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Research Paper|Volume 11, Issue 11|pp 3824—3831

Elevated homocysteine as an independent risk for intracranial atherosclerotic stenosis

Ying Liu1, Jing-Hui Song1, Xiao-He Hou2, Ya-Hui Ma2, Xue-Ning Shen3, Wei Xu2, Fu-Rong Sun2, Qiang Dong3, Jin-Tai Yu3, Lan Tan2, Song Chi1
  • 1Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China
  • 2Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China
  • 3Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
* Equal contribution
Received: April 22, 2019Accepted: June 3, 2019Published: June 12, 2019
https://doi.org/10.18632/aging.102019

Copyright: Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

To investigate the association of homocysteine concentration with intracranial atherosclerotic stenosis (ICAS), we assessed 933 acute ischemic stroke patients (346 with ICAS, 587 without ICAS) and 798 non-stroke controls (175 with ICAS, 623 without ICAS) with magnetic resonance angiography (MRA). Homocysteine concentration was found to be significantly higher in participants with ICAS than those without ICAS. In logistic regression analyses, homocysteine concentration was significantly associated with ICAS both in patients (OR: 1.04; 95% CI: 1.01–1.08; P=0.008) and controls (OR: 1.10; 95% CI: 1.06–1.15; P<0.001) for 1 μmol/L increment in homocysteine. Compared with the lowest quartile, the second (OR:1.53; 95% CI: 1.01-2.33), third (OR:1.71; 95% CI: 1.14 -2.60) and fourth (OR:2.48; 95%CI: 1.63-3.81) quartiles were independent predictors of ICAS in patients (P for trend<0.001); the third (OR:1.99; 95% CI: 1.18-3.40) and fourth (OR:2.36; 95%CI: 1.38-4.10) quartiles were independent predictors of ICAS in controls (P for trend<0.001). Hence, elevated homocysteine might be an independent risk for ICAS.