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Volume 15, Issue 22

November 30, 2023pp 12699—13578

About the Cover

The cover features Figure 5 "Aged EVs impact proliferation of young keratinocytes in 2D culture" from Nedachi et al.

Editorial

Artificial intelligence for aging research in cancer drug development

Dorsa Shirini, Lawrence H. Schwartz, Laurent Dercle

https://doi.org/10.18632/aging.204914pp 12699—12701

Research Papers

Chronological aging impacts abundance, function and microRNA content of extracellular vesicles produced by human epidermal keratinocytes

Taku Nedachi, Christelle Bonod, Julie Rorteau, Wafae Chinoune, Yuri Ishiuchi, Sandrine Hughes, Benjamin Gillet, Nicolas Bechetoille, Dominique Sigaudo-Roussel, Jérôme Lamartine

https://doi.org/10.18632/aging.205245pp 12702—12722

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Tat-heat shock protein 10 ameliorates age-related phenotypes by facilitating neuronal plasticity and reducing age-related genes in the hippocampus

Hyo Young Jung, Hyun Jung Kwon, Kyu Ri Hahn, Woosuk Kim, Dae Young Yoo, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang

https://doi.org/10.18632/aging.205182pp 12723—12737

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Contribution of membrane raft redox signalling to visfatin-induced inflammasome activation and podocyte injury

Saisudha Koka, Sreenidhi Surineni, Gurinder Bir Singh, Krishna M. Boini

https://doi.org/10.18632/aging.205243pp 12738—12748

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Nectandrin B significantly increases the lifespan of Drosophila - Nectandrin B for longevity

Ji-Seon Ahn, Nasir Uddin Mahbub, Sura Kim, Han-Byeol Kim, Jong-Soon Choi, Hea-Jong Chung, Seong-Tshool Hong

https://doi.org/10.18632/aging.205234pp 12749—12762

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Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism

Ramya Potabattula, Andreas Prell, Marcus Dittrich, Caroline Nava, Christel Depienne, Yosra Bejaoui, Nady El Hajj, Thomas Hahn, Martin Schorsch, Thomas Haaf

https://doi.org/10.18632/aging.205275pp 12763—12779

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Hypoxic BMSC-derived exosomal miR-652-3p promotes proliferation and metastasis of hepatocarcinoma cancer cells via targeting TNRC6A

Mei Li, Pengtao Zhai, Xudong Mu, Juanrong Song, Huilin Zhang, Juan Su

https://doi.org/10.18632/aging.205025pp 12780—12793

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Identification of mitochondrial-related signature and molecular subtype for the prognosis of osteosarcoma

Xiaokun Zhao, Jian Zhang, Jiahao Liu, Qi Chen, Changxiong Cai, Xinxin Miao, Tianlong Wu, Xigao Cheng

https://doi.org/10.18632/aging.205143pp 12794—12816

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Prognostic hub gene CBX2 drives a cancer stem cell-like phenotype in HCC revealed by multi-omics and multi-cohorts

Qingren Meng, Qian Zhou, Xi Chen, Jun Chen

https://doi.org/10.18632/aging.205173pp 12817—12851

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Peptidome analysis reveals critical roles for peptides in a rat model of intestinal ischemia/reperfusion injury

Jiaxuan Zhang, Xiaoqi Jiang, Yang Yang, Lei Yang, Bing Lu, Yannan Ji, Leijun Guo, Fan Zhang, Jianhua Xue, Xiaofei Zhi

https://doi.org/10.18632/aging.205200pp 12852—12872

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Silencing of Dicer enhances dacarbazine resistance in melanoma cells by inhibiting ADSL expression

Yu-Wen Yeh, Tung-Wei Hsu, Yen-Hao Su, Chih-Hsin Wang, Po-Hsiang Liao, Ching-Feng Chiu, Po-Chen Tseng, Tim-Mo Chen, Woan-Ruoh Lee, Yuan-Sheng Tzeng

https://doi.org/10.18632/aging.205207pp 12873—12889

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TJP3 promotes T cell immunity escape and chemoresistance in breast cancer: a comprehensive analysis of anoikis-based prognosis prediction and drug sensitivity stratification

Liu Chaojun, Li Pengping, Li Yanjun, Zhu Fangyuan, He Yaning, Shao Yingbo, Chen Qi, Liu Hui

https://doi.org/10.18632/aging.205208pp 12890—12906

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The necroptosis signature and molecular mechanism of lung squamous cell carcinoma

Guo-Qiang Song, Hua-Man Wu, Ke-Jie Ji, Tian-Li He, Yi-Meng Duan, Jia-Wen Zhang, Guo-Qiang Hu

https://doi.org/10.18632/aging.205210pp 12907—12926

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A novel telomere-related genes model for predicting prognosis and treatment responsiveness in diffuse large B-cell lymphoma

Zhijia Zhao, Xiaochen Shen, Siqi Zhao, Jinhua Wang, Yuqin Tian, Xiaobo Wang, Bo Tang

https://doi.org/10.18632/aging.205211pp 12927—12951

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EphA2 as a phase separation protein associated with ferroptosis and immune cell infiltration in colorectal cancer

Yanling Li, Qiu Peng, Lujuan Wang

https://doi.org/10.18632/aging.205212pp 12952—12965

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Crucial role of hsa-mir-503, hsa-mir-1247, and their validation in prostate cancer

Ping Hu, Tao Wang, Hui Yan, Ying Huang, Yanjiao Zhao, Yuanyuan Gao

https://doi.org/10.18632/aging.205213pp 12966—12981

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Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer

Ziyi Wu, Nuo Xu, Guoqing Li, Wen Yang, Chen Zhang, Hua Zhong, Gen Wu, Fei Chen, Dianqing Li

https://doi.org/10.18632/aging.205214pp 12982—12997

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The upregulation of circFoxp1 influences keloid by promoting cell proliferation

Jing Zhang, Qianyi Bao, Nan Song, Chunming Li, Jing Ma

https://doi.org/10.18632/aging.205215pp 12998—13009

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Identification of topoisomerase 2A as a novel bone metastasis-related gene in liver hepatocellular carcinoma

Jinyan Feng, Xianfu Wei, Yongheng Liu, Yanting Zhang, Guanghao Li, Yao Xu, Peng Zhou, Jin Zhang, Xiuxin Han, Chao Zhang, Yan Zhang, Guowen Wang

https://doi.org/10.18632/aging.205216pp 13010—13040

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Comprehensive analysis of ZNF692 as a potential biomarker associated with immune infiltration in a pan cancer analysis and validation in hepatocellular carcinoma

Hongjie Cai, Song Chen, Zhiqiang Wu, Fan Wang, Shuangyan Tang, Dongbing Li, Dongliang Wang, Wenbo Guo

https://doi.org/10.18632/aging.205218pp 13041—13058

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Inhibition of UFM1 expression suppresses cancer progression and is linked to the dismal prognosis and immune infiltration in oral squamous cell carcinoma

Di Ke, Hao-Han Guo, Ni Jiang, Rong-Shu Shi, Teng-Yang Fan

https://doi.org/10.18632/aging.205219pp 13059—13076

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Identification of tryptophan metabolism-related genes in immunity and immunotherapy in Alzheimer’s disease

Zhenyan Song, Zixuan Wu, Rongsiqing Luo, Chunxiang He, Ze Li, Miao Yang, Wenjing Yu, Jiawei He, Sisi Deng, Shaowu Cheng

https://doi.org/10.18632/aging.205220pp 13077—13099

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Identification of aneuploidy-related gene signature to predict survival in head and neck squamous cell carcinomas

Yu Liu, Yonghua Yuan, Tao Chen, Hongyi Xiao, Xiangyu Zhang, Fujun Zhang

https://doi.org/10.18632/aging.205221pp 13100—13117

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Clinical significance and immune landscape of angiogenesis-related genes in bladder cancer

Gang Liu, Tingting Zhang, Dingwen Gui, Qin Liu

https://doi.org/10.18632/aging.205222pp 13118—13133

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Prevalence and risk factors of bone metastasis and the development of bone metastatic prognostic classification system: a pan-cancer population study

Zhouyang Hu, Sheng Yang, Zhipeng Xu, Xiaoling Zhang, Hong Wang, Guoxin Fan, Xiang Liao

https://doi.org/10.18632/aging.205224pp 13134—13149

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SEL1L3 as a link molecular between renal cell carcinoma and atherosclerosis based on bioinformatics analysis and experimental verification

Haoyuan Wang, Xiaopeng Ma, Sijie Li, Xiaochen Ni

https://doi.org/10.18632/aging.205227pp 13150—13162

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Hypoxia-regulated exosomes mediate M2 macrophage polarization and promote metastasis in chondrosarcoma

Sheng-Mou Hou, Chih-Yang Lin, Yi-Chin Fong, Chih-Hsin Tang

https://doi.org/10.18632/aging.205230pp 13163—13175

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Investigating EGF and PAG1 as necroptosis-related biomarkers for diabetic nephropathy: an in silico and in vitro validation study

Yuejun Wang, Linlin Zhang, Zhiping Peng

https://doi.org/10.18632/aging.205233pp 13176—13193

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Electroacupuncture ameliorates AOM/DSS-induced mice colorectal cancer by inhibiting inflammation and promoting autophagy via the SIRT1/miR-215/Atg14 axis

Jinxiao Li, Ying Han, Minfeng Zhou, Na Liu, Huarong Li, Guichen Huang, Zhaomin Yu, Dan Luo, Haiming Zhang, Xiangyi Zheng, Fengxia Liang, Rui Chen

https://doi.org/10.18632/aging.205236pp 13194—13212

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A prognostic risk model for programmed cell death and revealing TRIB3 as a promising apoptosis suppressor in renal cell carcinoma

Qingfeng Fu, Bocun Yi, Qiang Su, Yue Huang, Lin Wang, Zhihong Zhang

https://doi.org/10.18632/aging.205237pp 13213—13238

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Qi Fu Yin ameliorates neuroinflammation through inhibiting RAGE and TLR4/NF-κB pathway in AD model rats

Chunxiang He, Wenjing Yu, Miao Yang, Ze Li, Jingping Yu, Dayuan Zhong, Sisi Deng, Zhenyan Song, Shaowu Cheng

https://doi.org/10.18632/aging.205238pp 13239—13264

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Inhibiting KLRB1 expression is associated with impairing cancer immunity and leading to cancer progression and poor prognosis in breast invasive carcinoma patients

Jin-Rong He, Dan Li, Qun-Xian Zhang, Tao Liu, Yu Ding, Chuang-Yan Wu, Shan-Shan Chen, Jiu-Ling Chen

https://doi.org/10.18632/aging.205239pp 13265—13286

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Molecular characteristics and clinical implications of serine/arginine-rich splicing factors in human cancer

Jinjin Zhang, Zhicheng Fang, Congkuan Song

https://doi.org/10.18632/aging.205241pp 13287—13311

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Prognostic significance and immunoinfiltration analysis of genes associated with epithelial-mesenchymal transition and energy metabolism in bladder urothelial carcinoma

Yifan Qiu, Wei Ye, Chao Wang, Jin Zang

https://doi.org/10.18632/aging.205242pp 13312—13328

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circSLCO1B7 suppresses the malignant progression of hepatocellular carcinoma via the miR-556-3p/DAB2IP axis

Linling Ju, Qian Zhou, Qianyi Qi, Yongjun She, Weihua Cai, Yali Cao, Rujian Lu, Jianguo Shao, Lin Chen

https://doi.org/10.18632/aging.205244pp 13329—13344

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Immune microenvironment heterogeneity reveals distinct subtypes in neuroblastoma: insights into prognosis and therapeutic targets

Yanlan Yang, Huamei Li, Donghui Zheng, Xuemei Li, Hongyan Liu

https://doi.org/10.18632/aging.205246pp 13345—13367

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Comprehensive analysis of tertiary lymphoid structures-related genes for prognostic prediction, molecular subtypes and immune infiltration in gastric cancer

Qingde Zhou, Lan Lan, Wei Wang, Xinchang Xu, Wei Wang

https://doi.org/10.18632/aging.205247pp 13368—13383

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BDH1-mediated βOHB metabolism ameliorates diabetic kidney disease by activation of NRF2-mediated antioxidative pathway

Sheng-Rong Wan, Fang-Yuan Teng, Wei Fan, Bu-Tuo Xu, Xin-Yue Li, Xiao-Zhen Tan, Man Guo, Chen-Lin Gao, Chun-Xiang Zhang, Zong-Zhe Jiang, Yong Xu

https://doi.org/10.18632/aging.205248pp 13384—13410

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Regulatory mechanisms of miR-212-3p on the secretion of inflammatory factors in monocyte-macrophages and the directed differentiation into osteoclasts in ankylosing spondylitis

Jianli Xie, Jinrong Xu, Haiying Chen

https://doi.org/10.18632/aging.205249pp 13411—13421

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Effect of Nrf2 on brain injury induced by hydraulic shock via regulation of mitophagy and apoptosis

Erwei Zhang, Tongmao Wu, Yayu Zhuo, Junling Cui, Si Sun, Guobiao Wu, Gengshen Zhang

https://doi.org/10.18632/aging.205250pp 13422—13433

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Predicting the prognosis in patients with sepsis by an endoplasmic reticulum stress gene signature

Jian Liu, Hao Wang, Huimin Xiao, Li Ji, Yonghui Yao, Chunshui Cao, Yong Liu, Liang Huang

https://doi.org/10.18632/aging.205252pp 13434—13451

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Plumbagin alleviates temporomandibular joint osteoarthritis progression by inhibiting chondrocyte ferroptosis via the MAPK signaling pathways

Tiehan Cui, Yun Lan, Fei Yu, Suai Lin, Jiaxuan Qiu

https://doi.org/10.18632/aging.205253pp 13452—13470

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Enhanced serum levels of tumor necrosis factor-α, interleukin-1β, and -6 in sarcopenia: alleviation through exercise and nutrition intervention

Ke-Vin Chang, Wei-Ting Wu, Yu-Hsin Chen, Lan-Rong Chen, Wei-Hsiang Hsu, Yun-Lian Lin, Der-Sheng Han

https://doi.org/10.18632/aging.205254pp 13471—13485

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The ferroptosis landscape in acute myeloid leukemia

Zhixin Ma, Wenle Ye, Xin Huang, Xia Li, Fenglin Li, Xiangjie Lin, Chao Hu, Jinghan Wang, Jie Jin, Bo Zhu, Jiansong Huang

https://doi.org/10.18632/aging.205257pp 13486—13503

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Crosstalk between copper homeostasis and cuproptosis reveals a lncRNA signature to prognosis prediction, immunotherapy personalization, and agent selection for patients with lung adenocarcinoma

Chao Ma, Zhuoyu Gu, Weizheng Ding, Feng Li, Yang Yang

https://doi.org/10.18632/aging.205281pp 13504—13541

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Long non-coding RNA EGOT is associated with ¹³¹iodine sensitivity and contributes to thyroid cancer progression by targeting miR-641/PTEN axis

Ming Wang, Zhengchao Wei, Shuang Wang, Wenjuan Feng, Lihua Shang, Xiaosong Sun

https://doi.org/10.18632/aging.205284pp 13542—13557

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Lnc-PTCHD4-AS inhibits gastric cancer through MSH2-MSH6 dimerization and ATM-p53-p21 activation

Jingyun Wang, Yang Mi, Xiangdong Sun, Xia Xue, Huanjie Zhao, Mengfei Zhang, Baitong Hu, Ihtisham Bukhari, Pengyuan Zheng

https://doi.org/10.18632/aging.205329pp 13558—13578

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