji C. Nwanaji-Enwerem, Marianthi-Anna Kioumourtozlogu, Akin Cayir, Marco Sanchez-Guerra, Pantel Vokonas, Joel Schwarz, Andrea A. Baccarelli

https://doi.org/10.18632/aging.102962pp 5585—5586

Correction for: Ligustilide improves aging-induced memory deficit by regulating mitochondrial related inflammation in SAMP8 mice

Wen-Li Zhu, Jia-Yi Zheng, Wei-Wu Cai, Zhao Dai, Ben-Yue Li, Ting-Ting Xu, Hao-Fei Liu, Xiao-Qi Liu, Su-Fen Wei, Yi Luo, Hong Wang, Hua-Feng Pan, Qi Wang, Shi-Jie Zhang

https://doi.org/10.18632/aging.102998pp 5587