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The cover features Figure 14 "Wild-type mouse lenses in the B6 genetic background showed increased volume, nucleus size and overall stiffness, changes in cell morphology and microstructure along with appearance of anterior, cortical and ring cataracts with age. “ from Cheng et al.

Volume 11, Issue 24

31 December, 2019
pp 11795—26200

About the Cover

The cover features Figure 14 "Wild-type mouse lenses in the B6 genetic background showed increased volume, nucleus size and overall stiffness, changes in cell morphology and microstructure along with appearance of anterior, cortical and ring cataracts with age. “ from Cheng et al.


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Editorials

The impact of age on long QT syndrome

Norbert Guettler, Kim Rajappan, Edward Nicol,
https://doi.org/10.18632/aging.102623 pp 11795—11796
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Public reporting of PCI operator outcomes

Matthew D. Kelham, Andrew Wragg, Daniel A. Jones,
https://doi.org/10.18632/aging.102624 pp 11797—11798
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MicroRNA-34a and vascular senescence in diabetes

Menaka C. Thounaojam, Manuela Bartoli,
https://doi.org/10.18632/aging.102625 pp 11799—11800
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New treatments for progeria

Ricardo Villa-Bellosta,
https://doi.org/10.18632/aging.102626 pp 11801—11802
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Research Papers

LncRNA HIF1A-AS2 promotes osteosarcoma progression by acting as a sponge of miR-129-5p

Xuesong Wang, Lei Peng, Xiaojin Gong, Xiugong Zhang, Ruifu Sun,
https://doi.org/10.18632/aging.102448 pp 11803—11813
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Circadian clock associates with tumor microenvironment in thoracic cancers

Yong Yang, Guangda Yuan, Hongya Xie, Tengteng Wei, Donglin Zhu, Jianyong Cui, Xiaoqiang Liu, Rongming Shen, Yimeng Zhu, Xuefang Yang,
https://doi.org/10.18632/aging.102450 pp 11814—11828
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Suppression of FADS1 induces ROS generation, cell cycle arrest, and apoptosis in melanocytes: implications for vitiligo

Luyan Tang, Jian Li, Wenwen Fu, Wenyu Wu, Jinhua Xu,
https://doi.org/10.18632/aging.102452 pp 11829—11843
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Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1

Ruijuan Guan, Zhou Cai, Jian Wang, Mingjing Ding, Ziying Li, Jingyi Xu, Yuanyuan Li, Jingpei Li, Hongwei Yao, Wei Liu, Jing Qian, Bingxian Deng, Chun Tang, Dejun Sun, Wenju Lu,
https://doi.org/10.18632/aging.102454 pp 11844—11864
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MicroRNA 27b promotes cardiac fibrosis by targeting the FBW7/Snail pathway

Qiang Fu, Zhihong Lu, Xiao Fu, Shitang Ma, Xiaochun Lu,
https://doi.org/10.18632/aging.102465 pp 11865—11879
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Molecular subtypes based on DNA methylation predict prognosis in colon adenocarcinoma patients

Changshun Yang, Yu Zhang, Xiaoqin Xu, Weihua Li,
https://doi.org/10.18632/aging.102492 pp 11880—11892
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FLT3L and granulocyte macrophage colony-stimulating factor enhance the anti-tumor and immune effects of an HPV16 E6/E7 vaccine

Zhenzhen Ding, Hua Zhu, Laiming Mo, Xiangyun Li, Rui Xu, Tian Li, Liang Zhao, Yi Ren, Yunsheng Xu, Rongying Ou,
https://doi.org/10.18632/aging.102494 pp 11893—11904
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KIF20A promotes cellular malignant behavior and enhances resistance to chemotherapy in colorectal cancer through regulation of the JAK/STAT3 signaling pathway

Man Xiong, Kangmin Zhuang, Yunchen Luo, Qiuhua Lai, Xiaobei Luo, Yuxin Fang, Yue Zhang, Aimin Li, Side Liu,
https://doi.org/10.18632/aging.102505 pp 11905—11921
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Suppression of protein degradation by leucine requires its conversion to β-hydroxy-β-methyl butyrate in C2C12 myotubes

Yehui Duan, Yinzhao Zhong, Bo Song, Changbing Zheng, Kang Xu, Xiangfeng Kong, Fengna Li,
https://doi.org/10.18632/aging.102509 pp 11922—11936
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Hsa_circ_0006948 enhances cancer progression and epithelial-mesenchymal transition through the miR-490-3p/HMGA2 axis in esophageal squamous cell carcinoma

Zihao Pan, Jiatong Lin, Duoguang Wu, Xiaotian He, Wenjian Wang, Xueting Hu, Lei Zhang, Minghui Wang,
https://doi.org/10.18632/aging.102519 pp 11937—11954
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Platelet-derived β2m regulates age related monocyte/macrophage functions

Zachary T. Hilt, Sara K. Ture, Amy Mohan, Allison Arne, Craig N. Morrell,
https://doi.org/10.18632/aging.102520 pp 11955—11974
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Epigenetic mortality predictors and incidence of breast cancer

Jacob K. Kresovich, Zongli Xu, Katie M. O’Brien, Clarice R. Weinberg, Dale P. Sandler, Jack A. Taylor,
https://doi.org/10.18632/aging.102523 pp 11975—11987
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CircRNA AFF4 promotes osteoblast cells proliferation and inhibits apoptosis via the Mir-7223-5p/PIK3R1 axis

Bobin Mi, Yuan Xiong, Lang Chen, Chenchen Yan, Yori Endo, Yi Liu, Jing Liu, Liangcong Hu, Yiqiang Hu, Yun Sun, Faqi Cao, Wu Zhou, Guohui Liu,
https://doi.org/10.18632/aging.102524 pp 11988—12001
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Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice

Chen Diling, Guo Yinrui, Qi Longkai, Tang Xiaocui, Liu Yadi, Yang Xin, Hu Guoyan, Shuai Ou, Yong Tianqiao, Wang Dongdong, Xie Yizhen, Burton B. Yang, Wu Qingping,
https://doi.org/10.18632/aging.102529 pp 12002—12031
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Compound 13 activates AMPK-Nrf2 signaling to protect neuronal cells from oxygen glucose deprivation-reoxygenation

Yanqing Mo, Jian-liang Zhu, Aihua Jiang, Jing Zhao, Liping Ye, Bin Han,
https://doi.org/10.18632/aging.102534 pp 12032—12042
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CircAHNAK1 inhibits proliferation and metastasis of triple-negative breast cancer by modulating miR-421 and RASA1

Weikai Xiao, Shaoquan Zheng, Yutian Zou, Anli Yang, Xinhua Xie, Hailin Tang, Xiaoming Xie,
https://doi.org/10.18632/aging.102539 pp 12043—12056
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Screening, identification and validation of CCND1 and PECAM1/CD31 for predicting prognosis in renal cell carcinoma patients

Jian-Feng Yang, Shen-Nan Shi, Wen-Hao Xu, Yun-Hua Qiu, Jin-Zhou Zheng, Kui Yu, Xiao-Yun Song, Feng Li, Yu Wang, Rui Wang, Yuan-Yuan Qu, Hai-Liang Zhang, Xi-Qiu Zhou,
https://doi.org/10.18632/aging.102540 pp 12057—12079
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Age-related changes in microbial composition and function in cynomolgus macaques

Jiajia Duan, Bangmin Yin, Wei Li, Tingjia Chai, Weiwei Liang, Yu Huang, Xunmin Tan, Peng Zheng, Jing Wu, Yifan Li, Yan Li, Wei Zhou, Peng Xie,
https://doi.org/10.18632/aging.102541 pp 12080—12096
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Aerosol inhalation of a hydrogen-rich solution restored septic renal function

Weifeng Yao, Anshun Guo, Xue Han, Shan Wu, Chaojin Chen, Chenfang Luo, Haobo Li, Shangrong Li, Ziqing Hei,
https://doi.org/10.18632/aging.102542 pp 12097—12113
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Reduced miR-203 predicts metastasis and poor survival in esophageal carcinoma

Rongqi He, Jintian Wang, Kai Ye, Jiabin Du, Junxing Chen, Weinan Liu,
https://doi.org/10.18632/aging.102543 pp 12114—12130
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Identification of breast cancer risk modules via an integrated strategy

Wan Li, Gui Deng, Ji Zhang, Erqiang Hu, Yuehan He, Junjie Lv, Xilin Sun, Kai Wang, Lina Chen,
https://doi.org/10.18632/aging.102546 pp 12131—12146
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Hematoma-derived exosomes of chronic subdural hematoma promote abnormal angiogenesis and inhibit hematoma absorption through miR-144-5p

Chuang Gao, Zhitao Gong, Dong Wang, Jinhao Huang, Yu Qian, Meng Nie, Weiwei Jiang, Xuanhui Liu, Hongliang Luo, Jiangyuan Yuan, Tangtang Xiang, Shuo An, Wei Quan, Huijie Wei, Jianning Zhang, Rongcai Jiang,
https://doi.org/10.18632/aging.102550 pp 12147—12164
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GPX1, a biomarker for the diagnosis and prognosis of kidney cancer, promotes the progression of kidney cancer

Yongbiao Cheng, Tianbo Xu, Sen Li, Hailong Ruan,
https://doi.org/10.18632/aging.102555 pp 12165—12176
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Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress

Shi Zilu, Huang Qian, Wu Haibin, Ge Chenxu, Lou Deshuai, Li Qiang, Hu Linfeng, Tan Jun, Xu Minxuan,
https://doi.org/10.18632/aging.102559 pp 12177—12201
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Cerebrospinal fluid and blood Aβ levels in Down syndrome patients with and without dementia: a meta-analysis study

Yang Du, Lei Chen, Yuguo Jiao, Yong Cheng,
https://doi.org/10.18632/aging.102560 pp 12202—12212
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Targeting CARD6 attenuates spinal cord injury (SCI) in mice through inhibiting apoptosis, inflammation and oxidative stress associated ROS production

Jiang Lin Wang, Xiao Luo, Li Liu,
https://doi.org/10.18632/aging.102561 pp 12213—12235
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Improved therapeutic effects on diabetic foot by human mesenchymal stem cells expressing MALAT1 as a sponge for microRNA-205-5p

Lingyan Zhu, Qiaoqing Zhong, Tianlun Yang, Xiangwei Xiao,
https://doi.org/10.18632/aging.102562 pp 12236—12245
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Development and validation of a nomogram with an autophagy-related gene signature for predicting survival in patients with glioblastoma

Zihao Wang, Lu Gao, Xiaopeng Guo, Chenzhe Feng, Wei Lian, Kan Deng, Bing Xing,
https://doi.org/10.18632/aging.102566 pp 12246—12269
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Relationship between PD-L1 expression and 18F-FDG uptake in gastric cancer

Ruohua Chen, Yumei Chen, Gang Huang, Jianjun Liu,
https://doi.org/10.18632/aging.102567 pp 12270—12277
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Insulin-like growth factor-1 enhances neuroprotective effects of neural stem cell exosomes after spinal cord injury via an miR-219a-2-3p/YY1 mechanism

Ke Ma, Huiyou Xu, Jian Zhang, Fei Zhao, Haiqian Liang, Hongtao Sun, Ping Li, Sai Zhang, Renjie Wang, Xuyi Chen,
https://doi.org/10.18632/aging.102568 pp 12278—12294
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ERK1 indicates good prognosis and inhibits breast cancer progression by suppressing YAP1 signaling

Shiyi Yu, Meng Zhang, Ling Huang, Zhifang Ma, Xue Gong, Weiguang Liu, Jun Zhang, Liming Chen, Zhenghong Yu, Weiyong Zhao, Yan Liu,
https://doi.org/10.18632/aging.102572 pp 12295—12314
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β-arrestin2 alleviates L-dopa–induced dyskinesia via lower D1R activity in Parkinson’s rats

Xing-Ru Zhang, Zeng-Rui Zhang, Si-Yan Chen, Wen-Wen Wang, Xin-Shi Wang, Jin-Cai He, Cheng-Long Xie,
https://doi.org/10.18632/aging.102574 pp 12315—12327
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Overexpressed methyltransferase-like 1 (METTL1) increased chemosensitivity of colon cancer cells to cisplatin by regulating miR-149-3p/S100A4/p53 axis

Yang Liu, Chunyan Yang, Yong Zhao, Qiang Chi, Zhen Wang, Boshi Sun,
https://doi.org/10.18632/aging.102575 pp 12328—12344
View Abstract PDF Full-Text How to Cite Special Collection on p53 Part 2

Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO

Zhiyong Xiong, Chaoyang Zhou, Luyang Wang, Ronglan Zhu, Liangchen Zhong, Dengfeng Wan, Qiangping Wang,
https://doi.org/10.18632/aging.102576 pp 12345—12360
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A phenolic amide (LyA) isolated from the fruits of Lycium barbarum protects against cerebral ischemia–reperfusion injury via PKCε/Nrf2/HO-1 pathway

Kai Gao, Meiyou Liu, Yi Ding, Minna Yao, Yanrong Zhu, Jinyi Zhao, Lianghua Cheng, Juan Bai, Fan Wang, Jinyi Cao, Jiankang Li, Haifeng Tang, Yanyan Jia, Aidong Wen,
https://doi.org/10.18632/aging.102578 pp 12361—12374
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Discovering master regulators in hepatocellular carcinoma: one novel MR, SEC14L2 inhibits cancer cells

Zhihui Li, Yi Lou, Guoyan Tian, Jianyue Wu, Anqian Lu, Jin Chen, Beibei Xu, Junping Shi, Jin Yang,
https://doi.org/10.18632/aging.102579 pp 12375—12411
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CircRNA_100367 regulated the radiation sensitivity of esophageal squamous cell carcinomas through miR-217/Wnt3 pathway

Junqi Liu, Nannan Xue, Yuexin Guo, Kerun Niu, Liang Gao, Song Zhang, Hao Gu, Xin Wang, Di Zhao, Ruitai Fan,
https://doi.org/10.18632/aging.102580 pp 12412—12427
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System level characterization of small molecule drugs and their affected long noncoding RNAs

Haixiu Yang, Yanan Jiang, Yunpeng Zhang, Yanjun Xu, Chunlong Zhang, Junwei Han, Fei Su, Xiaoqi Liu, Kai Mi, Bing Liu, Desi Shang,
https://doi.org/10.18632/aging.102581 pp 12428—12451
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Mitochondrial metabolic study guided by proteomics analysis in hepatocellular carcinoma cells surviving long-term incubation with the highest dose of sorafenib

Jing Bai, Ziqi Liu, Jiang Liu, Saihang Zhang, Yuan Tian, Yueshan Zhang, Leiming Ren, Dezhi Kong,
https://doi.org/10.18632/aging.102582 pp 12452—12475
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lncRNA Rmst acts as an important mediator of BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) by antagonizing Notch-targeting microRNAs

Zhicai Zhang, Jianxiang Liu, Zongyue Zeng, Jiaming Fan, Shifeng Huang, Linghuan Zhang, Bo Zhang, Xi Wang, Yixiao Feng, Zhenyu Ye, Ling Zhao, Daigui Cao, Lijuan Yang, Mikhail Pakvasa, Bin Liu, William Wagstaff, Xiaoxing Wu, Huaxiu Luo, Jing Zhang, Meng Zhang, Fang He, Yukun Mao, Huimin Ding, Yongtao Zhang, Changchun Niu, Rex C. Haydon, Hue H. Luu, Michael J. Lee, Jennifer Moriatis Wolf, Zengwu Shao, Tong-Chuan He,
https://doi.org/10.18632/aging.102583 pp 12476—12496
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Age-related changes in eye lens biomechanics, morphology, refractive index and transparency

Catherine Cheng, Justin Parreno, Roberta B. Nowak, Sondip K. Biswas, Kehao Wang, Masato Hoshino, Kentaro Uesugi, Naoto Yagi, Juliet A. Moncaster, Woo-Kuen Lo, Barbara Pierscionek, Velia M. Fowler,
https://doi.org/10.18632/aging.102584 pp 12497—12531
View Abstract PDF Full-Text How to Cite Special Collection on Eye Disease

Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis

Xiaojian Huang, Bowei Ni, Yang Xi, Xiangyu Chu, Rui Zhang, Hongbo You,
https://doi.org/10.18632/aging.102586 pp 12532—12545
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Sirt1-inducible deacetylation of p21 promotes cardiomyocyte proliferation

Bing Li, Mengsha Li, Xinzhong Li, Hairui Li, Yanxian Lai, Senlin Huang, Xiang He, Xiaoyun Si, Hao Zheng, Wangjun Liao, Yulin Liao, Jianping Bin,
https://doi.org/10.18632/aging.102587 pp 12546—12567
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Prognostic role of programmed death-ligand 1 expression in patients with biliary tract cancer: a meta-analysis

Changjiang Lei, Xiulan Peng, Xiaojun Gong, Ying Fan, Shenglin Wu, Ning Liu, Lei Li, Jianbin Huang, Gang Zheng, Zhixiong Long,
https://doi.org/10.18632/aging.102588 pp 12568—12580
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FOXP3 pathogenic variants cause male infertility through affecting the proliferation and apoptosis of human spermatogonial stem cells

Qianqian Qiu, Xing Yu, Chencheng Yao, Yujun Hao, Liqing Fan, Chunyi Li, Peng Xu, Geng An, Zheng Li, Zuping He,
https://doi.org/10.18632/aging.102589 pp 12581—12599
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Genome-wide global identification of NRF2 binding sites in A549 non-small cell lung cancer cells by ChIP-Seq reveals NRF2 regulation of genes involved in focal adhesion pathways

Akhileshwar Namani, Kaihua Liu, Shengcun Wang, Xihang Zhou, Yijiao Liao, Hongyan Wang, Xiu Jun Wang, Xiuwen Tang,
https://doi.org/10.18632/aging.102590 pp 12600—12623
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Long noncoding RNA NNT-AS1 enhances the malignant phenotype of bladder cancer by acting as a competing endogenous RNA on microRNA-496 thereby increasing HMGB1 expression

Deyao Wu, Tielong Zhang, Jie Wang, Jian Zhou, Huixing Pan, Ping Qu,
https://doi.org/10.18632/aging.102591 pp 12624—12640
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Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair

Yuelin Zhang, Wenwu Zhu, Haiwei He, Baohan Fan, Rui Deng, Yimei Hong, Xiaoting Liang, Hongyan Zhao, Xin Li, Fengxiang Zhang,
https://doi.org/10.18632/aging.102592 pp 12641—12660
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Targeting cyclophilin-D by miR-1281 protects human macrophages from Mycobacterium tuberculosis-induced programmed necrosis and apoptosis

Qin Sun, Xiaona Shen, Peng Wang, Jun Ma, Wei Sha,
https://doi.org/10.18632/aging.102593 pp 12661—12673
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Exposure to secondhand tobacco smoke is associated with reduced muscle strength in US adults

Monica Carrasco-Rios, Rosario Ortolá, Fernando Rodríguez-Artalejo, Esther García-Esquinas,
https://doi.org/10.18632/aging.102594 pp 12674—12684
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Combination of lymphocyte number and function in evaluating host immunity

Ying Luo, Yalong Xie, Weijie Zhang, Qun Lin, Guoxing Tang, Shiji Wu, Min Huang, Botao Yin, Jin Huang, Wei Wei, Jing Yu, Hongyan Hou, Liyan Mao, Weiyong Liu, Feng Wang, Ziyong Sun,
https://doi.org/10.18632/aging.102595 pp 12685—12707
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Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies

Dingli Song, Yujiao Deng, Kang Liu, Linghui Zhou, Na Li, Yi Zheng, Qian Hao, Si Yang, Ying Wu, Zhen Zhai, Hongtao Li, Zhijun Dai,
https://doi.org/10.18632/aging.102597 pp 12708—12732
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The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling

Zhu Zhu, Wu Yichen, Zhang Ziheng, Ge Dinghao, Lu Ming, Liu Wei, Shan Enfang, Hu Gang, Hiroaki Honda, Yang Jian,
https://doi.org/10.18632/aging.102599 pp 12733—12753
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Expression profile-based screening for critical genes reveals S100A4, ACKR3 and CDH1 in docetaxel-resistant prostate cancer cells

Sha Zhu, Zhixue Min, Xianli Qiao, Shengxian Chen, Jian Yang, Xiao Zhang, Xigang Liu, Weijie Ran, Renguang Lv, Ying Lin, Jin Wang,
https://doi.org/10.18632/aging.102600 pp 12754—12772
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KIFC1 is essential for normal spermatogenesis and its depletion results in early germ cell apoptosis in the Kuruma shrimp, Penaeus (Marsupenaeus) japonicus

Shuang-Li Hao, Wan-Xi Yang,
https://doi.org/10.18632/aging.102601 pp 12773—12792
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Loss of Klotho contributes to cartilage damage by derepression of canonical Wnt/β-catenin signaling in osteoarthritis mice

Yanqing Gu, Kewei Ren, Liming Wang, Qingqiang Yao,
https://doi.org/10.18632/aging.102603 pp 12793—12809
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Nicotine instigates podocyte injury via NLRP3 inflammasomes activation

Gurinder Bir Singh, Naresh Kshirasagar, Sai Patibandla, Goverdhan Puchchakayala, Saisudha Koka, Krishna M. Boini,
https://doi.org/10.18632/aging.102611 pp 12810—12821
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Commentary

Rapamycin for the aging skin

Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.102664 pp 12822—12826
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Reviews

Tau as a potential therapeutic target for ischemic stroke

Xin Chen, Hua Jiang,
https://doi.org/10.18632/aging.102547 pp 12827—12843
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Targeting senescent cells: approaches, opportunities, challenges

Cayetano von Kobbe,
https://doi.org/10.18632/aging.102557 pp 12844—12861
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