Research Perspective|Volume 4, Issue 7|pp 450—455

Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

Mikhail V. Blagosklonny¹

¹Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

Received: July 15, 2012Accepted: July 30, 2012Published: July 31, 2012

Abstract

I discuss a very obscure activity of p53, namely suppression of senescence (gerosuppression), which is also manifested as anti-hypertrophic, anti-hypermetabolic, anti-inflammatory and anti-secretory effects of p53. But can gerossuppression suppress tumors?