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• Research PaperVolume 11, Issue 24pp 11922-11936

  Suppression of protein degradation by leucine requires its conversion to β-hydroxy-β-methyl butyrate in C2C12 myotubes

  Relevance score: 0.00

  Yehui Duan, Yinzhao Zhong, Bo Song, Changbing Zheng, Kang Xu, Xiangfeng Kong, Fengna Li

  Keywords: β-hydroxy-β-methyl butyrate, protein degradation, mitochondrial function, leucine, C2C12 myotubes

  Published in Aging on December 24, 2019

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• Research PaperVolume 16, Issue 1pp 685-700

  ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis

  Relevance score: 0.00

  Mingkui Shen, Kuankuan Li, Lulu Wang, Li Feng, Xinyu Zhang, Haoping Zhang, Honggang Zhou, Guoxian Pei

  Keywords: ZIP4, nucleus pulposus cells, extracellular matrix degradation, HDAC4, FoxO3a

  Published in Aging on January 12, 2024

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• Research PaperVolume 13, Issue 13pp 17690-17706

  α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice

  Relevance score: 0.00

  Huawei Zhang, Sunlong Li, Jiajie Lu, Jie Jin, Gaosheng Zhu, Libo Wang, Yingzhao Yan, Linjie He, Ben Wang, Xiangyang Wang, Huachen Yu

  Keywords: α-Cyperone, osteoarthritis, inflammation, extracellular matrix degradation

  Published in Aging on July 8, 2021

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• Research PaperVolume 13, Issue 10pp 14185-14197

  Circular RNA ITCH promotes extracellular matrix degradation via activating Wnt/β-catenin signaling in intervertebral disc degeneration

  Relevance score: 0.00

  Feng Zhang, Feili Lin, Zhiwen Xu, Zheng Huang

  Keywords: intervertebral disc degeneration, extracellular matrix ECM degradation, circITCH, miR-17-5p, SOX4

  Published in Aging on May 18, 2021

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• Research PaperVolume 3, Issue 1pp 33-43

  HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation

  Relevance score: 0.00

  Lavinia Nardinocchi, Rosa Puca, Gabriella D'Orazi

  Keywords: HIF-1α, HIPK2, zinc, proteasomal degradation, p53 transcriptional activity, p53Ser46

  Published in Aging on January 18, 2011

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• Research PaperVolume 2, Issue 12pp 959-968

  Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells

  Relevance score: 0.00

  Yiping Huang, Edward A. Ratovitski

  Keywords: p63, LKB1, oncogene, tumor suppressor, protein degradation, autophagy, chemoresistance

  Published in Aging on December 20, 2010

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• Research PaperVolume 12, Issue 1pp 481-501

  A novel rhamnoside derivative PL402 up-regulates matrix metalloproteinase 3/9 to promote Aβ degradation and alleviates Alzheimer’s-like pathology

  Relevance score: 0.00

  Tingting Hu, Yue Zhou, Jing Lu, Peng Xia, Yue Chen, Xin Cao, Gang Pei

  Keywords: Alzheimer’s disease, Aβ degradation, matrix metalloproteinase 3/9, learning and memory deficits, natural products derivate

  Published in Aging on January 5, 2020

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• Research PaperVolume 13, Issue 1pp 1176-1185

  The 1316T>C missenses mutation in MTHFR contributes to MTHFR deficiency by targeting MTHFR to proteasome degradation

  Relevance score: 0.00

  Xi Liu, Yu Li, Menghan Wang, Xiaojun Wang, Limin Zhang, Tao Peng, Wenping Liang, Zhe Wang, Hong Lu

  Keywords: molecular mechanisms, MTHFR deficiency, proteasome degradation, pathogenic mutation, single nucleotide polymophorism

  Published in Aging on December 3, 2020

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• Research PaperVolume 12, Issue 22pp 22892-22905

  USP10 deletion inhibits macrophage-derived foam cell formation and cellular-oxidized low density lipoprotein uptake by promoting the degradation of CD36

  Relevance score: 0.00

  Xiaohong Xia, Tumei Hu, Jinchan He, Qiong Xu, Cuifu Yu, Xiaolin Liu, Zhenlong Shao, Yuning Liao, Hongbiao Huang, Ningning Liu

  Keywords: atherosclerosis, foam cell, CD36, USP10, degradation

  Published in Aging on November 10, 2020

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• Research PaperVolume 13, Issue 24pp 25670-25693

  Chronobiological activity of cysteinyl leukotriene receptor 1 during basal and induced autophagy in the ARPE-19 retinal pigment epithelial cell line

  Relevance score: 0.00

  Andreas Koller, Julia Preishuber-Pflügl, Christian Runge, Anja-Maria Ladek, Susanne Maria Brunner, Ludwig Aigner, Herbert Reitsamer, Andrea Trost

  Keywords: autophagy, CysLTR1, LC3B, lysosomal degradation, retinal pigment epithelial cells

  Published in Aging on December 17, 2021

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• Research PaperVolume 11, Issue 16pp 6134-6152

  Beta-amyloid induces apoptosis of neuronal cells by inhibition of the Arg/N-end rule pathway proteolytic activity

  Relevance score: 0.00

  Olga I. Kechko, Irina Yu. Petrushanko, Christopher S. Brower, Alexei A. Adzhubei, Alexey A. Moskalev, Konstantin I. Piatkov, Vladimir A. Mitkevich, Alexander A. Makarov

  Keywords: age-related disease, Alzheimer’s disease, apoptosis, Ate1, protein degradation

  Published in Aging on August 24, 2019

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• Research PaperVolume 8, Issue 5pp 873-887

  Mutual inhibition of insulin signaling and PHLPP-1 determines cardioprotective efficiency of Akt in aged heart

  Relevance score: 0.00

  Yuan Xing, Wanqing Sun, Yishi Wang, Feng Gao, Heng Ma

  Keywords: myocardial I/R, insulin, PHLPP-1, Akt, degradation

  Published in Aging on March 27, 2016

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