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Research Paper|Volume 11, Issue 18|pp 7938—7947

The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis

Ebrahim Bani Hassan1,2, Mostafa Alderghaffar3, Fabien Wauquier4, Veronique Coxam4, Oddom Demontiero3, Sara Vogrin1,2, Yohann Wittrant4, Gustavo Duque1,2
  • 1Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia
  • 2Department of Medicine-Western Health, The University of Melbourne, St. Albans, VIC, Australia
  • 3Ageing Bone Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, Australia
  • 4Human Nutrition Unit, UMR1019, INRA/Université Clermont Auvergne, Clermont-Ferrand, France
Received: August 9, 2019Accepted: September 14, 2019Published: September 25, 2019
https://doi.org/10.18632/aging.102299

Copyright © 2019 Bani Hassan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Purpose: Marrow adipose tissue (MAT) expansion and associated lipotoxicity are important drivers of age-related bone loss and hematopoietic bone marrow (HBM) atrophy. Fish oil and borage oil (rich in ω3 fatty acids) can partially prevent aged-related bone loss in SAMP8 mice. However, whether preservation of bone mass in this progeria model is associated with MAT volumes remains unknown.

Results: MAT volume fraction (MAT%) showed a negative association with hematopoietic bone marrow (HBM%;r=-0.836, p<0.001) and bone (bone%;r=-0.344, p=0.013) volume fractions.

Adjusting for multiple comparisons, bone% was higher and MAT% was lower in Fish oil (FO)-supplemented groups vs. controls (p<0.001). HBM% did not differ significantly between the four groups. However, in the group supplemented with FO, HBM comprised higher fractions and MAT constituted lower fractions of total marrow vs. controls (p<0.001).

Conclusion: Feeding FO-enriched diet prevented age-related bone and HBM loss, by reducing MAT expansion. Our results further emphasize on the role(s) of MAT expansion in bone and HBM atrophy.

Methods: SAMP8 mice (n>9 /group) were allocated into 4 categories and fed a control ration, FO-, sunflower oil (SFO)- and borage oil-enriched diets for lifetime. Femurs were scanned using microcomputed tomography (μCT) and bone, MAT, and HBM volumes were determined using an image analysis software.