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• Research PaperVolume 15, Issue 18pp 9293-9309

  Biomedical generative pre-trained based transformer language model for age-related disease target discovery

  Relevance score: 0.00

  Diana Zagirova, Stefan Pushkov, Geoffrey Ho Duen Leung, Bonnie Hei Man Liu, Anatoly Urban, Denis Sidorenko, Aleksandr Kalashnikov, Ekaterina Kozlova, Vladimir Naumov, Frank W. Pun, Ivan V. Ozerov, Alex Aliper, Alex Zhavoronkov

  Keywords: transformers, deep learning, therapeutic target discovery, aging biomarkers, human aging

  Published in Aging on September 22, 2023

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• Research PaperVolume 11, Issue 21pp 9811-9828

  The TORC1 inhibitor Nprl2 protects age-related digestive function in Drosophila

  Relevance score: 0.00

  Junmeng Xi, Jiadong Cai, Yang Cheng, Yuanyuan Fu, Wanhong Wei, Zhenbo Zhang, Ziheng Zhuang, Yue Hao, Mary A. Lilly, Youheng Wei

  Keywords: Target of rapamycin complex 1 (TORC1), Nprl2, Drosophila, crop, gut

  Published in Aging on November 11, 2019

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• EditorialVolume 10, Issue 1pp 11-12

  Targeting LSD2 in breast cancer

  Relevance score: 0.00

  Yi Huang, Yongmei Yin, Min Sun

  Keywords: LSD2, breast cancer, LSD1, cancer stem cell, tumorigenesis, small molecule inhibitor, target therapy

  Published in Aging on January 20, 2018

• EditorialVolume 8, Issue 10pp 2258-2259

  Combinations of targeted therapies in human cancers

  Relevance score: 0.00

  Didier Decaudin, Christophe Le Tourneau

  Keywords: targeted therapies, human cancers, preclinical studies, clinical trials

  Published in Aging on October 26, 2016

• Research PaperVolume 6, Issue 5pp 390-398

  Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration

  Relevance score: 0.00

  Sahar Emran, Mingyao Yang, Xiaoli He, Jelle Zandveld, Matthew D. W. Piper

  Keywords: Drosophila melanogaster, rapamycin, target of rapamycin signalling, phenotyping, lifespan, stress response, essential amino acids

  Published in Aging on May 19, 2014

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• Research PaperVolume 16, Issue 12pp 10380-10401

  Therapeutic targets of formononetin for treating prostate cancer at the single-cell level

  Relevance score: 0.00

  Jiawei Li, Zhaoquan Huang, Ping Wang, Rong Li, Li Gao, Keng Po Lai

  Keywords: network pharmacology, formononetin, prostate cancer, single cell, therapeutic targets, immune response, heterogeneity

  Published in Aging on June 13, 2024

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• Research PaperVolume 11, Issue 12pp 4032-4049

  Long-time qingyan formula extract treatment exerts estrogenic activities on reproductive tissues without side effects in ovariectomized rats and via active ER to ERE-independent gene regulation

  Relevance score: 0.00

  Hong-Xia Zheng, Yuan Zhao, Ying Xu, Zi-Jia Zhang, Jing-jing Zhu, Yuan-Fang Fan, Na Lin

  Keywords: reproductive target tissue, estrogenic effect, estrogen receptors, estrogen receptor antagonist ICI182,780

  Published in Aging on June 19, 2019

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• Research PaperVolume 10, Issue 7pp 1666-1681

  Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2

  Relevance score: 0.00

  Eva Latorre, Roberta Torregrossa, Mark E. Wood, Matthew Whiteman, Lorna W. Harries

  Keywords: splicing factors, senescence, HS ₂, AP39, AP123, RT01, mitochondria-targeting, persulfide, perthiol

  Published in Aging on July 19, 2018

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• Research PaperVolume 7, Issue 7pp 475-485

  Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice

  Relevance score: 0.00

  Ilya A. Demyanenko, Ekaterina N. Popova, Vlada V. Zakharova, Olga P. Ilyinskaya, Tamara V. Vasilieva, Valeria P. Romashchenko, Artem V. Fedorov, Vasily N. Manskikh, Maxim V. Skulachev, Roman A. Zinovkin, Olga Yu. Pletjushkina, Vladimir P. Skulachev, Boris V. Chernyak

  Keywords: wound healing, mitochondrial reactive oxygen species, mitochondria-targeted antioxidant

  Published in Aging on June 30, 2015

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• Research PaperVolume 1, Issue 4pp 389-401

  Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats

  Relevance score: 0.00

  Lidia A. Obukhova, Vladimir P. Skulachev, Natalia G. Kolosova

  Keywords: aging, thymus, progeric OXYS rats, mitochondrial-targeted antioxidant SkQ1

  Published in Aging on April 22, 2009

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• Research PaperVolume 15, Issue 16pp 8137-8154

  CEACAM1 as a molecular target in oral cancer

  Relevance score: 0.00

  Sai Ma, Zhonghua Wang, Chao Li, Zhenli Liu, Xuan Zhang, Liheng Li, Feng An, Xiaoli Qiao

  Keywords: CEACAM1, molecular target, oral cancer, bioinformatics

  Published in Aging on August 16, 2023

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• Research PaperVolume 15, Issue 7pp 2485-2502

  NR5A2 as a potential target for exercise to improve metabolic syndrome

  Relevance score: 0.00

  Lingxiu Meng, Fusheng Dong, Junguo Deng

  Keywords: metabolic syndrome, movement, NR5A2, potential targets, cardiovascular diseases

  Published in Aging on March 26, 2023

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• Research PaperVolume 14, Issue 10pp 4425-4444

  Transcriptional ITPR3 as potential targets and biomarkers for human pancreatic cancer

  Relevance score: 0.00

  Wangyang Zheng, Xue Bai, Yongxu Zhou, Liang Yu, Daolin Ji, Yuling Zheng, Nanfeng Meng, Hang Wang, Ziyue Huang, Wangming Chen, Judy Wai Ping Yam, Yi Xu, Yunfu Cui

  Keywords: pancreatic cancer, bioinformatics analysis, ITPRs, therapeutic targets, biomarker

  Published in Aging on May 17, 2022

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• Research PaperVolume 13, Issue 20pp 23702-23725

  Selected ideal natural ligand against TNBC by inhibiting CDC20, using bioinformatics and molecular biology

  Relevance score: 0.00

  Naimeng Liu, Xinhui Wang, Zhu Zhu, Duo Li, Xiaye Lv, Yichang Chen, Haoqun Xie, Zhen Guo, Dong Song

  Keywords: CDC20, drug development, virtual screening, TNBC, targeted therapy

  Published in Aging on October 22, 2021

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• Research PaperVolume 12, Issue 20pp 20457-20470

  Designing high affinity target-binding peptides to HLA-E: a key membrane antigen of multiple myeloma

  Relevance score: 0.00

  Ying Yang, Mingli Sun, Zhaojin Yu, Jinwei Liu, Wei Yan, Zhuogang Liu, Minjie Wei, Hongtao Wang

  Keywords: multiple myeloma, HLA-E, protein-protein interaction, key membrane antigen, high affinity target-binding peptides

  Published in Aging on October 28, 2020

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• Research PaperVolume 12, Issue 18pp 18238-18250

  The mitochondrial-targeted peptide SBT-20 ameliorates inflammation and oxidative stress in chronic renal failure

  Relevance score: 0.00

  Lina Sun, Haiping Xu, Yunfei Wang, Xiaoying Ma, Yan Xu, Fuyun Sun

  Keywords: chronic renal failure, mitochondrial-targeted peptide, SBT-20, oxidative stress, inflammation

  Published in Aging on September 25, 2020

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• Research PaperVolume 12, Issue 15pp 15784-15796

  Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19

  Relevance score: 0.00

  Rong Li, Ka Wu, Yu Li, Xiao Liang, William Ka Fai Tse, Lu Yang, Keng Po Lai

  Keywords: vitamin A, SARS-CoV-2, network pharmacology, target, mechanism, COVID-19

  Published in Aging on August 15, 2020

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• Research PaperVolume 10, Issue 2pp 229-240

  Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)

  Relevance score: 0.00

  Bela Ozsvari, Federica Sotgia, Michael P. Lisanti

  Keywords: tri-phenyl-phosphonium (TPP), cancer stem cells (CSCs), cancer therapy, mitochondrial targeting signal

  Published in Aging on February 19, 2018

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• EditorialVolume 7, Issue 10pp 746-747

  Prognostic marker and target in prostate cancer

  Relevance score: 0.00

  Giovanni Lavorgna, Francesco Montorsi, Andrea Salonia

  Keywords: ncRNA, biomarker, therapeutic target, apoptosis, prostate cancer

  Published in Aging on October 20, 2015

• Research PaperVolume 4, Issue 12pp 899-916

  Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging

  Relevance score: 0.00

  Olga V. Leontieva, Geraldine M. Paszkiewicz, Mikhail V. Blagosklonny

  Keywords: MTOR, mTOR Target of rapamycin, growth, aging

  Published in Aging on December 21, 2012

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