Volume 11, Issue 18

30 September, 2019
pp 7329—8035

About the Cover

The cover features Figure 7 "Schematic representation of the effects of the modulation of THs levels in healthspan and lifespan in mice" from López-Noriega et al.

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Editorials

Electrolytes and electrophysiology: what’s next?

Raymond Noordam, William J. Young, Patricia B. Munroe,

https://doi.org/10.18632/aging.102267 pp 7329—7330

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Adipogenic progenitors keep muscle stem cells young

Sara Ancel, Omid Mashinchian, Jerome N. Feige,

https://doi.org/10.18632/aging.102304 pp 7331—7333

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Cholesterol induces T cell exhaustion

Xingzhe Ma, Qing Yi,

https://doi.org/10.18632/aging.102305 pp 7334—7335

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Lamin B1 in cancer and aging

Boyan K. Garvalov, Sajjad Muhammad, Gergana Dobreva,

https://doi.org/10.18632/aging.102306 pp 7336—7338

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Research Papers

Leonurine ameliorates D-galactose-induced aging in mice through activation of the Nrf2 signalling pathway

Peng Chen, Fuchao Chen, Ben-hong Zhou,

https://doi.org/10.18632/aging.101733 pp 7339—7356

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miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells

Xueni Xu, Xiaoxiang Chen, Mu Xu, Xiangxiang Liu, Bei Pan, Jian Qin, Tao Xu, Kaixuan Zeng, Yuqin Pan, Bangshun He, Huiling Sun, Li Sun, Shukui Wang,

https://doi.org/10.18632/aging.102214 pp 7357—7385

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lncRNA DLEU2 modulates cell proliferation and invasion of non-small cell lung cancer by regulating miR-30c-5p/SOX9 axis

Yongchun Zhou, Hutao Shi, Yaqian Du, Guangqiang Zhao, Xiaoxiong Wang, Quan Li, Junxi Liu, Lianhua Ye, Zhenghai Shen, Yinjin Guo, Yunchao Huang,

https://doi.org/10.18632/aging.102226 pp 7386—7401

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CCL28 promotes locomotor recovery after spinal cord injury via recruiting regulatory T cells

Pengfei Wang, Xiangbei Qi, Guohui Xu, Jianning Liu, Jichao Guo, Xu Li, Xinzhe Ma, Hui Sun,

https://doi.org/10.18632/aging.102239 pp 7402—7415

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Hearing consequences in Gjb2 knock-in mice: implications for human p.V37I mutation

Xin Lin, Gen Li, Yu Zhang, Jingjing Zhao, Jiawen Lu, Yunge Gao, Huihui Liu, Geng-Lin Li, Tao Yang, Lei Song, Hao Wu,

https://doi.org/10.18632/aging.102246 pp 7416—7441

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Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer

Xuan Jing, Hongping Liang, Chonghua Hao, Li Hongxia, Xiangrong Cui,

https://doi.org/10.18632/aging.102250 pp 7442—7456

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Increased interleukin-18 level contributes to the development and severity of ischemic stroke

Yong Hao, Jie Ding, Ronghua Hong, Shuwei Bai, Ze Wang, Chengjun Mo, Qiang Hu, Zezhi Li, Yangtai Guan,

https://doi.org/10.18632/aging.102253 pp 7457—7472

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HnRNPR-CCNB1/CENPF axis contributes to gastric cancer proliferation and metastasis

Er-Bao Chen, Xuan Qin, Ke Peng, Qian Li, Cheng Tang, Yi-Chou Wei, Shan Yu, Lu Gan, Tian-Shu Liu,

https://doi.org/10.18632/aging.102254 pp 7473—7491

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PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation

Ting Qiu, Yaqiong Tian, Yujuan Gao, Miao Ma, Hui Li, Xiaoqin Liu, Hongyan Wu, Yingwei Zhang, Hui Ding, Mengshu Cao, Ji Zhang, Jinghong Dai, Jingyu Chen, Hourong Cai,

https://doi.org/10.18632/aging.102262 pp 7492—7509

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MiR-27a promotes insulin resistance and mediates glucose metabolism by targeting PPAR-γ-mediated PI3K/AKT signaling

Tianbao Chen, Yi Zhang, Yilan Liu, Dexiao Zhu, Jing Yu, Guoqian Li, Zhichun Sun, Wanru Wang, Hongwei Jiang, Zhenzhen Hong,

https://doi.org/10.18632/aging.102263 pp 7510—7524

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Identification of a novel microRNA recurrence-related signature and risk stratification system in breast cancer

Jianguo Lai, Bo Chen, Guochun Zhang, Yulei Wang, Hsiaopei Mok, Lingzhu Wen, Zihao Pan, Fengxi Su, Ning Liao,

https://doi.org/10.18632/aging.102268 pp 7525—7536

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Hydrogen sulfide is a novel regulator implicated in glucocorticoids-inhibited bone formation

Jun Ma, Changgui Shi, Zhongyang Liu, Bin Han, Lei Guo, Lei Zhu, Tianwen Ye,

https://doi.org/10.18632/aging.102269 pp 7537—7552

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Long non-coding RNA TUG1 enhances chemosensitivity in non-small cell lung cancer by impairing microRNA-221-dependent PTEN inhibition

Shenghu Guo, Lei Zhang, Yuehua Zhang, Zheng Wu, Dongwei He, Xing Li, Zhiyu Wang,

https://doi.org/10.18632/aging.102271 pp 7553—7569

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Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation

Qian Su, Peng Zhang, Dong Yu, Zhaodi Wu, Dandan Li, Fangfang Shen, Pengfei Liao, Guizhi Yin,

https://doi.org/10.18632/aging.102272 pp 7570—7586

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Attenuated activation of the unfolded protein response following exercise in skeletal muscle of older adults

Corey R. Hart, Zachary C. Ryan, Kyle T. Pfaffenbach, Surendra Dasari, Mojtaba Parvizi, Antigoni Z. Lalia, Ian R. Lanza,

https://doi.org/10.18632/aging.102273 pp 7587—7604

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Adherence to a healthy lifestyle counteracts the negative effects of risk factors on all-cause mortality in the oldest-old

Zhi Cao, Rui Wang, Yangyang Cheng, Hongxi Yang, Shu Li, Li Sun, Weili Xu, Yaogang Wang,

https://doi.org/10.18632/aging.102274 pp 7605—7619

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Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice

Huimin Li, Xinhui Wang, Xinyue Lu, Hongxin Zhu, Sheng Li, Shiwei Duan, Xinzhi Zhao, Fuquan Zhang, Gil Alterovitz, Fudi Wang, Qiang Li, Xiao-Li Tian, Mingqing Xu,

https://doi.org/10.18632/aging.102275 pp 7620—7638

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miR-125a-5p inhibits tumorigenesis in hepatocellular carcinoma

Xin Xu, Yuquan Tao, Yongjie Niu, Zhixian Wang, Congcong Zhang, Yongchun Yu, Lifang Ma,

https://doi.org/10.18632/aging.102276 pp 7639—7662

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Association between promoter DNA methylation and gene expression in the pathogenesis of ischemic stroke

Guo-Xiong Deng, Ning Xu, Qi Huang, Jin-Yue Tan, Zhao Zhang, Xian-Feng Li, Jin-Ru Wei,

https://doi.org/10.18632/aging.102278 pp 7663—7677

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Long noncoding RNA TTN-AS1 enhances the malignant characteristics of osteosarcoma by acting as a competing endogenous RNA on microRNA-376a thereby upregulating dickkopf-1

Shenglong Li, Fei Liu, Yi Pei, Wei Wang, Ke Zheng, Xiaojing Zhang,

https://doi.org/10.18632/aging.102280 pp 7678—7693

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Circulating glucuronic acid predicts healthspan and longevity in humans and mice

Andrew Ho, Jonah Sinick, Tõnu Esko, Krista Fischer, Cristina Menni, Jonas Zierer, Maria Matey-Hernandez, Kristen Fortney, Eric K. Morgen,

https://doi.org/10.18632/aging.102281 pp 7694—7706

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Single-cell RNA-seq reveals RAD51AP1 as a potent mediator of EGFRvIII in human glioblastomas

Qixue Wang, Yanli Tan, Chuan Fang, Junhu Zhou, Yunfei Wang, Kai Zhao, Weili Jin, Ye Wu, Xiaomin Liu, Xing Liu, Chunsheng Kang,

https://doi.org/10.18632/aging.102282 pp 7707—7722

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Neural stem cell small extracellular vesicle-based delivery of 14-3-3t reduces apoptosis and neuroinflammation following traumatic spinal cord injury by enhancing autophagy by targeting Beclin-1

Yuluo Rong, Wei Liu, Chengtang Lv, Jiaxing Wang, Yongjun Luo, Dongdong Jiang, Linwei Li, Zheng Zhou, Wei Zhou, Qingqing Li, Guoyong Yin, Lipeng Yu, Jin Fan, Weihua Cai,

https://doi.org/10.18632/aging.102283 pp 7723—7745

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Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging

Livia López-Noriega, Vivian Capilla-González, Nadia Cobo-Vuilleumier, Eugenia Martin-Vazquez, Petra Isabel Lorenzo, Enrique Martinez-Force, Mario Soriano-Navarro, María García-Fernández, Silvana Yanina Romero-Zerbo, Francisco Javier Bermúdez-Silva, Irene Díaz-Contreras, Ana Sánchez-Cuesta, Carlos Santos-Ocaña, Abdelkrim Hmadcha, Bernat Soria, Franz Martín, Benoit Raymond Gauthier, Alejandro Martin-Montalvo,

https://doi.org/10.18632/aging.102285 pp 7746—7779

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Sulfated polysaccharide of Sepiella maindroni ink targets Akt and overcomes resistance to the FGFR inhibitor AZD4547 in bladder cancer

Liping Shan, Wei Liu, Yunhong Zhan,

https://doi.org/10.18632/aging.102286 pp 7780—7795

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Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer

Patrick Lebok, Aurelia von Hassel, Jan Meiners, Claudia Hube-Magg, Ronald Simon, Doris Höflmayer, Andrea Hinsch, David Dum, Christoph Fraune, Cosima Göbel, Katharina Möller, Guido Sauter, Frank Jacobsen, Franziska Büscheck, Kristina Prien, Till Krech, Rainer Horst Krech, Albert von der Assen, Linn Wölber, Isabell Witzel, Barbara Schmalfeldt, Stefan Geist, Peter Paluchoswski, Christian Wilke, Uwe Heilenkötter, Luigi Terracciano, Volkmar Müller, Waldemar Wilczak, Eike Christian Burandt,

https://doi.org/10.18632/aging.102287 pp 7796—7804

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A novel chalcone derivative exerts anti-inflammatory and anti-oxidant effects after acute lung injury

Yuting Lin, Man Zhang, Qingdi Lu, Jingwen Xie, Jianzhang Wu, Chengshui Chen,

https://doi.org/10.18632/aging.102288 pp 7805—7816

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PRL-3 exerts oncogenic functions in myeloid leukemia cells via aberrant dephosphorylation of stathmin and activation of STAT3 signaling

Jianping Xu, Wei Wu, Yao Tang, Yanfeng Lin, Yan Xue, Jianda Hu, Donghong Lin,

https://doi.org/10.18632/aging.102290 pp 7817—7829

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Downregulation of LncRNA-XIST inhibited development of non-small cell lung cancer by activating miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death

Jinglei Liu, Lei Yao, Mingyan Zhang, Ji Jiang, Maopeng Yang, Yue Wang,

https://doi.org/10.18632/aging.102291 pp 7830—7846

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KLB gene polymorphism is associated with obesity and non-alcoholic fatty liver disease in the Han Chinese

Fang Ji, Ye Liu, Jun-Gui Hao, Li-Ping Wang, Ming-Jia Dai, Gui-Fang Shen, Xue-Bing Yan,

https://doi.org/10.18632/aging.102293 pp 7847—7858

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Up regulation of Rho-associated coiled-coil containing kinase1 (ROCK1) is associated with genetic instability and poor prognosis in prostate cancer

Stefan Steurer, Benjamin Hager, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Sarah Minner, Till S. Clauditz, Claudia Hube-Magg, Andreas M. Luebke, Ronald Simon, Jakob R. Izbicki, Eike Burandt, Guido Sauter, Christoph Fraune, Sören Weidemann, Thorsten Schlomm, Hans Heinzer, Alexander Haese, Markus Graefen, Hartwig Huland, Asmus Heumann,

https://doi.org/10.18632/aging.102294 pp 7859—7879

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Mechanisms of ROS-induced mitochondria-dependent apoptosis underlying liquid storage of goat spermatozoa

Tengfei Liu, Yawen Han, Ting Zhou, Ruihang Zhang, Hong Chen, Shulin Chen, Huiying Zhao,

https://doi.org/10.18632/aging.102295 pp 7880—7898

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Fibroblast growth factor 23 expression in human calcified vascular tissues

Javier Donate-Correa, Ernesto Martín-Núñez, Carolina Hernández-Carballo, Carla Ferri, Víctor G. Tagua, Alejandro Delgado-Molinos, Ángel López-Castillo, Sergio Rodríguez-Ramos, Purificación Cerro-López, Victoria Castro López-Tarruella, Raquel Felipe-García, Miguel A. Arévalo-Gomez, Nayra Pérez-Delgado, Carmen Mora-Fernández, Juan F. Navarro-González,

https://doi.org/10.18632/aging.102297 pp 7899—7913

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TIP-B1 promotes kidney clear cell carcinoma growth and metastasis via EGFR/AKT signaling

Lei Yin, Shenglin Gao, Heng Shi, Keyi Wang, Huan Yang, Bo Peng,

https://doi.org/10.18632/aging.102298 pp 7914—7937

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The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis

Ebrahim Bani Hassan, Mostafa Alderghaffar, Fabien Wauquier, Veronique Coxam, Oddom Demontiero, Sara Vogrin, Yohann Wittrant, Gustavo Duque,

https://doi.org/10.18632/aging.102299 pp 7938—7947

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Prevalence and prognosis significance of cardiovascular disease in cancer patients: a population-based study

Dong Liu, Zhiqiang Ma, Jingang Yang, Min Zhao, Huiping Ao, Xiaodong Zheng, Qianfa Wen, Yuejin Yang, Jiangyun You, Shubin Qiao, Jiansong Yuan,

https://doi.org/10.18632/aging.102301 pp 7948—7960

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Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway

Yanqiu Wang, Rui Zuo, Ziwen Wang, Liwen Luo, Junlong Wu, Chao Zhang, Minghan Liu, Chunmeng Shi, Yue Zhou,

https://doi.org/10.18632/aging.102302 pp 7961—7977

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GSK-3β and ERK1/2 incongruously act in tau hyperphosphorylation in SPS-induced PTSD rats

Zhen Wei, Yacoubou Abdoul Razak Mahaman, Feiqi Zhu, Mengjuan Wu, Yiyuan Xia, Kuan Zeng, Ying Yang, Rong Liu, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wang,

https://doi.org/10.18632/aging.102303 pp 7978—7995

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Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury

Ruoqiong Huang, Chaojin Qin, Jiangmei Wang, Yaoqin Hu, Guoping Zheng, Guanguan Qiu, Menghua Ge, Huikang Tao, Qiang Shu, Jianguo Xu,

https://doi.org/10.18632/aging.102314 pp 7996—8014

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Circular RNA profiling in the oocyte and cumulus cells reveals that circARMC4 is essential for porcine oocyte maturation

Zubing Cao, Di Gao, Tengteng Xu, Ling Zhang, Xu Tong, Dandan Zhang, Yiqing Wang, Wei Ning, Xin Qi, Yangyang Ma, Kaiyuan Ji, Tong Yu, Yunsheng Li, Yunhai Zhang,

https://doi.org/10.18632/aging.102315 pp 8015—8034

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Correction

Correction for: Aged cells in human skeletal muscle after resistance exercise

Chi Yang, Ying Jiao, Bing Wei, Zeyi Yang, Jin-Fu Wu, Jorgen Jensen, Wei-Horng Jean, Chih-Yang Huang, Chia-Hua Kuo,

https://doi.org/10.18632/aging.102338 pp 8035

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