Special Collection on Cell Senescence and Rapamycin

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Gerosuppression by pan-mTOR inhibitors

Olga V. Leontieva, Mikhail V. Blagosklonny

https://doi.org/10.18632/aging.101155pp 3535—3551

Identification of Salvia haenkei as gerosuppressant agent by using an integrated senescence-screening assay

Ivana Matic, Ajinkya Revandkar, Jingjing Chen, Angela Bisio, Stefano Dall’Acqua, Veronica Cocetta, Paola Brun, Giorgio Mancino, Martina Milanese, Maurizio Mattei, Monica Montopoli, Andrea Alimonti

https://doi.org/10.18632/aging.101076pp 3223—3240

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Rapamycin reverses the senescent phenotype and improves immuno-regulation of mesenchymal stem cells from MRL/lpr mice and systemic lupus erythematosus patients through inhibition of the mTOR signaling pathway

Zhifeng Gu, Wei Tan, Juan Ji, Guijian Feng, Yan Meng, Zhanyun Da, Genkai Guo, Yunfei Xia, Xinhang Zhu, Guixiu Shi, Chun Cheng

https://doi.org/10.18632/aging.100925pp 1102—1114

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Reversal of phenotypes of cellular senescence by pan-mTOR inhibition

Hannah E. Walters, Sylwia Deneka-Hannemann, Lynne S. Cox

https://doi.org/http://dx.doi.org/10.18632/aging.100872pp 231—244

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A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition

Clemens Stockklausner, Simon Raffel, Julia Klermund, Obul Reddy Bandapalli, Fabian Beier, Tim H. Brümmendorf, Friederike Bürger, Sven W. Sauer, Georg F. Hoffmann, Holger Lorenz, Laura Tagliaferri, Daniel Nowak, Wolf-Karsten Hofmann, Rebecca Buergermeister, Carolin Kerber, Tobias Rausch, Jan O. Korbel, Brian Luke, Andreas Trumpp, Andreas E. Kulozik

https://doi.org/http://dx.doi.org/10.18632/aging.100835pp 911—927

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Gerosuppression in confluent cells

Olga V. Leontieva, Mikhail V. Blagosklonny

https://doi.org/http://dx.doi.org/10.18632/aging.100714pp 1010—1018

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Berberine suppresses gero-conversion from cell cycle arrest to senescence

Hong Zhao, H Dorota Halicka, Jiangwei Li, Zbigniew Darzynkiewicz

https://doi.org/http://dx.doi.org/10.18632/aging.100593pp 623—636

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mTOR pathway and Ca²⁺ stores mobilization in aged smooth muscle cells

Francisco E. Martín-Cano, Cristina Camello-Almaraz, David Hernandez, Maria J. Pozo, Pedro J. Camello

https://doi.org/http://dx.doi.org/10.18632/aging.100555pp 339—346

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Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling

H. Dorota Halicka, Hong Zhao, Jiangwei Li, Yong-Syu Lee, Tze-Chen Hsieh, Joseph M. Wu, Zbigniew Darzynkiewicz

https://doi.org/http://dx.doi.org/10.18632/aging.100521pp 952—965

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Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

Mikhail V. Blagosklonny

https://doi.org/http://dx.doi.org/10.18632/aging.100475pp 450—455

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Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

Mikhail V. Blagosklonny

https://doi.org/http://dx.doi.org/10.18632/aging.100443pp 159—165

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Mitochondrial dysfunction and cell senescence — skin deep into mammalian aging

Joao F. Passos, Thomas von Zglinicki

https://doi.org/http://dx.doi.org/10.18632/aging.100432pp 74—75

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Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression

Olga V. Leontieva, Mikhail V. Blagosklonny

https://doi.org/http://dx.doi.org/10.18632/aging.100402pp 1078—1091

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Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling

H. Dorota Halicka, Hong Zhao, Jiangwei Li, Frank Traganos, Sufang Zhang, Marietta Lee, Zbigniew Darzynkiewicz

https://doi.org/http://dx.doi.org/10.18632/aging.100397pp 1028—1038

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Be quiet and you'll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?

Vjekoslav Dulic

https://doi.org/http://dx.doi.org/10.18632/aging.100257pp 3—4

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DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence

Olga V. Leontieva, Mikhail V. Blagosklonny

https://doi.org/http://dx.doi.org/10.18632/aging.100265pp 924—935

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Adult-onset, short-term dietary restriction reduces cell senescence in mice

Chunfang Wang, Mandy Maddick, Satomi Miwa, Diana Jurk, Rafal Czapiewski, Gabriele Saretzki, Sabine A.S. Langie, Roger W.L. Godschalk, Kerry Cameron, Thomas von Zglinicki

https://doi.org/http://dx.doi.org/10.18632/aging.100196pp 555—566

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