Research Paper Volume 16, Issue 5 pp 4579—4590
A novel classification predicts prognosis and drug sensitivity in osteosarcoma based on alterations in gene sets
- 1 Department of Spine Surgery, Ganzhou People’s Hospital, Ganzhou, Jiangxi, China
Received: October 23, 2023 Accepted: January 23, 2024 Published: February 28, 2024
https://doi.org/10.18632/aging.205614How to Cite
Copyright: © 2024 Ye et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Osteosarcoma is a cancer originating in the bone cells, specifically in the osteoblasts. Previous studies mainly focused on particular molecules but the whole pathway network. We comprehensively analyzed the enrichment score of each signal pathway and identified a novel classification by 20 machine learning algorithms. Furthermore, differences in tumor immune infiltration cells and drug sensitivity were compared in low and high groups. We identified a model consisting of four signaling pathways that predict the prognosis and the immune status of the tumor microenvironment and drug sensitivity in osteosarcoma patients. The novel classification may be used in clinical applications to predict prognosis and drug sensitivity.