Research Paper|Volume 12, Issue 6|pp 4778—4793

Transplant of microbiota from long-living people to mice reduces aging-related indices and transfers beneficial bacteria

Yinfeng Chen¹, Siyuan Zhang¹, Bo Zeng¹, Jiangchao Zhao², Mingyao Yang¹, Mingwang Zhang¹, Yan Li¹, Qingyong Ni¹, De Wu³, Ying Li¹

¹Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China
²Department of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USA
³Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, China

Received: December 20, 2019Accepted: February 20, 2020Published: March 16, 2020

https://doi.org/10.18632/aging.102872

Copyright © 2020 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A close relationship between age and gut microbiota exists in invertebrates and vertebrates, including humans. Long-living people are a model for studying healthy aging; they also have a distinctive microbiota structure. The relationship between the microbiota of long-living people and aging phenotype remains largely unknown. Herein, the feces of long-living people were transplanted into mice, which were then examined for aging-related indices and beneficial bacteria. Mice transplanted with fecal matter from long-living people (L group) had greater α diversity, more probiotic genera (Lactobacillus and Bifidobacterium), and short-chain fatty acid producing genera (Roseburia, Faecalibacterium, Ruminococcus, Coprococcus) than the control group. L group mice also accumulated less lipofuscin and β-galactosidase and had longer intestinal villi. This study indicates the effects that the gut microbiota from long-living people have on healthy aging.