Research Paper Volume 16, Issue 5 pp 4832—4840
Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation
- 1 Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 40202, Taiwan
- 2 Division of Family Medicine, China Medical University Hsinchu Hospital, Hsinchu 30272, Taiwan
- 3 Physical Examination Center, China Medical University Hsinchu Hospital, Hsinchu 30272, Taiwan
- 4 Department of Medical Research, China Medical University Hsinchu Hospital, Hsinchu 30272, Taiwan
- 5 Department of Pharmacology, School of Medicine, China Medical University, Taichung 40202, Taiwan
- 6 Chinese Medicine Research Center, China Medical University, Taichung 40202, Taiwan
- 7 Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40202, Taiwan
- 8 School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung 40202, Taiwan
- 9 Department of Chinese Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan
- 10 Department of Chinese Medicine, China Medical University Hospital Taipei Branch, Taipei 11449, Taiwan
- 11 School of Chinese Medicine, China Medical University, Taichung 40202, Taiwan
- 12 Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan
Received: September 18, 2023 Accepted: February 13, 2024 Published: March 9, 2024
https://doi.org/10.18632/aging.205635How to Cite
Copyright: © 2024 Ho et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Osteoporosis is a usual bone disease in aging populations, principally in postmenopausal women. Anti-resorptive and anabolic drugs have been applied to prevent and cure osteoporosis and are associated to a different of adverse effects. Du-Zhong is usually applied in Traditional Chinese Medicine to strengthen bone, regulate bone metabolism, and treat osteoporosis. Chlorogenic acid is a major polyphenol in Du-Zhong. In the current study, chlorogenic acid was found to enhance osteoblast proliferation and differentiation. Chlorogenic acid also inhibits the RANKL-induced osteoclastogenesis. Notably, ovariectomy significantly decreased bone volume and mechanical properties in the ovariectomized (OVX) rats. Administration of chlorogenic acid antagonized OVX-induced bone loss. Taken together, chlorogenic acid seems to be a hopeful molecule for the development of novel anti-osteoporosis treatment.