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Online ISSN: 1945-4589
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02-02-2021
Aging-US published " Screening of Alzheimer’s disease by facial complexion using artificial intelligence " which reported that despite the increasing incidence and high morbidity associated with dementia, a simple, non-invasive, and inexpensive method of screening for dementia is yet to be discovered. This study aimed…
01-19-2021
Aging-US Issue 1 Volume 13 features " PAM (PIK3/AKT/mTOR) signaling in glia: potential contributions to brain tumors in aging " which reported that despite a growing proportion of aged individuals at risk for developing cancer in the brain, the prognosis for these conditions remains abnormally poor due to limited…
01-19-2021
Aging-US published " Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment " which reported that here, the authors investigated nicotinamide mononucleotide , a precursor of nicotinamide adenine dinucleotide , in a retinal…
12-15-2020
Aging-US recently published " Transforming growth factor beta type 1 (TGF-β) and hypoxia-inducible factor 1 (HIF-1) transcription complex as master regulators of the immunosuppressive protein galectin-9 expression in human cancer and embryonic cells " which reported that for the first time that in human cancer as well…
11-16-2020
Aging-US recently published " Identification of genomic alterations and associated transcriptomic profiling reveal the prognostic significance of MMP14 and PKM2 in patients with pancreatic cancer " which reported that Integrated analysis of The Cancer Genome Atlas datasets revealed that KRAS mutation, TP53 mutation…
11-13-2020
Aging-US recently published " Knockdown of TXNDC9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation " which reported that no research associated with TXNDC9 has been reported in glioma. In this study, the found that TXNDC9 was upregulated in glioma. Knockdown of TXNDC9 would…
11-13-2020
Aging-US recently published " Alzheimer’s disease as a systems network disorder: chronic stress/dyshomeostasis, innate immunity, and genetics " which reported that ineffective results of clinical trials of over 200 anti-Alzheimer's drug candidates, with a 99.6% attrition rate, suggest that the current paradigm of…
11-10-2020
Aging-US recently published " MiR-520d-5p modulates chondrogenesis and chondrocyte metabolism through targeting HDAC1 " which reported that this study aimed to determine miRNAs associated with chondrogenesis of human mesenchymal stem cells and chondrocyte metabolism. MiRNAs were screened in hMSCs during chondrogenesis…
11-10-2020
Aging-US recently published " Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1) " which reported that MiR-132 and miR-212 were up-regulated in HAEC dilated tissues and LPS-treated mice enteritis…
11-10-2020
Aging-US recently published " GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis through AMPK pathway " which reported that pyroptosis and NLRP3 inflammasome are associated with various kinds of inflammatory diseases including colitis. In vivo, the authors found GPA peptide could exert…
11-10-2020
Aging-US recently published " Characterization of LncRNA SNHG22 as a protector of NKIRAS2 through miR-4492 binding in osteosarcoma \” which reported that the underlying mechanism of SNHG22 in regulating OS progression remains unknown. In this study, the authors confirmed that SNHG22 was downregulated in OS, and the…
11-10-2020
Aging-US recently published " Psychological aging, depression, and well-being " which reported that Aging is a multifactorial process, which affects the human body on every level and results in both biological and psychological changes. These factors can be used for a future development of individual psychological…
10-05-2020
Aging-US recently published " From Causes of Aging to Death from COVID-19 " by Blagosklonny et al. which reported that COVID-19 is not deadly early in life, but mortality increases exponentially with age - which is the strongest predictor of mortality. The Review covers: Age Age-related diseases Male Gender Mortality…
06-29-2020
The cover for issue 12 of Aging-US features " SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair " by Rezazadeh et al. and reported that when transcribed DNA is damaged, the transcription and DNA repair machinery must interact to ensure…
04-20-2020
Volume 12, Issue 8 of @AgingJrnl reported that similarly, two proposed therapeutics for the treatment of COVID-19 infection are Azithromycin and Quercetin, both drugs with significant senolytic activity. Therefore, the authors wish to speculate that the fight against COVID-19 disease should involve testing the…
04-03-2020
Friday, 3rd of April, 2020, London, UK - The Biogerontology Research Foundation, a registered UK charity supporting and promoting aging and longevity research worldwide since 2008, today announced the publication of a paper titled “ Geroprotective and senoremediative strategies to reduce the comorbidity, infection…
02-13-2020
Aging-US Volume 12, Issue 2 reported that Younger females are protected from adipose inflammation, but older post-menopausal females exhibit exaggerated visceral adiposity correlated with increased disease risk. Obesity accelerates the onset and progression of age-associated diseases, but it is unclear if aging and…
02-13-2020
The cover features Figure 9 "Resveratrol enhances antitumor T cell immunity by promoting abnormal glycosylation and dimerization of PD-L1." from Verdura et al. . RSV was also predicted to interact with the inner surface of PD-L1 involved in the interaction with PD-1, almost perfectly occupying the target space of the…
02-13-2020
The cover features Figure 7 "Scheme of epigenetic and molecular mechanisms changed in 5XFAD mice induced by pharmacological inhibition of G9a/GLP by UNC0642" from Griñán-Ferré et al . UNC0642, a specific and potent inhibitor of methyltransferase activity G9a/GLP complex, was evaluated in the 5XFAD mouse model. UNC0642…
12-03-2019
Deep biomarkers of aging and longevity: from research to applications The deep age predictors can help advance aging research by establishing causal relationships in nonlinear systems . Deep aging clocks can be used for identification of novel therapeutic targets, evaluating the efficacy of various interventions, data…