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Volume 4, Issue 12

December 2012pp 854—977

Editorials

Geropotency: Increased malignant potential of aging neural progenitors

Andrei M. Mikheev, Elizabeth A. Stoll, Rohan Ramakrishna, Svetlana A. Mikheeva, Philip J. Horner, Robert C. Rostomily

https://doi.org/10.18632/aging.100514pp 854—855

Heat shock response and ionstasis: axis against neurodegeneration

Nikos Kourtis, Vassiliki Nikoletopoulou, Nektarios Tavernarakis

https://doi.org/10.18632/aging.100517pp 856—858

Mitochondria, obesity and aging

Cecile Vernochet, C. Ronald Kahn

https://doi.org/10.18632/aging.100518pp 859—860

Reviews

Answering the ultimate question “What is the Proximal Cause of Aging?”

Mikhail V. Blagosklonny

https://doi.org/10.18632/aging.100525pp 861—877

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Embryonic stem cells and inducible pluripotent stem cells: two faces of the same coin?

Francesco Romeo, Francesco Costanzo, Massimiliano Agostini

https://doi.org/10.18632/aging.100513pp 878—886

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Recent discoveries in the cycling, growing and aging of the p53 field

James A. McCubrey, Zoya N. Demidenko

https://doi.org/10.18632/aging.100529pp 887—893

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Research Perspective

COVID-19

One-carbon metabolism: An aging-cancer crossroad for the gerosuppressant metformin

Javier A. Menendez, Jorge Joven

https://doi.org/10.18632/aging.100523pp 894—898

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Research Papers

Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging

Olga V. Leontieva, Geraldine M. Paszkiewicz, Mikhail V. Blagosklonny

https://doi.org/10.18632/aging.100528pp 899—916

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Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion

Sudha Mannava, Kalyana C. Moparthy, Linda J. Wheeler, Katerina I. Leonova, Joseph A. Wawrzyniak, Anna Bianchi-Smiraglia, Albert E. Berman, Sheryl Flanagan, Donna S. Shewach, Nathalie C. Zeitouni, Andrei V. Gudkov, Christopher K. Mathews, Mikhail A. Nikiforov

https://doi.org/10.18632/aging.100512pp 917—922

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P73 and age-related diseases: is there any link with Parkinson Disease?

Francesca Grespi, Gerry Melino

https://doi.org/10.18632/aging.100515pp 923—931

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IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

Sona Hubackova, Katerina Krejcikova, Jiri Bartek, Zdenek Hodny

https://doi.org/10.18632/aging.100520pp 932—951

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COVID-19

Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling

H. Dorota Halicka, Hong Zhao, Jiangwei Li, Yong-Syu Lee, Tze-Chen Hsieh, Joseph M. Wu, Zbigniew Darzynkiewicz

https://doi.org/10.18632/aging.100521pp 952—965

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Complete cardiac regeneration in a mouse model of myocardial infarction

Bernhard Johannes Haubner, Martyna Adamowicz-Brice, Sanjay Khadayate, Viktoria Tiefenthaler, Bernhard Metzler, Tim Aitman, Josef M. Penninger

https://doi.org/10.18632/aging.100526pp 966—977

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