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• Research PaperVolume 13, Issue 23pp 25377-25392

  Tartary buckwheat flavonoids relieve the tendency of mammary fibrosis induced by HFD during pregnancy and lactation

  Relevance score: 0.00

  Xingchi Kan, Juxiong Liu, Xiangyu Cai, Yaping Huang, Ping Xu, Shoupeng Fu, Wenjin Guo, Guiqiu Hu

  Keywords: high-fat diet, inflammatory microenvironment, AKT/NF-κB, blood-milk barrier, fibrosis

  Published in Aging on December 10, 2021

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• Research PaperVolume 14, Issue 16pp 6626-6641

  Oxypeucedanin relieves LPS-induced acute lung injury by inhibiting the inflammation and maintaining the integrity of the lung air-blood barrier

  Relevance score: 0.00

  Li Du, Jinrong Zhang, Xiyue Zhang, Chunyan Li, Qi Wang, Guangping Meng, Xingchi Kan, Jie Zhang, Yuxi Jia

  Keywords: acute lung injury, lipopolysaccharide, PI3K/AKT/NF-κB, MAPKs, molecular docking simulation

  Published in Aging on August 18, 2022

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• Research PaperVolume 13, Issue 15pp 19460-19474

  Pedunculoside protects against LPS-induced mastitis in mice by inhibiting inflammation and maintaining the integrity of blood-milk barrier

  Relevance score: 0.00

  Xingchi Kan, Guiqiu Hu, Bingxu Huang, Wenjin Guo, Yaping Huang, Yingsheng Chen, Ping Xu, Xiangyu Cai, Shoupeng Fu, Juxiong Liu

  Keywords: mastitis, LPS, AKT/NF-κB, MAPK, blood-milk barrier

  Published in Aging on August 12, 2021

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• Research PaperVolume 13, Issue 23pp 25408-25425

  lncRNA CASC7 regulates pathological progression of ox-LDL-stimulated atherosclerotic cell models via sponging miR-21 and regulating PI3K/Akt and TLR4/NF-κB signaling pathways

  Relevance score: 0.00

  Xueliang Pei, Yongjin Wen, Facai Cui, Zhiyuan Yang, Zhouliang Xie

  Keywords: atherosclerosis, CASC7, miR-21, PI3K/Akt, TLR4/NF-κB, proliferation

  Published in Aging on December 9, 2021

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• Research PaperVolume 16, Issue 8pp 6937-6953

  High-dose Vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF-κB and PI3K/AKT/mTOR signaling pathways in rats

  Relevance score: 0.00

  Ya-Nan Cui, Na Tian, Yan-Hai Luo, Ji-Jun Zhao, Cheng-Fei Bi, Yi Gou, Jia Liu, Ke Feng, Jun-Fei Zhang

  Keywords: High-dose Vitamin C, sepsis-induced myocardial injury, apoptosis, autophagy, inflammatory, MAPK, NF-κB and PI3K/AKT/mTOR signaling pathways

  Published in Aging on April 19, 2024

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• Research PaperVolume 7, Issue 12pp 1094-1108

  Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

  Relevance score: 0.00

  Ana Maria Marques Orellana, Andrea Rodrigues Vasconcelos, Jacqueline Alves Leite, Larissa de Sá Lima, Diana Zukas Andreotti, Carolina Demarchi Munhoz, Elisa Mitiko Kawamoto, Cristoforo Scavone

  Keywords: NF-κB, AKT, β-CATENIN, GCs, GSK-3β

  Published in Aging on December 6, 2015

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• Research PaperVolume 15, Issue 4pp 1210-1227

  Inhibition of apoptosis through AKT-mTOR pathway in ovarian cancer and renal cancer

  Relevance score: 0.00

  Hongrun Chen, Lianfeng Zhang, Meini Zuo, Xiaowen Lou, Bin Liu, Taozhu Fu

  Keywords: Akt-mTOR pathway, renal cancer, ovarian cancer, bioinformatics, verification, biomarker

  Published in Aging on February 27, 2023

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• Research PaperVolume 12, Issue 8pp 6928-6946

  AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupting tissue remodeling

  Relevance score: 0.00

  Song Gu, Hanhao Dai, Xilian Zhao, Chang Gui, Jianchao Gui

  Keywords: cutaneous wound healing, M2 macrophage, tissue remodeling, AKT3, AKT signaling

  Published in Aging on April 14, 2020

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• Research PaperVolume 11, Issue 20pp 8760-8776

  Adipose tissue-derived omentin-1 attenuates arterial calcification via AMPK/Akt signaling pathway

  Relevance score: 0.00

  Feng Xu, Fu-Xing-Zi Li, Xiao Lin, Jia-Yu Zhong, Feng Wu, Su-Kang Shan, Chang-Ming Tan, Ling-Qing Yuan, Xiao-Bo Liao

  Keywords: Akt, AMP-activated protein kinase, omentin-1, smooth muscle differentiation, arterial calcification

  Published in Aging on October 25, 2019

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• Research Paper

  Chronic stress promotes premature ovarian failure in mice by inhibiting ovarian granulosa cell autophagy through PI3K-AKTmTOR pathway

  Relevance score: 0.00

  Zhibin Zhao, Xuefei Yuan, Baohua Zhao, Kai He

  Keywords: PI3K-AKT-mTOR pathway, premature ovarian failure (POF), ovarian granulosa cells (OGCs), chronic stress

  Published in Aging on October 8, 2024

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• Research PaperVolume 15, Issue 9pp 3381-3393

  PI3K-Akt signaling pathway based on network pharmacology for the anti-Alzheimer’s disease effect of licorice stem flavonoids

  Relevance score: 0.00

  Hongyan Pei, Lei He, Meiling Shi, Xiangjuan Guo, Weijia Chen, Jianming Li, Zhongmei He, Rui Du

  Keywords: network pharmacology, Alzheimer’s disease, licorice stem flavonoids, PI3K-Akt signalling pathway

  Published in Aging on February 22, 2023

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• Research PaperVolume 14, Issue 5pp 2418-2431

  miRNA-29a inhibits atherosclerotic plaque formation by mediating macrophage autophagy via PI3K/AKT/mTOR pathway

  Relevance score: 0.00

  Weihua Shao, Suxing Wang, Xiaoxi Wang, Lixia Yao, Xiaoye Yuan, Dai Huang, Bonan Lv, Yuquan Ye, Hongyuan Xue

  Keywords: PI3K/AKT/mTOR, miR-29a, macrophage, plaque, atherosclerotic, atherosclerosis

  Published in Aging on March 14, 2022

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• Research PaperVolume 12, Issue 10pp 9489-9499

  PI3K-Akt-mTOR inhibition by GNE-477 inhibits renal cell carcinoma cell growth in vitro and in vivo

  Relevance score: 0.00

  Xueting Ye, Jian-Wei Ruan, Hang Huang, Wei-Ping Huang, Yan Zhang, Fangyi Zhang

  Keywords: renal cell carcinoma, PI3K-Akt-mTOR, GNE-477, molecularly-targeted therapies

  Published in Aging on May 18, 2020

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• Research PaperVolume 12, Issue 3pp 2030-2048

  High expression of SMYD3 indicates poor survival outcome and promotes tumour progression through an IGF-1R/AKT/E2F-1 positive feedback loop in bladder cancer

  Relevance score: 0.00

  Guoliang Wang, Yi Huang, Feilong Yang, Xiaojun Tian, Kun Wang, Li Liu, Yidong Fan, Xiaofeng Li, Luchao Li, Benkang Shi, Yichang Hao, Chuanyou Xia, Qingsheng Nie, Yue Xin, Zhenfeng Shi, Lulin Ma, Dawei Xu, Cheng Liu

  Keywords: SMYD3, bladder cancer, AKT, IGF1R, E2F-1

  Published in Aging on February 1, 2020

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• Research PaperVolume 15, Issue 23pp 14172-14191

  Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer’s disease-like neuropathology and cognitive deficits

  Relevance score: 0.00

  Ling Lei, Yong Luo, Dongkun Kang, Fumin Yang, Dongli Meng, Jian-Zhi Wang, Rong Liu, Xiaochuan Wang, Hong-Lian Li

  Keywords: Gypenoside IX, anti-apoptotic, Aβ, tau, Akt/GSK-3β

  Published in Aging on December 12, 2023

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• Research PaperVolume 13, Issue 13pp 17370-17379

  Baicalein ameliorates osteoporosis via AKT/FOXO1 signaling

  Relevance score: 0.00

  Pan Cai, Yan Lu, Zhifeng Yin, Xiuhui Wang, Xiaoxiao Zhou, Zhuokai Li

  Keywords: baicalein, osteoporosis, KEGG, AKT

  Published in Aging on July 1, 2021

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• Research PaperVolume 12, Issue 19pp 19147-19158

  BRD4 inhibition sensitizes renal cell carcinoma cells to the PI3K/mTOR dual inhibitor VS-5584

  Relevance score: 0.00

  Ming Xu, Lijun Xu, Yin Wang, Guangcheng Dai, Boxin Xue, Yuan-yuan Liu, Jianbing Zhu, Jin Zhu

  Keywords: renal cell carcinoma, PI3K/AKT/mTOR, VS-5584, BRD4, chemosensitization

  Published in Aging on October 13, 2020

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• Research PaperVolume 11, Issue 23pp 11369-11381

  Posttranscriptional regulation of AKT by circular RNA angiomotin- like 1 mediates chemoresistance against paclitaxel in breast cancer cells

  Relevance score: 0.00

  Jian Ma, Ling Fang, Qi Yang, Steven Hibberd, William W. Du, Nan Wu, Burton B. Yang

  Keywords: circular RNA, circAMOTL1, chemoresistance, PAX, AKT

  Published in Aging on December 9, 2019

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• CorrectionVolume 17, Issue 8pp 2240-2240

  Correction for: Posttranscriptional regulation of AKT by circular RNA angiomotin-like 1 mediates chemoresistance against paclitaxel in breast cancer cells

  Relevance score: 0.00

  Jian Ma, Ling Fang, Qi Yang, Steven Hibberd, William W. Du, Nan Wu, Burton B. Yang

  Keywords: circular RNA, circAMOTL1, chemoresistance, PAX, AKT

  Published in Aging on August 31, 2025

• Research PaperVolume 15, Issue 20pp 11162-11183

  Machine learning developed a PI3K/Akt pathway-related signature for predicting prognosis and drug sensitivity in ovarian cancer

  Relevance score: 0.00

  Xiaofang Han, Liu Yang, Hui Tian, Yuanyuan Ji

  Keywords: immunotherapy, prognostic signature, ovarian cancer, machine learning, PI3K/Akt pathway

  Published in Aging on October 17, 2023

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