Review Volume 4, Issue 12 pp 887—893
Recent discoveries in the cycling, growing and aging of the p53 field
- 1 Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, NC 27858, USA
- 2 Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Received: December 16, 2012 Accepted: December 22, 2012 Published: December 23, 2012
https://doi.org/10.18632/aging.100529How to Cite
Abstract
The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. What yet could be discovered about its role in cell death, growth arrest and apoptosis, as well as a mediator of the therapeutic effect of anticancer drugs. Still during recent few years even more amazing discoveries have been done. Here we review such topics as suppression of epigenetic silencing of a large number of non-coding RNAs, role of p53 in suppression of the senescence phenotype, inhibition of oncogenic metabolism, protection of normal cells from chemotherapy and even tumor suppression without apoptosis and cell cycle arrest.