Research Perspective|Volume 13, Issue 3|pp 3167—3175

DNA- and telomere-damage does not limit lifespan: evidence from rapamycin

Mikhail V. Blagosklonny¹

¹Roswell Park Cancer Institute, Buffalo, NY 14263, USA

Received: January 29, 2021Accepted: February 10, 2021Published: February 12, 2021

https://doi.org/10.18632/aging.202674

Copyright: © 2021 Blagosklonny. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Failure of rapamycin to extend lifespan in DNA repair mutant and telomerase-knockout mice, while extending lifespan in normal mice, indicates that neither DNA damage nor telomere shortening limits normal lifespan or causes normal aging.