Cellular senescence: when growth stimulation meets cell cycle arrest

Mikhail V. Blagosklonny¹

¹Roswell Park Comprehensive Cancer Center, NY 14263, USA

Received: December 1, 2022Accepted: February 16, 2023Published: February 19, 2023

https://doi.org/10.18632/aging.204543

Copyright: © 2023 Blagosklonny This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

At the very moment of cell-cycle arrest, the cell is not senescent yet. For several days in cell culture, the arrested cell is acquiring a senescent phenotype. What is happening during this geroconversion? Cellular enlargement (hypertrophy) and hyperfunctions (lysosomal and hyper-secretory) are hallmarks of geroconversion.