Volume 11, Issue 11

15 June, 2019
pp 3410—3890

About the Cover

The cover features Figure 2 "Modulation of autophagy by α-ketoglutarate precursors" from Baracco et al.

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Editorials

Counteracting sarcopenia: the role of IGF-1 isoforms

Antonio Musarò, Bianca Maria Scicchitano,

https://doi.org/10.18632/aging.102027 pp 3410—3411

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Heterogeneous cellular effects of α-ketoglutarate esters

Lorenzo Galluzzi,

https://doi.org/10.18632/aging.102028 pp 3412—3413

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Tissue microenvironment and benign prostatic hyperplasia

Xing Wei, Li Xin,

https://doi.org/10.18632/aging.102029 pp 3414—3415

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Age and MEN2 outcome

Frederic Castinetti,

https://doi.org/10.18632/aging.102030 pp 3416—3417

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Priority Research Paper

α-Ketoglutarate inhibits autophagy

Elisa Elena Baracco, Francesca Castoldi, Sylvère Durand, David P. Enot, Jelena Tadic, Katharina Kainz, Frank Madeo, Alexis Chery, Valentina Izzo, Maria Chiara Maiuri, Federico Pietrocola, Guido Kroemer,

https://doi.org/10.18632/aging.102001 pp 3418—3431

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Research Papers

Tumor-suppressive miR-3650 inhibits tumor metastasis by directly targeting NFASC in hepatocellular carcinoma

Jian Wu, Wen-Jin Huang, Hong-Li Xi, Ling-Yun Liu, Shu-Tong Wang, Wen-Zhe Fan, Bao-Gang Peng,

https://doi.org/10.18632/aging.101981 pp 3432—3444

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N-acetyl cysteine, inulin and the two as a combined therapy ameliorate cognitive decline in testosterone-deprived rats

Titikorn Chunchai, Puntarik Keawtep, Apiwan Arinno, Napatsorn Saiyasit, Dillon Prus, Nattayaporn Apaijai, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C. Chattipakorn,

https://doi.org/10.18632/aging.101989 pp 3445—3462

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CA-30, an oligosaccharide fraction derived from Liuwei Dihuang decoction, ameliorates cognitive deterioration via the intestinal microbiome in the senescence-accelerated mouse prone 8 strain

Jianhui Wang, Xi Lei, Zongjie Xie, Xiaorui Zhang, Xiaorui Cheng, Wenxia Zhou, Yongxiang Zhang,

https://doi.org/10.18632/aging.101990 pp 3463—3486

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Investigation of bidirectional longitudinal associations between advanced epigenetic age and peripheral biomarkers of inflammation and metabolic syndrome

Filomene G. Morrison, Mark W. Logue, Rachel Guetta, Hannah Maniates, Annjanette Stone, Steven A. Schichman, Regina E. McGlinchey, William P. Milberg, Mark W. Miller, Erika J. Wolf,

https://doi.org/10.18632/aging.101992 pp 3487—3504

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Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD⁺–Sirt1 signaling

Chenchen Pi, Yue Yang, Yanan Sun, Huan Wang, Hui Sun, Mao Ma, Lin Lin, Yingai Shi, Yan Li, Yulin Li, Xu He,

https://doi.org/10.18632/aging.101993 pp 3505—3522

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Biological markers and cardiac remodelling following the myocardial infarction

Olga Gruzdeva, Yulia Dyleva, Evgenya Uchasova, Olga Akbasheva, Victoria Karetnikova, Vasiliy Kashtalap, Aleksandr Shilov, Olga Polikutina, Yulia Slepynina, Olga Barbarash,

https://doi.org/10.18632/aging.101994 pp 3523—3535

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E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis

Guangwei Zeng, Chen Lian, Pei Yang, Mingming Zheng, He Ren, Haiyan Wang,

https://doi.org/10.18632/aging.101995 pp 3536—3550

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Age-related changes in the vasculature of the dermis of the upper lip vermilion

Takamasa Gomi, Toru Imamura,

https://doi.org/10.18632/aging.101996 pp 3551—3560

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Downregulation of circ_0132266 in chronic lymphocytic leukemia promoted cell viability through miR-337-3p/PML axis

Wei Wu, Zijuan Wu, Yi Xia, Shuchao Qin, Yue Li, Jiazhu Wu, Jinhua Liang, Li Wang, Huayuan Zhu, Lei Fan, Jianxin Fu, Wei Xu, Hui Jin, Jianyong Li,

https://doi.org/10.18632/aging.101997 pp 3561—3573

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TGF-β mediates aortic smooth muscle cell senescence in Marfan syndrome

Wei You, Yimei Hong, Haiwei He, Xiaoran Huang, Wuyuan Tao, Xiaoting Liang, Yuelin Zhang, Xin Li,

https://doi.org/10.18632/aging.101998 pp 3574—3584

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Blocking lncRNA H19-miR-19a-Id2 axis attenuates hypoxia/ischemia induced neuronal injury

Zhipeng Xiao, Yongming Qiu, Yingying Lin, Rogelio Medina, Sophie Zhuang, Jared S. Rosenblum, Jing Cui, Zezhi Li, Xiaohua Zhang, Liemei Guo,

https://doi.org/10.18632/aging.101999 pp 3585—3600

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Rh type C-glycoprotein functions as a novel tumor suppressor gene by inhibiting tumorigenicity and metastasis in head and neck squamous cell carcinoma

Wenguang Xu, Huihui Zou, Zheng Wei, Chuanhui Song, Chuanchao Tang, Xiteng Yin, Yufeng Wang, Shengwei Han, Yu Cai, Wei Han,

https://doi.org/10.18632/aging.102000 pp 3601—3623

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Proteasome-dependent degradation of intracellular carbamylated proteins

Aurore Desmons, Anaïs Okwieka, Manon Doué, Laëtitia Gorisse, Vincent Vuiblet, Christine Pietrement, Philippe Gillery, Stéphane Jaisson,

https://doi.org/10.18632/aging.102002 pp 3624—3638

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MORC2 promotes cell growth and metastasis in human cholangiocarcinoma and is negatively regulated by miR-186-5p

Guanqun Liao, Xiaopeng Liu, Dehai Wu, Fangting Duan, Xueyi Xie, Shunqian Wen, Yiqun Li, Shengping Li,

https://doi.org/10.18632/aging.102003 pp 3639—3649

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Real-world effectiveness of medications on survival in patients with COPD-heart failure overlap

Vincent Yi-Fong Su, Yao-Hsu Yang, Diahn-Warng Perng, Ying-Huang Tsai, Kun-Ta Chou, Kang-Cheng Su, Wei-Juin Su, Pau-Chung Chen, Kuang-Yao Yang,

https://doi.org/10.18632/aging.102004 pp 3650—3667

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Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling

Hongyi Wang, Bingyu Guo, Shixiu Lin, Peng Chang, Kai Tao,

https://doi.org/10.18632/aging.102006 pp 3668—3678

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Evaluation of the diagnostic ability of laminin gene family for pancreatic ductal adenocarcinoma

Chengkun Yang, Zhengqian Liu, Xianmin Zeng, Qiongyuan Wu, Xiwen Liao, Xiangkun Wang, Chuangye Han, Tingdong Yu, Guangzhi Zhu, Wei Qin, Tao Peng,

https://doi.org/10.18632/aging.102007 pp 3679—3703

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Integrating genome-wide association study with regulatory SNP annotation information identified candidate genes and pathways for schizophrenia

Xiao Liang, Sen Wang, Li Liu, Yanan Du, Bolun Cheng, Yan Wen, Yan Zhao, Miao Ding, Shiqiang Cheng, Mei Ma, Lu Zhang, Xin Qi, Ping Li, Xiong Guo, Feng Zhang,

https://doi.org/10.18632/aging.102008 pp 3704—3715

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Long non-coding RNA MEG3 promotes fibrosis and inflammatory response in diabetic nephropathy via miR-181a/Egr-1/TLR4 axis

Fangfang Zha, Xiaolu Qu, Bo Tang, Ji Li, Yakun Wang, PengXi Zheng, Tingting Ji, Chun Zhu, Shoujun Bai,

https://doi.org/10.18632/aging.102011 pp 3716—3730

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Nectandrin B-mediated activation of the AMPK pathway prevents cellular senescence in human diploid fibroblasts by reducing intracellular ROS levels

Hyun-Jin Jang, Kyeong Eun Yang, Won Keun Oh, Song-I Lee, In-Hu Hwang, Kyung-Tae Ban, Hwa-Seung Yoo, Jong-Soon Choi, Eui-Ju Yeo, Ik-Soon Jang,

https://doi.org/10.18632/aging.102013 pp 3731—3749

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Mitochondrial and autophagic alterations in skin fibroblasts from Parkinson disease patients with Parkin mutations

Ingrid González-Casacuberta, Diana-Luz Juárez-Flores, Mario Ezquerra, Raquel Fucho, Marc Catalán-García, Mariona Guitart-Mampel, Ester Tobías, Carmen García-Ruiz, José Carlos Fernández-Checa, Eduard Tolosa, María-José Martí, Josep Maria Grau, Rubén Fernández-Santiago, Francesc Cardellach, Constanza Morén, Glòria Garrabou,

https://doi.org/10.18632/aging.102014 pp 3750—3767

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Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway

Benrong Liu, Lin Wang, Wenyi Jiang, Yujuan Xiong, Lihua Pang, Yun Zhong, Chongyu Zhang, Wenchao Ou, Chaowei Tian, Xiaohui Chen, Shi-Ming Liu,

https://doi.org/10.18632/aging.102015 pp 3768—3784

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Metformin prevents murine ovarian aging

Xian Qin, Dingfu Du, Qian Chen, Meng Wu, Tong Wu, Jingyi Wen, Yan Jin, Jinjin Zhang, Shixuan Wang,

https://doi.org/10.18632/aging.102016 pp 3785—3794

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Kainic acid Induces production and aggregation of amyloid β-protein and memory deficits by activating inflammasomes in NLRP3- and NF-κB-stimulated pathways

Yang Ruan, Xiang Qiu, Yu-Dan Lv, Dong Dong, Xiu-Juan Wu, Jie Zhu, Xiang-Yu Zheng,

https://doi.org/10.18632/aging.102017 pp 3795—3810

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Long non-coding RNA AGAP2-AS1 exerts oncogenic properties in glioblastoma by epigenetically silencing TFPI2 through EZH2 and LSD1

Wenzheng Luo, Xueyuan Li, Zhenyu Song, Xuqiang Zhu, Shanshan Zhao,

https://doi.org/10.18632/aging.102018 pp 3811—3823

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Elevated homocysteine as an independent risk for intracranial atherosclerotic stenosis

Ying Liu, Jing-Hui Song, Xiao-He Hou, Ya-Hui Ma, Xue-Ning Shen, Wei Xu, Fu-Rong Sun, Qiang Dong, Jin-Tai Yu, Lan Tan, Song Chi,

https://doi.org/10.18632/aging.102019 pp 3824—3831

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Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice

Laurie Caland, Pauline Labbé, Maya Mamarbachi, Louis Villeneuve, Gerardo Ferbeyre, Pierre-Emmanuel Noly, Michel Carrier, Nathalie Thorin-Trescases, Éric Thorin,

https://doi.org/10.18632/aging.102020 pp 3832—3850

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Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape

Monica Serra, Fabio Marongiu, Maria Giuseppina Pisu, Mariangela Serra, Ezio Laconi,

https://doi.org/10.18632/aging.102021 pp 3851—3863

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Immune senescence and immune activation in elderly colorectal cancer patients

Silvia Giunco, Maria Raffaella Petrara, Francesca Bergamo, Paola Del Bianco, Marisa Zanchetta, Francesco Carmona, Vittorina Zagonel, Anita De Rossi, Sara Lonardi,

https://doi.org/10.18632/aging.102022 pp 3864—3875

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Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation

Junhua Li, Rafael Romero-Garcia, John Suckling, Lei Feng,

https://doi.org/10.18632/aging.102023 pp 3876—3890

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