Volume 16, Issue 5

March 15, 2024pp 4075—4947

About the Cover

The cover features Figure 1 "Differential gene expression analysis overall and by sex" from Zarrella and Tsurumi

Research Papers

Genome-wide transcriptome profiling and development of age prediction models in the human brain

Joseph A. Zarrella, Amy Tsurumi

https://doi.org/10.18632/aging.205609pp 4075—4094

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FoxO6-mediated ApoC3 upregulation promotes hepatic steatosis and hyperlipidemia in aged rats fed a high-fat diet

Dae Hyun Kim, Seulah Lee, Sang Gyun Noh, Jaewon Lee, Hae Young Chung

https://doi.org/10.18632/aging.205610pp 4095—4115

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PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation

Chitra Palanivel, Lepakshe S. V. Madduri, Ashley L. Hein, Christopher B. Jenkins, Brendan T. Graff, Alison L. Camero, Sumin Zhou, Charles A. Enke, Michel M. Ouellette, Ying Yan

https://doi.org/10.18632/aging.205619pp 4116—4137

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Azilsartan improves urinary albumin excretion in hypertension mice

Jun Cao, Dandan Zhang, Wenfeng Li, Wenjin Yuan, Gang Luo, Shaofeng Xie

https://doi.org/10.18632/aging.205271pp 4138—4148

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Complementary biomarkers of computed tomography for diagnostic grading of gastric cancer: DSCC1 and GINS1

Yufeng Zhu, Shiyang Hou, Chunbo Kang

https://doi.org/10.18632/aging.205491pp 4149—4168

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RAB22A as a predictor of exosome secretion in the progression and relapse of multiple myeloma

Bingjie Fan, Li Wang, Jishi Wang

https://doi.org/10.18632/aging.205565pp 4169—4190

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Calycosin (CA) inhibits proliferation, migration and invasion by suppression of CXCL10 signaling pathway in glioma

Xiaoyu Zheng, Danmin Chen, Menghui Li, Jianchen Liao, Liqun He, Lu Chen, Rong Xu, Maoying Zhang

https://doi.org/10.18632/aging.205572pp 4191—4203

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The crucial role of age and site in incidence and prognosis of female neuroendocrine neoplasms in the United States: a population-based study from 2000 to 2018

Guixiu Xiao, Zihan Xu, Yong Zhang, Shuang Dai, Ganlu Ouyang, Yan Huang, Yanyang Liu, Dan Cao, Feng Luo

https://doi.org/10.18632/aging.205573pp 4204—4223

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The effect of STAT1, miR-99b, and MAP2K1 in alcoholic liver disease (ALD) mouse model and hepatocyte

Hongbo Du, Hao Yu, Meiyue Zhou, Quan Hui, Yixin Hou, Yuyong Jiang

https://doi.org/10.18632/aging.205579pp 4224—4235

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AST-120 improved uremic pruritus by lowering indoxyl sulfate and inflammatory cytokines in hemodialysis patients

Chia-Chao Wu, Ya-Chung Tian, Chien-Lin Lu, Ming-Ju Wu, Paik-Seong Lim, Yi-Wen Chiu, Ko-Lin Kuo, Shou-Hsuan Liu, Yu-Ching Chou, Chien-An Sun, Yi-Chou Hou, Kuo-Cheng Lu

https://doi.org/10.18632/aging.205580pp 4236—4249

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Lei’s formula attenuates osteoarthritis mediated by suppression of chondrocyte senescence via the mTOR axis: in vitro and in vivo experiments

Xing Zhou, Wen-Kai Li, Chen Zhuang, Xing-Chen Zhou, Xue-Fei Zhao, Yu Pan, Wen-Xuan Guo, Yi-Wen Yang, Cen-Zhuo Sheng, Zhe-Fei Xie, Jin-Sheng Yu, Yi-Xuan Chen, Li-Kang Wang, Tian-You Ma, Kang-Xiang Zhu, Ke-Meng Xiang, Ru-Jie Zhuang

https://doi.org/10.18632/aging.205582pp 4250—4269

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Genetically predicted telomere length and the risk of 11 hematological diseases: a Mendelian randomization study

Yimin Wang, Qi Liu, Shibing Liang, Minghao Yao, Huimin Zheng, Dongqing Hu, Yifei Wang

https://doi.org/10.18632/aging.205583pp 4270—4281

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GABA in the anterior cingulate cortex mediates the association of white matter hyperintensities with executive function: a magnetic resonance spectroscopy study

Xiaona Fu, Peng Sun, Xinli Zhang, Dongyong Zhu, Qian Qin, Jue Lu, Jing Wang

https://doi.org/10.18632/aging.205585pp 4282—4298

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The tsRNAs (tRFdb-3013a/b) serve as novel biomarkers for colon adenocarcinomas

Lihong Tan, Xiaoling Wu, Zhurong Tang, Huan Chen, Weiguo Cao, Chunjie Wen, Guojun Zou, Hecun Zou

https://doi.org/10.18632/aging.205590pp 4299—4326

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4-Hydroxyphenylpyruvate Dioxygenase-Like predicts the prognosis and the immunotherapy response of cancers: a pan-cancer analysis

Huimin Li, Junzhi Liu, Shurui Wang, Yue Xu, Qiang Tang, Guoguang Ying

https://doi.org/10.18632/aging.205591pp 4327—4347

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Prenatal diesel exhaust exposure alters hippocampal synaptic plasticity in offspring

Shali Yu, Ziyang Zhang, Ziyu Qin, Meijun Liu, Xiaoye Zhao, Yulan Cheng, Peng Xue, Xiaoke Wang, Lin Chen, Qiyun Wu, Linling Ju, Juan Tang

https://doi.org/10.18632/aging.205592pp 4348—4362

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Probucol protects against brain damage caused by intra-neural pyroptosis in rats with vascular dementia through inhibition of the Syk/Ros pathway

Jingyi Zhu, Jing Du, Wenhui Kou, Chenling Liu, Jianchun Fan, Ziyan Zhu, Lexiu Deng, Lingling Guan, Yuandi Wang, Aimei Yu

https://doi.org/10.18632/aging.205593pp 4363—4377

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The prognosis, chemotherapy and immunotherapy efficacy of the SUMOylation pathway signature and the role of UBA2 in lung adenocarcinoma

Liying Yu, Na Lin, Yan Ye, Haohan Zhuang, Shumei Zou, Yingfang Song, Xiaoli Chen, Qingshui Wang

https://doi.org/10.18632/aging.205594pp 4378—4395

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A pair of primary colorectal cancer-derived and corresponding synchronous liver metastasis-derived organoid cell lines

Fangling Cheng, Pengcheng Li, Sanpeng Xu, Chao Zhang, Huifang Liang, Zeyang Ding

https://doi.org/10.18632/aging.205595pp 4396—4422

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SLC20A1 is a prospective prognostic and therapy response predictive biomarker in head and neck squamous cell carcinoma

Xiajing Qian, Ming Jin, Yanping Bei, Chongchang Zhou, Shuai Fang, Kaitai Liu

https://doi.org/10.18632/aging.205597pp 4423—4444

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Comprehensive characterization of Fidgetin on tumor immune microenvironment evaluation and immunotherapy in human hepatocellular carcinoma

Longju Qi, Shiyuan Chen, Zehua Liao, Mengjie Fan, Jiayi Zhang, Yuan Gao, Jiabao Shen, Yuyu Sun, Qinghua Wang

https://doi.org/10.18632/aging.205598pp 4445—4468

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Single-cell RNA combined with bulk RNA analysis to explore oxidative stress and energy metabolism factors and found a new prostate cancer oncogene MXRA8

Miao Miao, Yan Song, Mingyue Jin, Yang Du, Peng Xin, Yuanjun Jiang, Hao Zhang

https://doi.org/10.18632/aging.205599pp 4469—4502

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Exploration of the utility of different doses of Qingfei Dayuan granules: a multicenter, randomized, double-blind, placebo-controlled trial

Xiaoyun Zhu, Weinan Li, Yi Yang, Hengfei Li, Min Yang, Jilong Zhang, Xucheng Li, Guangjun Yan, Xiongfei Wu, Weijun Zhao, Mengdi Cui, Xi Yang, Xinyu Hu, Juan Huang, Yuanming Ba

https://doi.org/10.18632/aging.205601pp 4503—4517

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Tumor-infiltrating macrophage associated lncRNA signature in cutaneous melanoma: implications for diagnosis, prognosis, and immunotherapy

Qi Wan, Yuhua Deng, Ran Wei, Ke Ma, Jing Tang, Ying-Ping Deng

https://doi.org/10.18632/aging.205606pp 4518—4540

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Ningxin-Tongyu-Zishen formula alleviates the senescence of granulosa cells on D-galactose-induced premature ovarian insufficiency mice

Jia-Wen Ma, Zeng-Yan Xiong, Xing-Chu Cai, Xiang Li, Shi-Yan Ren, Shuai-Qi An, Zai-Yang Zhang, Yi-Zhou Zhang

https://doi.org/10.18632/aging.205607pp 4541—4562

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Machine learning-based endoplasmic reticulum-related diagnostic biomarker and immune microenvironment landscape for osteoarthritis

Tingting Liu, Xiaomao Li, Mu Pang, Lifen Wang, Ye Li, Xizhe Sun

https://doi.org/10.18632/aging.205611pp 4563—4578

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A novel classification predicts prognosis and drug sensitivity in osteosarcoma based on alterations in gene sets

Shuxi Ye, Xiaopeng Wang, Rongchun Chen

https://doi.org/10.18632/aging.205614pp 4579—4590

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GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription

Juyi Li, Yingqun Ni, Yuanyuan Zhang, Huaizhen Liu

https://doi.org/10.18632/aging.205616pp 4591—4608

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Myogenic exosome miR-140-5p modulates skeletal muscle regeneration and injury repair by regulating muscle satellite cells

Xiaorui Cao, Linli Xue, Xiuju Yu, Yi Yan, Jiayin Lu, Xiaomao Luo, Haidong Wang, Juan Wang

https://doi.org/10.18632/aging.205617pp 4609—4630

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miR-26a-5p inhibits the proliferation of psoriasis-like keratinocytes in vitro and in vivo by dual interference with the CDC6/CCNE1 axis

Jianing Li, Daxin Pang, Lin Zhou, Hongsheng Ouyang, Yaping Tian, Hao Yu

https://doi.org/10.18632/aging.205618pp 4631—4653

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Explainable machine learning in outcome prediction of high-grade aneurysmal subarachnoid hemorrhage

Lei Shu, Hua Yan, Yanze Wu, Tengfeng Yan, Li Yang, Si Zhang, Zhihao Chen, Qiuye Liao, Lu Yang, Bing Xiao, Minhua Ye, Shigang Lv, Miaojing Wu, Xingen Zhu, Ping Hu

https://doi.org/10.18632/aging.205621pp 4654—4669

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Echinatin mitigates sevoflurane-induced neurotoxicity through regulation of ferroptosis and iron homeostasis

Yanqiu You, Xudong Zhou, Qiuqin Tang, Tianshou Zhao, Juan Wang, Hanqin Huang, Jibing Chen, Zhongquan Qi, Fujun Li

https://doi.org/10.18632/aging.205622pp 4670—4683

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Genetically determined telomere length as a risk factor for hematological malignancies: evidence from Mendelian randomization analysis

Tian Fang, Zhihao Zhang, Kexing Ren, Liqun Zou

https://doi.org/10.18632/aging.205625pp 4684—4698

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SUMF1 overexpression promotes tumorous cell growth and migration and is correlated with the immune status of patients with glioma

Ping Zhang, Zhao Liu, Yu-Yu Wang, Hui-Jiu Luo, Chao-Zhi Yang, Hao Shen, Hai-Tao Wu, Ju-Hang Li, Hong-Xin Zhao, Qi-Shan Ran

https://doi.org/10.18632/aging.205626pp 4699—4722

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A Mendelian randomization analysis identifies causal association between sarcopenia and gastroesophageal reflux disease

Renwang Hu, Can Liu, Dan Li

https://doi.org/10.18632/aging.205627pp 4723—4735

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Investigating the mechanisms of drug resistance and prognosis in ovarian cancer using single-cell RNA sequencing and bulk RNA sequencing

Pengfei Liu, Jinbao Liu, Jinxing Liu, Xiao Yu

https://doi.org/10.18632/aging.205628pp 4736—4758

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Network pharmacology and transcriptomic profiling elucidate the therapeutic effects of Ranunculus ternatus Thunb on liver fibrosis via MK3-NF-κB inhibition

Lu Han, Guoyuan Lin, Jianchao Li, Qingxiu Zhang, Tao Ran, Tao Huang, Ruihan Hu, Shu Feng, Gaoliang Zou, Shaojie Chen, Xueke Zhao

https://doi.org/10.18632/aging.205629pp 4759—4777

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The low expression of miR-155 promotes the expression of SHP2 by inhibiting the activation of the ERK1/2 pathway and improves cell pyroptosis induced by I/R in mice

Mengru Liu, Dongliang Fu, Tong Gao, Hong Jiang, Peng Yang, Xianlun Li

https://doi.org/10.18632/aging.205631pp 4778—4788

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SORBS1 inhibits epithelial to mesenchymal transition (EMT) of breast cancer cells by regulating PI3K/AKT signaling and macrophage phenotypic polarization

Kai Feng, Ya Di, Meng Han, Weitao Yan, Yimin Wang

https://doi.org/10.18632/aging.205632pp 4789—4810

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FHND004 inhibits malignant proliferation of multiple myeloma by targeting PDZ-binding kinase in MAPK pathway

Hongjie Wu, Jinjun Qian, Lianxin Zhou, Tingting Hu, Yuanjiao Zhang, Chen Wang, Ye Yang, Chunyan Gu

https://doi.org/10.18632/aging.205634pp 4811—4831

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Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation

Chien-Yi Ho, Chih-Hsin Tang, Trung-Loc Ho, Wen-Ling Wang, Chun-Hsu Yao

https://doi.org/10.18632/aging.205635pp 4832—4840

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HOXC9 characterizes a suppressive tumor immune microenvironment and integration with multiple immune biomarkers predicts response to PD-1 blockade plus chemotherapy in lung adenocarcinoma

Liang Liu, Zhenshan Zhang, Chenxue Jiang, Yaoyao Zhu, Ruiqin Han, Leilei Wu, Yaping Xu

https://doi.org/10.18632/aging.205637pp 4841—4861

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Molecular characteristics and prognostic significances of lysosomal-dependent cell death in kidney renal clear cell carcinoma

Shunliang He, Jiaao Sun, Hewen Guan, Ji Su, Xu Chen, Zhijun Hong, Jianbo Wang

https://doi.org/10.18632/aging.205639pp 4862—4888

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5-Hydroxytryptophan acts as a gap junction inhibitor to limit the spread of chemotherapy-induced cardiomyocyte injury and mitochondrial dysfunction

Wenshe Sun, Qi Lu, Yukun Zhang, Dongming Xing

https://doi.org/10.18632/aging.205641pp 4889—4903

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MicroRNA-18a prevents senescence of mesenchymal stem cells by targeting CTDSPL

Bo Sun, Xian-Hui Meng, Yu-Min Li, Hao Lin, Zhong-Dang Xiao

https://doi.org/10.18632/aging.205642pp 4904—4919

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Establishment of an immunogenic cell death-related model for prognostic prediction and identification of therapeutic targets in endometrial carcinoma

Zhenran Liu, Yue Huang, Pin Zhang, Chen Yang, Yujie Wang, Yaru Yu, Huifen Xiang

https://doi.org/10.18632/aging.205647pp 4920—4942

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Correction

Correction: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

Kara N. Fitzgerald, Romilly Hodges, Douglas Hanes, Emily Stack, David Cheishvili, Moshe Szyf, Janine Henkel, Melissa W. Twedt, Despina Giannopoulou, Josette Herdell, Sally Logan, Ryan Bradley

https://doi.org/10.18632/aging.205700pp 4943—4945

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Retraction

Retraction: Silencing lncRNA XIST exhibits antiproliferative and proapoptotic effects on gastric cancer cells by up-regulating microRNA-132 and down-regulating PXN

Ping Li, Liuhua Wang, Pengfei Li, Fangyong Hu, Yi Cao, Dong Tang, Gang Ye, Hongbo Li, Daorong Wang

https://doi.org/10.18632/aging.205702pp 4946—4947

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