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• Research PerspectiveVolume 15, Issue 14pp 6632-6640

  Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?

  Relevance score: 0.00

  Mikhail V. Blagosklonny

  Keywords: mTOR, hyperfunction, lifespan, health span, cancer, Alzheimer’s disease

  Published in Aging on July 20, 2023

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• Research PerspectiveVolume 13, Issue 3pp 3167-3175

  DNA- and telomere-damage does not limit lifespan: evidence from rapamycin

  Relevance score: 0.00

  Mikhail V. Blagosklonny

  Keywords: quasi-programmed aging, hyperfunction theory, antagonistic pleiotropy, natural selection, mTOR

  Published in Aging on February 12, 2021

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• EssayVolume 17, Issue 11pp 2655-2663

  On the intergenerational transfer of ideas in aging and cancer research: from the hypothalamus according to V.M. Dilman to the mTOR protein complex according to M.V. Blagosklonny

  Relevance score: 0.00

  Aleksei G. Golubev

  Keywords: gerontology, history of science, hyperfunction, mTOR, hypothalamus, cancer, metabolism, immunity

  Published in Aging on November 19, 2025

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• ReviewVolume 15, Issue 4pp 905-913

  Cellular senescence: when growth stimulation meets cell cycle arrest

  Relevance score: 0.00

  Mikhail V. Blagosklonny

  Keywords: rapamycin, mTOR, hyperfunction theory of aging, cell volume and enlargement, gerogenic conversion

  Published in Aging on February 19, 2023

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• Research PerspectiveVolume 15, Issue 2pp 298-307

  Are menopause, aging and prostate cancer diseases?

  Relevance score: 0.00

  Mikhail V. Blagosklonny

  Keywords: geroscience, mTOR, hyperfunction theory of aging, lifespan, healthspan

  Published in Aging on January 26, 2023

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• ReviewVolume 17, Issue 12pp 2989-3002

  Aging as a multifactorial disorder with two stages

  Relevance score: 0.00

  David Gems, Alexander Carver, Yuan Zhao

  Keywords: aging, C. elegans, disease, hyperfunction, multifactorial model

  Published in Aging on December 30, 2025

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• Priority ReviewVolume 17, Issue 1pp 1-15

  Mikhail ‘Misha’ Blagosklonny’s enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin

  Relevance score: 0.00

  David A. Barzilai

  Keywords: rapamycin, longevity medicine, healthspan, geroscience, hyperfunction

  Published in Aging on January 12, 2025

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• ReviewVolume 14, Issue 9pp 4176-4187

  Hallmarks of cancer and hallmarks of aging

  Relevance score: 0.00

  Mikhail V. Blagosklonny

  Keywords: oncology, carcinogenesis, geroscience, mTOR, rapamycin, hyperfunction theory

  Published in Aging on May 9, 2022

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