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Page 26 of 26 · 502 total

Sex differences in transcriptomic profiles in aged kidney cells of renin lineage (CoRL)

06-01-2018

The researchers found a small core set of genes involved in stemness, proliferation and migration that showed consistent changes with advanced age in cells of renin lineage (CoRL)within the kidney. Surprisingly, most gene expression changes in CoRL aging are sex-specific: aged female mice showed up-regulation of…

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Exploiting mitochondrial targeting signal(s), TPP and bis‐TPP, for eradicating cancer stem cells (CSCs)

06-01-2018

TPP-related compounds may provide a novel chemical strategy for effectively targeting bulk cancer cells and CSCs, while minimizing off-target side-effects in normal cells. Several independent lines of evidence support the idea that increased mitochondrial biogenesis or higher levels of mitochondrial protein…

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