Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

Mikhail V. Blagosklonny

doi:10.18632/aging.100475

Research Perspective Volume 4, Issue 7 pp 450—455

Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

Mikhail V. Blagosklonny^1, ,

¹ Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

Received: July 15, 2012 Accepted: July 30, 2012 Published: July 31, 2012

https://doi.org/10.18632/aging.100475
How to Cite

Abstract

I discuss a very obscure activity of p53, namely suppression of senescence (gerosuppression), which is also manifested as anti-hypertrophic, anti-hypermetabolic, anti-inflammatory and anti-secretory effects of p53. But can gerossuppression suppress tumors?

View Full Text Download PDF

Research Perspective Volume 4, Issue 7 pp 450—455

Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

Mikhail V. Blagosklonny^1, ,

Received: July 15, 2012 Accepted: July 30, 2012 Published: July 31, 2012

Abstract

Corresponding Author

Special Collection

Keywords

Research Perspective Volume 4, Issue 7 pp 450—455

Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

Mikhail V. Blagosklonny1, ,

Received: July 15, 2012 Accepted: July 30, 2012 Published: July 31, 2012

Cite this Article

How to cite

Copy or Download citation:

Abstract

Corresponding Author

Special Collection

Keywords

Mikhail V. Blagosklonny^1, ,