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Online ISSN: 1945-4589
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07-25-2021
Aging-US published " MiR-513b-5p represses autophagy during the malignant progression of hepatocellular carcinoma by targeting PIK3R3 " which reported MiR-513b-5p repressed liver cancer cell proliferation, migration/invasion, and induced apoptosis in vitro. Crucially, miR-513b-5p attenuated tumor growth of liver…
07-25-2021
Aging-US published " Identification of RNA binding protein interacting with circular RNA and hub candidate network for hepatocellular carcinoma " which reported that 17 DERBPs, which were commonly dysregulated in HCC from The Clinical Proteomic Tumor Analysis Consortium, The Cancer Genome Atlas and International…
07-25-2021
Aging-US published " PTEN nuclear translocation enhances neuronal injury after hypoxia-ischemia via modulation of the nuclear factor-κB signaling pathway " which reported that this study was designed to investigate phosphatase and tensin homolog nuclear translocation and its possible role in rat cortical neuronal…
07-25-2021
Aging-US published " A novel ferroptosis-related gene signature for prognostic prediction of patients with lung adenocarcinoma " which reported that RNA-seq transcriptome data of LUAD patients were obtained from The Cancer Genome Atlas database. Kaplan–Meier survival and receiver operating characteristic curves were…
07-25-2021
Aging-US published " Facility-based and home-based multidomain interventions including cognitive training, exercise, diet, vascular risk management, and motivation for older adults: a randomized controlled feasibility trial " which reported that in an outcome assessor-blinded, randomized controlled trial, participants…
07-25-2021
Aging-US published " A novel ferroptosis-related gene signature for prognostic prediction of patients with lung adenocarcinoma " which reported that RNA-seq transcriptome data of LUAD patients were obtained from The Cancer Genome Atlas database. Kaplan–Meier survival and receiver operating characteristic curves were…
06-01-2021
Aging published " Cdkn1a transcript variant 2 is a marker of aging and cellular senescence " which reported that cellular senescence is a cell fate response characterized by a permanent cell cycle arrest driven primarily the by cell cycle inhibitor and tumor suppressor proteins p16Ink4a and p21Cip1/Waf1. In mice, the…
05-27-2021
A groundbreaking clinical trial shows we can reduce biological age ( as measured by the Horvath 2013 DNAmAge clock ) by more than three years in only eight weeks with diet and lifestyle through balancing DNA methylation. A first-of-its-kind, peer-reviewed study provides scientific evidence that lifestyle and diet…
05-27-2021
Aging published " Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial " which reported on a randomized controlled clinical trial conducted among 43 healthy adult males between the ages of 50-72. The 8-week treatment program included diet, sleep, exercise and…
05-24-2021
Aging recently published " Intravitreal injection of anti-miRs against miR-142-3p reduces angiogenesis and microglia activation in a mouse model of laser- induced choroidal neovascularization " which reported that MiR-142-3p was overexpressed in murine CNV lesions and its pharmacological inhibition decreased vascular…
03-15-2021
Aging-US published " Functional analysis of POLD1 p.ser605del variant: the aging phenotype of MDPL syndrome is associated with an impaired DNA repair capacity " which reported that Mandibular hypoplasia, Deafness and Progeroid features with concomitant Lipodystrophy define a rare systemic disorder, named MDPL…
03-15-2021
Aging-US published " Impact of adiposity on muscle function and clinical events among elders with dynapenia, presarcopenia and sarcopenia: a community-based cross-sectional study " which reported that low muscle function determined unfavorable clinical outcome than low muscle mass; nevertheless, comparison of…
03-15-2021
Aging-US published " Aging and rejuvenation - a modular epigenome model " which reported that the view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like…
02-17-2021
Aging-US published " In search of preventive strategies: novel high-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues " which reported that Cannabis sativa , especially those high in the anti-inflammatory cannabinoid cannabidiol, has been found to alter gene expression and inflammation…
02-17-2021
Here is a link to a free Altmetric Report on this Research Output Aging-US published " Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial " which reported that the aim of the current study was to evaluate whether hyperbaric oxygen therapy…
02-17-2021
Here is a link to a video interview with Dr. David A. Sinclair about their research on the Aging-US YouTube Channel Here is a link to a free Altmetric Report on this Research Output Aging-US published " Why does COVID-19 disproportionately affect older people? " which reported that the severity and outcome of…
02-17-2021
Aging-US published " DNA- and telomere-damage does not limit lifespan: evidence from rapamycin " which reported that failure of rapamycin to extend lifespan in DNA repair mutant and telomerase-knockout mice, while extending lifespan in normal mice, indicates that neither DNA damage nor telomere shortening limits…
02-02-2021
Aging-US published " Anserine, HClO-scavenger, protected against cognitive decline in individuals with mild cognitive impairment " which reported that In this study, the authors aimed to evaluate the effects of anserine, a scavenger of HClO, on the protection of cognitive declines in persons with MCI. Fifty-eight…
02-02-2021
Aging-US published " A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c " which reported that although ethnic specific mtDNA polymorphisms have been shown to contribute to T2D risk, the functional effects of the mtDNA polymorphisms and the therapeutic potential of mitochondrial-derived…
02-02-2021
Aging-US published " Sulforaphane promotes C. elegans longevity and healthspan via DAF- 16/DAF-2 insulin/IGF-1 signaling " which reported that the broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer , but its effect on healthspan and longevity are unclear. The authors used…