Volume 11, Issue 12

June 30, 2019pp 3891—4299

About the Cover

The cover features Figure 2 "Modulation of autophagy by α-ketoglutarate precursors" from Zhang et al.

Editorials

Senescence utilises inflammatory caspases to drive SASP

Kimberley A. Wiggins, Murray CH. Clarke

https://doi.org/10.18632/aging.102031pp 3891—3892

PDF

Microbiota and the clock: sexual dimorphism matters!

Benjamin D. Weger, Frédéric Gachon

https://doi.org/10.18632/aging.102051pp 3893—3894

PDF

Phospholipid metabolism regulates AML growth and stemness

Mingjing Xu, Ayesh K. Seneviratne, Aaron D. Schimmer

https://doi.org/10.18632/aging.102055pp 3895—3897

PDF

Itaconate as an immune modulator

Anaísa V. Ferreira, Mihai G. Netea, Jorge Domínguez-Andrés

https://doi.org/10.18632/aging.102057pp 3898—3899

PDF

Research Papers

Mesenchymal stem cells rejuvenate cardiac muscle through regulating macrophage polarization

Busheng Zhang, Naishi Zhao, Jing Zhang, Yu Liu, Dan Zhu, Ye Kong

https://doi.org/10.18632/aging.102009pp 3900—3908

View Abstract PDF Full-Text

Alda-1 attenuates hyperoxia-induced mitochondrial dysfunction in lung vascular endothelial cells

Sahebgowda Sidramagowda Patil, Helena Hernández-Cuervo, Jutaro Fukumoto, Venkata Ramireddy Narala, Smita Saji, Monica Borra, Matthew Alleyn, Muling Lin, Ramani Soundararajan, Richard Lockey, Narasaiah Kolliputi, Lakshmi Galam

https://doi.org/10.18632/aging.102012pp 3909—3918

View Abstract PDF Full-Text

Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging

Man Zhang, Muhammed Burak Bener, Zongliang Jiang, Tianren Wang, Ecem Esencan, Richard Scott III, Tamas Horvath, Emre Seli

https://doi.org/10.18632/aging.102024pp 3919—3938

View Abstract PDF Full-Text

B7-CD28 gene family expression is associated with prognostic and immunological characteristics of diffuse large B-cell lymphoma

Gangjian Wang, Xiaorui Fu, Yu Chang, Xin Li, Xiaolong Wu, Ling Li, Lei Zhang, Zhenchang Sun, Xudong Zhang, Mingzhi Zhang

https://doi.org/10.18632/aging.102025pp 3939—3957

View Abstract PDF Full-Text

Prevalence and predisposing factors of depressive symptoms in patients with stable coronary artery disease: a cross-sectional single-center study

Yeshun Wu, Bin Zhu, Zijun Chen, Jiahao Duan, Ailin Luo, Ling Yang, Chun Yang

https://doi.org/10.18632/aging.102026pp 3958—3968

View Abstract PDF Full-Text

AGTR1 promotes lymph node metastasis in breast cancer by upregulating CXCR4/SDF-1α and inducing cell migration and invasion

Yuxi Ma, Zihan Xia, Chunmei Ye, Chong Lu, Sheng Zhou, Juan Pan, Cuiwei Liu, Jieying Zhang, Tao Liu, Ting Hu, Linka Xie, Gang Wu, Yanxia Zhao

https://doi.org/10.18632/aging.102032pp 3969—3992

View Abstract PDF Full-Text

Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals

Qin-Li Wan, Xiao Meng, Xiaodie Fu, Bohui Chen, Jing Yang, Hengwen Yang, Qinghua Zhou

https://doi.org/10.18632/aging.102033pp 3993—4010

View Abstract PDF Full-Text

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass

Xuehui Liu, Lei Wei, Qiongye Dong, Liyang Liu, Michael Q. Zhang, Zhen Xie, Xiaowo Wang

https://doi.org/10.18632/aging.102034pp 4011—4031

View Abstract PDF Full-Text

Long-time qingyan formula extract treatment exerts estrogenic activities on reproductive tissues without side effects in ovariectomized rats and via active ER to ERE-independent gene regulation

Hong-Xia Zheng, Yuan Zhao, Ying Xu, Zi-Jia Zhang, Jing-jing Zhu, Yuan-Fang Fan, Na Lin

https://doi.org/10.18632/aging.102035pp 4032—4049

View Abstract PDF Full-Text

TRPM7 channel inhibition exacerbates pulmonary arterial hypertension through MEK/ERK pathway

Junhui Xing, Mengyu Wang, Jin Hong, Yueqiao Gao, Yuzhou Liu, Heping Gu, Jianzeng Dong, Ling Li

https://doi.org/10.18632/aging.102036pp 4050—4065

View Abstract PDF Full-Text

Anti-aging interventions affect lifespan variability in sex, strain, diet and drug dependent fashion

Andrzej Bartke, Tracy R. Evans, C.J.M. Musters

https://doi.org/10.18632/aging.102037pp 4066—4074

View Abstract PDF Full-Text

TGF-β1 enhances FOXO3 expression in human synovial fibroblasts by inhibiting miR-92a through AMPK and p38 pathways

Shu-Jui Kuo, Shan-Chi Liu, Yuan-Li Huang, Chun-Hao Tsai, Yi-Chin Fong, Horng-Chaung Hsu, Chih-Hsin Tang

https://doi.org/10.18632/aging.102038pp 4075—4089

View Abstract PDF Full-Text

Cognitive compensatory mechanisms in normal aging: a study on verbal fluency and the contribution of other cognitive functions

Lissett Gonzalez-Burgos, Juan Andrés Hernández-Cabrera, Eric Westman, José Barroso, Daniel Ferreira

https://doi.org/10.18632/aging.102040pp 4090—4106

View Abstract PDF Full-Text

Grape seed proanthocyanidins ameliorate neuronal oxidative damage by inhibiting GSK-3β-dependent mitochondrial permeability transition pore opening in an experimental model of sporadic Alzheimer’s disease

Qinru Sun, Ning Jia, Xin Li, Jie Yang, Guomin Chen

https://doi.org/10.18632/aging.102041pp 4107—4124

View Abstract PDF Full-Text

Altered FoxO1 and PPARγ interaction in age-related ER stress-induced hepatic steatosis

Dae Hyun Kim, Sugyeong Ha, Yeon Ja Choi, H. Henry Dong, Byung Pal Yu, Hae Young Chung

https://doi.org/10.18632/aging.102042pp 4125—4144

View Abstract PDF Full-Text

Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice

Santosh Kumar, Shubhankar Suman, Albert J Fornace Jr., Kamal Datta

https://doi.org/10.18632/aging.102043pp 4145—4158

View Abstract PDF Full-Text

Proteomics-based identification of different training adaptations of aged skeletal muscle following long-term high-intensity interval and moderate-intensity continuous training in aged rats

Fang-Hui Li, Lei Sun, Da-Shuai Wu, Hao-En Gao, Zhu Min

https://doi.org/10.18632/aging.102044pp 4159—4182

View Abstract PDF Full-Text

Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK

Yuan Su, Tao Wang, Nan Wu, Diyan Li, Xiaolan Fan, Zhongxian Xu, Shailendra Kumar Mishra, Mingyao Yang

https://doi.org/10.18632/aging.102045pp 4183—4197

View Abstract PDF Full-Text

Integrated multi-omics analysis of genomics, epigenomics, and transcriptomics in ovarian carcinoma

Mingjun Zheng, Yuexin Hu, Rui Gou, Jing Wang, Xin Nie, Xiao Li, Qing Liu, Juanjuan Liu, Bei Lin

https://doi.org/10.18632/aging.102047pp 4198—4215

View Abstract PDF Full-Text

β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid

Meriem Bejaoui, Myra O. Villareal, Hiroko Isoda

https://doi.org/10.18632/aging.102048pp 4216—4237

View Abstract PDF Full-Text

Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels

Yunsung Lee, Sanaa Choufani, Rosanna Weksberg, Samantha L. Wilson, Victor Yuan, Amber Burt, Carmen Marsit, Ake T. Lu, Beate Ritz, Jon Bohlin, Håkon K. Gjessing, Jennifer R. Harris, Per Magnus, Alexandra M. Binder, Wendy P. Robinson, Astanand Jugessur, Steve Horvath

https://doi.org/10.18632/aging.102049pp 4238—4253

View Abstract PDF Full-Text

Sulfate assimilation regulates hydrogen sulfide production independent of lifespan and reactive oxygen species under methionine restriction condition in yeast

Kyung-Mi Choi, Sorah Kim, Seahyun Kim, Hae Min Lee, Alaattin Kaya, Bok-Hwan Chun, Yong Kwon Lee, Tae-Sik Park, Cheol-Koo Lee, Seong-il Eyun, Byung Cheon Lee

https://doi.org/10.18632/aging.102050pp 4254—4273

View Abstract PDF Full-Text

Review

The interplay between mineral metabolism, vascular calcification and inflammation in Chronic Kidney Disease (CKD): challenging old concepts with new facts

Carla Viegas, Nuna Araújo, Catarina Marreiros, Dina Simes

https://doi.org/10.18632/aging.102046pp 4274—4299

View Abstract PDF Full-Text