Volume 8, Issue 4

April 2016pp 565—832

About the Cover

The cover for issue 4 of Aging features Figure 2A, 'Perlecan expression influences the keratin 15‐positive cell population fate in the epidermis of aging skin' from Dos Santos et al.

Letter to the Editor

Oncogenic epigenetic control

Gary S. Stein, Terri L. Messier, Jonathan A. R. Gordon, Joseph R. Boyd, Coralee E. Tye, Jane B. Lian, Janet L. Stein

https://doi.org/10.18632/aging.100940pp 565—566

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Editorials

Repurposing of FDA-approved drugs against cancer – focus on metastasis

Béla Ozsvári, Rebecca Lamb, Michael P. Lisanti

https://doi.org/10.18632/aging.100941pp 567—568

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Potential targeted therapeutic approaches in liposarcoma

Deepika Kanojia, Manoj Garg, H. Phillip Koeffler

https://doi.org/10.18632/aging.100945pp 569—570

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Cyclin E1-CDK 2, a potential anticancer target

Dongdong Fang, Shuang Huang, Shi-Bing Su

https://doi.org/10.18632/aging.100946pp 571—572

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Metronomic chemotherapy for triple negative breast cancer?

Teresa Di Desidero, Robert S. Kerbel, Guido Bocci

https://doi.org/10.18632/aging.100947pp 573—574

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Reviews

Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation

Judith Miklossy, Patrick L. McGeer

https://doi.org/10.18632/aging.100921pp 575—588

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Principles of alternative gerontology

Tomasz Bilinski, Aneta Bylak, Renata Zadrag-Tecza

https://doi.org/10.18632/aging.100931pp 589—602

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Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

Giuseppa Pistritto, Daniela Trisciuoglio, Claudia Ceci, Alessia Garufi, Gabriella D'Orazi

https://doi.org/10.18632/aging.100934pp 603—619

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Research Papers

Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy

Jenna M. Bartley, Sarah J. Pan, Spencer R. Keilich, Jacob W. Hopkins, Iman M. Al-Naggar, George A. Kuchel, Laura Haynes

https://doi.org/10.18632/aging.100882pp 620—635

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Quantification of global mitochondrial DNA methylation levels and inverse correlation with age at two CpG sites

Shakhawan K. Mawlood, Lynn Dennany, Nigel Watson, John Dempster, Benjamin S. Pickard

https://doi.org/10.18632/aging.100892pp 636—641

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The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways

Davina Derous, Sharon E. Mitchell, Cara L. Green, Luonan Chen, Jing‐Dong J. Han, Yingchun Wang, Daniel E.L. Promislow, David Lusseau, John R. Speakman, Alex Douglas

https://doi.org/10.18632/aging.100895pp 642—661

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Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice

Christian Griñán-Ferré, Sara Sarroca, Aleksandra Ivanova, Dolors Puigoriol-Illamola, Fernando Aguado, Antoni Camins, Coral Sanfeliu, Mercè Pallàs

https://doi.org/10.18632/aging.100906pp 664—684

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SIRT1, 2, 3 protect mouse oocytes from postovulatory aging

Teng Zhang, Yang Zhou, Li Li, Hong-Hui Wang, Xue-Shan Ma, Wei-Ping Qian, Wei Shen, Heide Schatten, Qing-Yuan Sun

https://doi.org/10.18632/aging.100911pp 685—694

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Sex-specific effects of cytotoxic chemotherapy agents cyclophosphamide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus – an aging connection

Anna Kovalchuk, Rocio Rodriguez-Juarez, Yaroslav Ilnytskyy, Boseon Byeon, Svitlana Shpyleva, Stepan Melnyk, Igor Pogribny, Bryan Kolb, Olga Kovalchuk

https://doi.org/10.18632/aging.100920pp 697—708

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A robust neuromuscular system protects rat and human skeletal muscle from sarcopenia

Alice Pannérec, Margherita Springer, Eugenia Migliavacca, Alex Ireland, Mathew Piasecki, Sonia Karaz, Guillaume Jacot, Sylviane Métairon, Esther Danenberg, Frédéric Raymond, Patrick Descombes, Jamie S. McPhee, Jerome N. Feige

https://doi.org/10.18632/aging.100926pp 712—728

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N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice

Dalian Ding, Haiyan Jiang, Guang-Di Chen, Chantal Longo-Guess, Vijaya Prakash Krishnan Muthaiah, Cong Tian, Adam Sheppard, Richard Salvi, Kenneth R. Johnson

https://doi.org/10.18632/aging.100927pp 730—750

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Perlecan expression influences the keratin 15‐positive cell population fate in the epidermis of aging skin

Morgan Dos Santos, Anna Michopoulou, Valérie André‐Frei, Sophie Boulesteix, Christine Guicher, Guila Dayan, John Whitelock, Odile Damour, Patricia Rousselle

https://doi.org/10.18632/aging.100928pp 751—768

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Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats

Qian-Li Xue, Huanle Yang, Hui-Fen Li, Peter M. Abadir, Tyesha N. Burks, Lauren G. Koch, Steven L. Britton, Joshua Carlson, Laura Chen, Jeremy D. Walston, Sean X. Leng

https://doi.org/10.18632/aging.100929pp 769—776

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Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways

Dylan J. Dues, Emily K. Andrews, Claire E. Schaar, Alexis L. Bergsma, Megan M. Senchuk, Jeremy M. Van Raamsdonk

https://doi.org/10.18632/aging.100939pp 777—795

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Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers

Laura J. Cobb, Changhan Lee, Jialin Xiao, Kelvin Yen, Richard G. Wong, Hiromi K. Nakamura, Hemal H. Mehta, Qinglei Gao, Carmel Ashur, Derek M. Huffman, Junxiang Wan, Radhika Muzumdar, Nir Barzilai, Pinchas Cohen

https://doi.org/10.18632/aging.100943pp 796—809

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Mitotic degradation of yeast Fkh1 by the Anaphase Promoting Complex is required for normal longevity, genomic stability and stress resistance

Mackenzie E. Malo, Spike D.L. Postnikoff, Terra G. Arnason, Troy A.A. Harkness

https://doi.org/10.18632/aging.100949pp 810—830

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Errata

Erratum: A meta-analysis on age-associated changes in blood DNA methylation: results from an original analysis pipeline for Infinium 450k data

Maria Giulia Bacalini, Alessio Boattini, Davide Gentilini, Enrico Giampieri, Chiara Pirazzini, Cristina Giuliani, Elisa Fontanesi, Daniel Remondini, Miriam Capri, Alberto Del Rio, Donata Luiselli, Giovanni Vitale, Daniela Mari, Gastone Castellani, Anna Maria Di Blasio, Stefano Salvioli, Claudio Franceschi, Paolo Garagnani

https://doi.org/10.18632/aging.100915pp 831

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Erratum: PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity

Aleksandra Dabrowska, Jose Luis Luis Venero, Ryota Iwasawa, Mohammed-khair Hankir, Sunniyat Rahman, Alan Boobis, Nabil Hajji

https://doi.org/10.18632/aging.100955pp 832

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