Navigate
Online ISSN: 1945-4589
Learn about our FREE Post-
Publication Promotion Services
11-18-2019
The cover features Figure 3 "Calculated bioenergetic health index (BHI) from young and old CD4+ T cells" from Bektas et al. Though mitochondrial number in both naive and memory cells visualized with electron microcopy was similar in older versus younger participants, there were a significantly higher number of…
11-05-2019
The cover features Figure 4 "SAMP8 mice display a spontaneous OA phenotype" from Malaise The research team tests whether by becoming senescent, the mesenchymal stromal/stem cells, found in the synovial tissue and sub-chondral bone marrow, can contribute to OA development. When co-cultured with OA chondrocytes,…
10-14-2019
The scientist discusses several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects preclude their use as anti-aging drugs today. They go on to discuss why it is more dangerous not to use anti-aging drugs than…
10-06-2019
The researchers examined the contribution of N-methyl-D-aspartate receptor subunits in the redox-mediated decline in NMDAR function during aging. Glu N2A and Glu N2B selective antagonists decreased peak NMDAR currents to a similar extent in young and aged animals, indicating that a shift in diheteromeric Glu N2…
10-05-2019
Due to strain-specific behavioral idiosyncrasies, inbred mouse strains are suboptimal research models for behavioral aging studies. The researchers found that both males and females demonstrated decreased exploratory behavior with age, while memory and depressive-like behavior were maintained. Dr. Malin Hernebring…
10-04-2019
The researchers recruited healthy older participants to two groups according to their history of tea drinking frequency and investigated both functional and structural networks to reveal the role of tea drinking on brain organization. The suppression of hemispheric asymmetry in the structural connectivity network was…
10-03-2019
In adult skeletal muscle, loss of myofiber integrity caused by mechanical injuries or diseases are repaired by resident muscle stem cells, called satellite cells, which promptly exit from quiescence after disruption of muscle architecture to expand, differentiate and drive tissue regeneration. Dr. Jerome N. Feige from…
10-02-2019
Marrow adipose tissue expansion and associated lipotoxicity are important drivers of age-related bone loss and hematopoietic bone marrow atrophy. Dr. Gustavo Duque from the Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia and the…
09-30-2019
For Aging’s Volume 11, Issue 18, the Journal devoted the Cover to a research paper by Dr. Alejandro Martin-Montalvo from the Department of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of…
08-25-2019
Leukocyte DNAm TL is applicable across the entire age spectrum and is more strongly associated with age than measured leukocyte TL. Leukocyte DNAm TL outperforms LTL in predicting: i)time-to-death, ii)time-to-coronary heart disease, iii)time-to-congestive heart failure and iv)association with smoking history. Dr.…
08-25-2019
In this study, the research team conducted a large-scale epigenome-wide association study of LTL using seven large cohorts the Framingham Heart Study, the Jackson Heart Study, the Womens Health Initiative, the Bogalusa Heart Study, the Lothian Birth Cohorts of 1921 and 1936, and the Longitudinal Study of Aging Danish…
07-30-2019
‘Tickling’ the ear with a small electrical current appears to rebalance the autonomic nervous system for over-55s, potentially slowing down one of the effects of ageing, according to new research. Scientists found that a short daily therapy delivered for two weeks led to both physiological and wellbeing improvements,…
06-04-2019
Cessation, or even retardation of the ageing process is an appealing notion that has captured the imagination of humans for millennia. Even if it were possible to rejuvenate our bodies or retard the ageing process, how do we measure this? Age, as we know it, is clearly an inappropriate measurement because it is based…
06-01-2018
The Grim Reaper arrives for each of us eventually—wouldn’t it be nice to know when? Now UCLA researchers have developed a new tool to help you plan ahead for your date with the Angel of Death. Named after the grim reaper, the biomarker known as DNA methylation GrimAge, allows one to predict lifespan and healthspan,…
06-01-2018
The specific molecular mechanism of selective release and retention of senescence-associated sEV-mi RNAs and the EV-SASP cross talk between different cell types and its consequences in the context of aging and age-associated diseases, however, remains to be elucidated. Dr. Johannes Grillari said " We confirm that EVs…
06-01-2018
The researchers found a small core set of genes involved in stemness, proliferation and migration that showed consistent changes with advanced age in cells of renin lineage (CoRL)within the kidney. Surprisingly, most gene expression changes in CoRL aging are sex-specific: aged female mice showed up-regulation of…
06-01-2018
TPP-related compounds may provide a novel chemical strategy for effectively targeting bulk cancer cells and CSCs, while minimizing off-target side-effects in normal cells. Several independent lines of evidence support the idea that increased mitochondrial biogenesis or higher levels of mitochondrial protein…