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• Research PaperVolume 6, Issue 12pp 1064-1075

  Pathway activation profiling reveals new insights into Age-related Macular Degeneration and provides avenues for therapeutic interventions

  Relevance score: 0.00

  Evgeny Makarev, Charles Cantor, Alex Zhavoronkov, Anton Buzdin, Alexander Aliper, Antonei Benjamin Csoka

  Keywords: AMD, Age-related Macular Degeneration, gene expression, Transcriptome profiling, signaling pathway activation strength

  Published in Aging on December 22, 2014

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• Research PaperVolume 14, Issue 1pp 286-296

  Yes-associated protein reacts differently in vascular smooth muscle cells under different intensities of mechanical stretch

  Relevance score: 0.00

  Xinhao Wang, Xiangdang Liang, Lujun Zhou, Shen Liu, Zhuoqun Fang, Chuanzhong Hu, Yigong Hou, Zhanshe Guo

  Keywords: Hippo pathway, YAP, mechanical stretch, proliferation, apoptosis

  Published in Aging on January 4, 2022

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• Research PaperVolume 12, Issue 3pp 2169-2225

  Identification of 34 genes conferring genetic and pharmacological risk for the comorbidity of schizophrenia and smoking behaviors

  Relevance score: 0.00

  Yunlong Ma, Jingjing Li, Yi Xu, Yan Wang, Yinghao Yao, Qiang Liu, Maiqiu Wang, Xinyi Zhao, Rongli Fan, Jiali Chen, Bin Zhang, Zhen Cai, Haijun Han, Zhongli Yang, Wenji Yuan, Yigang Zhong, Xiangning Chen, Jennie Z. Ma, Thomas J. Payne, Yizhou Xu, Yuping Ning, Wenyan Cui, Ming D. Li

  Keywords: schizophrenia, tobacco smoking, multi-omics, susceptibility genes, pathways, GWAS

  Published in Aging on February 3, 2020

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• ReviewVolume 11, Issue 22pp 10742-10770

  Association of genes with phenotype in autism spectrum disorder

  Relevance score: 0.00

  Sabah Nisar, Sheema Hashem, Ajaz A. Bhat, Najeeb Syed, Santosh Yadav, Muhammad Waqar Azeem, Shahab Uddin, Puneet Bagga, Ravinder Reddy, Mohammad Haris

  Keywords: signaling pathways, genetic variants, neuronal activity, synaptic plasticity, gene transcription

  Published in Aging on November 19, 2019

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• Research PaperVolume 8, Issue 11pp 2936-2947

  Molecular pathway activation features of pediatric acute myeloid leukemia (AML) and acute lymphoblast leukemia (ALL) cells

  Relevance score: 0.00

  Ivan Petrov, Maria Suntsova, Olga Mutorova, Maxim Sorokin, Andrew Garazha, Elena Ilnitskaya, Pavel Spirin, Sergey Larin, Olga Kovalchuk, Vladimir Prassolov, Alex Zhavoronkov, Alexander Roumiantsev, Anton Buzdin

  Keywords: acute myeloid leukemia, acute lymphoblast leukemia, pediatric, adult, gene expression, intracellular signaling pathways, molecular markers, OncoFinder

  Published in Aging on November 19, 2016

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• Research PaperVolume 7, Issue 1pp 26-37

  Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells

  Relevance score: 0.00

  Alexander M. Aliper, Antonei Benjamin Csoka, Anton Buzdin, Tomasz Jetka, Sergey Roumiantsev, Alexey Moskalev, Alex Zhavoronkov

  Keywords: Progeria, HGPS, Lamin, LMNA, aging, aging pathway, pathway activation, pathway drift, geroscope, geroprotectors, senescence

  Published in Aging on January 9, 2015

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• Research PaperVolume 6, Issue 3pp 207-214

  Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca²⁺ response to glucose

  Relevance score: 0.00

  Kazuhiro Yanagida, Yuko Maejima, Putra Santoso, Zesemdorj Otgon-Uul, Yifei Yang, Kazuya Sakuma, Kenju Shimomura, Toshihiko Yada

  Keywords: Glucotoxicity, hexosamine pathway, insulin secretion

  Published in Aging on March 29, 2014

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• Research PaperVolume 4, Issue 10pp 715-722

  New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53^−/− mice by delaying carcinogenesis

  Relevance score: 0.00

  Maria Comas, Ilia Toshkov, Karen K. Kuropatwinski, Olga B. Chernova, Alexander Polinsky, Mikhail V. Blagosklonny, Andrei V. Gudkov, Marina P. Antoch

  Keywords: mTOR pathway, p53−/−, lifespan, rapamycin, oral formulation, cancer prevention

  Published in Aging on October 29, 2012

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• Research Paper

  Chronic stress promotes premature ovarian failure in mice by inhibiting ovarian granulosa cell autophagy through PI3K-AKTmTOR pathway

  Relevance score: 0.00

  Zhibin Zhao, Xuefei Yuan, Baohua Zhao, Kai He

  Keywords: PI3K-AKT-mTOR pathway, premature ovarian failure (POF), ovarian granulosa cells (OGCs), chronic stress

  Published in Aging on October 8, 2024

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• Research PaperVolume 16, Issue 2pp 1516-1535

  Molecular map of cGAS-STING pathway-related genes in bladder cancer: the perspective toward immune microenvironment and prognosis

  Relevance score: 0.00

  Dong Wei, Ying Liu, Ying Yuan, Yishuai Li, Fangchao Zhao, Xuebo Qin

  Keywords: cGAS-STING pathway, bladder cancer, tumor immune, immune microenvironment, immune checkpoint inhibitors

  Published in Aging on January 17, 2024

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• Research PaperVolume 15, Issue 12pp 5426-5444

  Chaetocin exhibits anticancer effects in esophageal squamous cell carcinoma via activation of Hippo pathway

  Relevance score: 0.00

  Lin Li, Hangyu Jiang, Yuqi Li, Xiaochong Xiang, Yueming Chu, Jie Tang, Kang Liu, Danqun Huo, Xiaofen Zhang

  Keywords: esophageal squamous cell carcinoma, chaetocin, ROS, Hippo pathway, apoptosis

  Published in Aging on June 14, 2023

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• Research PaperVolume 15, Issue 4pp 1210-1227

  Inhibition of apoptosis through AKT-mTOR pathway in ovarian cancer and renal cancer

  Relevance score: 0.00

  Hongrun Chen, Lianfeng Zhang, Meini Zuo, Xiaowen Lou, Bin Liu, Taozhu Fu

  Keywords: Akt-mTOR pathway, renal cancer, ovarian cancer, bioinformatics, verification, biomarker

  Published in Aging on February 27, 2023

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• Research PaperVolume 15, Issue 9pp 3381-3393

  PI3K-Akt signaling pathway based on network pharmacology for the anti-Alzheimer’s disease effect of licorice stem flavonoids

  Relevance score: 0.00

  Hongyan Pei, Lei He, Meiling Shi, Xiangjuan Guo, Weijia Chen, Jianming Li, Zhongmei He, Rui Du

  Keywords: network pharmacology, Alzheimer’s disease, licorice stem flavonoids, PI3K-Akt signalling pathway

  Published in Aging on February 22, 2023

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• Research PaperVolume 14, Issue 12pp 5250-5270

  TRPM7 via calcineurin/NFAT pathway mediates metastasis and chemotherapeutic resistance in head and neck squamous cell carcinoma

  Relevance score: 0.00

  Tsung-Ming Chen, Chih-Ming Huang, Ming-Shou Hsieh, Chun-Shu Lin, Wei-Hwa Lee, Chi-Tai Yeh, Shao-Cheng Liu

  Keywords: HNSCC, transient receptor potential cation channel subfamily M member 7, chemoresistance, calcineurin/NFAT pathway, cancer stem cell

  Published in Aging on June 29, 2022

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• Research PaperVolume 13, Issue 18pp 22474-22489

  Identification of genes and pathways leading to metastasis and poor prognosis in melanoma

  Relevance score: 0.00

  Xin Zhang, Wandong Wang, Yun Wang, Guan Jiang

  Keywords: melanoma, bioinformatics, signaling pathway, survival analysis, regulatory analysis

  Published in Aging on September 28, 2021

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• Research PaperVolume 13, Issue 1pp 1096-1119

  The endothelial nitric oxide synthase/cyclic guanosine monophosphate/protein kinase G pathway activates primordial follicles

  Relevance score: 0.00

  Peikun Zhao, Zidai Song, Yan Wang, Han Cai, Xiaoyan Du, Changlong Li, Jianyi Lv, Xin Liu, Meng Guo, Zhenwen Chen

  Keywords: eNOS/cGMP/PKG pathway, mTOR, FBXW7, primordial follicle activation, ubiquitination

  Published in Aging on December 3, 2020

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• Research PaperVolume 12, Issue 22pp 22840-22858

  Establishing and validating a pathway prognostic signature in pancreatic cancer based on miRNA and mRNA sets using GSVA

  Relevance score: 0.00

  Junfeng Zhang, Jianyou Gu, Shixiang Guo, Wenjie Huang, Yao Zheng, Xianxing Wang, Tao Zhang, Weibo Zhao, Bing Ni, Yingfang Fan, Huaizhi Wang

  Keywords: pancreatic cancer, prognostic signature, miRNA sets, GSVA, metabolic pathways

  Published in Aging on November 10, 2020

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• Research PaperVolume 12, Issue 10pp 9311-9327

  Single nucleotide polymorphisms within the Wnt pathway predict the risk of bone metastasis in patients with non-small cell lung cancer

  Relevance score: 0.00

  Yiquan Xu, Hongru Li, Lihong Weng, Yanqin Qiu, Junqiong Zheng, Huaqiang He, Dongmei Zheng, Junfan Pan, Fan Wu, Yusheng Chen

  Keywords: Wnt signaling pathway, polymorphisms, bone metastasis, risk, biomarker

  Published in Aging on May 26, 2020

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• Research PaperVolume 12, Issue 3pp 2246-2260

  The protein tyrosine kinase inhibitor, Genistein, delays intervertebral disc degeneration in rats by inhibiting the p38 pathway-mediated inflammatory response

  Relevance score: 0.00

  Jun Ge, Quan Zhou, Xiaoqiang Cheng, Jiale Qian, Qi Yan, Cenhao Wu, Yufeng Chen, Huilin Yang, Jun Zou

  Keywords: p38 MAPK pathway, intervertebral disc degeneration, Genistein, phosphorylation

  Published in Aging on February 5, 2020

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• EditorialVolume 11, Issue 4pp 1085-1086

  Aortic stenosis: what is the role of aging processes?

  Relevance score: 0.00

  Nancy Côté, Philippe Pibarot, Marie-Annick Clavel

  Keywords: aortic stenosis, pathophysiology, aging, calcification, pathways

  Published in Aging on February 11, 2019