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Volume 15, Issue 13

July 15, 2023pp 5956—6621

About the Cover

The cover features Figure 3 "Reprogramming small molecule cocktails restore NCC alterations in senescent cells" from Yang et al.

Editorials

Mitochondrial fitness sustains healthy muscle aging

Andrea Irazoki, Antonio Zorzano, David Sebastián

https://doi.org/10.18632/aging.204857pp 5956—5958

Failure of current Alzheimer’s disease hypotheses

Paul L. Wood

https://doi.org/10.18632/aging.204880pp 5959—5960

Remote cognitive assessment to early detection of cognitive decline

Gabriele Cattaneo, Javier Solana-Sanchez, Josep Maria Tormos-Muñoz

https://doi.org/10.18632/aging.204908pp 5961—5962

Cognitive reserve, neuropathology, and progression towards Alzheimer’s disease

Monica E. Nelson, Ross Andel, Jakub Hort

https://doi.org/10.18632/aging.204909pp 5963—5965

Priority Research Paper

Chemically induced reprogramming to reverse cellular aging

Jae-Hyun Yang, Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Maybury-Lewis, Xiao Tian, Nabilah Ibrahim, Zhili Chen, Patrick T. Griffin, Matthew Arnold, Jien Li, Oswaldo A. Martinez, Alexander Behn, Ryan Rogers-Hammond, Suzanne Angeli, Vadim N. Gladyshev, David A. Sinclair

https://doi.org/10.18632/aging.204896pp 5966—5989

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Research Papers

Cognitive rescue in aging through prior training in rats

Alexandra Gros, Szu-Han Wang

https://doi.org/10.18632/aging.204808pp 5990—6010

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Budding uninhibited by benzimidazoles-1 (BUB1) regulates EGFR signaling by reducing EGFR internalization

Shyam Nyati, Grant Young, Corey Speers, Mukesh K. Nyati, Alnawaz Rehemtulla

https://doi.org/10.18632/aging.204820pp 6011—6030

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MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan

Lorenzo Morè, Lucia Privitera, Daniel D. Cooper, Marianthi Tsogka, J. Simon C. Arthur, Bruno G. Frenguelli

https://doi.org/10.18632/aging.204833pp 6031—6072

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Predicting lifespan-extending chemical compounds for C. elegans with machine learning and biologically interpretable features

Caio Ribeiro, Christopher K. Farmer, João Pedro de Magalhães, Alex A. Freitas

https://doi.org/10.18632/aging.204866pp 6073—6099

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MCF2L-AS1 promotes the biological behaviors of hepatocellular carcinoma cells by regulating the miR-33a-5p/FGF2 axis

Hongliang Ou, Yunsong Qian, Li Ma

https://doi.org/10.18632/aging.204795pp 6100—6116

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Confirmation of the predictive function of cuproptosis-related gene FDX1 in clear cell renal carcinoma using qRT-PCR and western blotting

Congbo Cai, Kena Zhou, Jing Jing, Yu Ren, Guobin Weng, Dong Cen, Xue Wang, Shuaishuai Huang

https://doi.org/10.18632/aging.204807pp 6117—6134

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Identification and characterization of a novel molecular classification based on disulfidptosis-related genes to predict prognosis and immunotherapy efficacy in hepatocellular carcinoma

Li Yang, Weigang Zhang, Yifeng Yan

https://doi.org/10.18632/aging.204809pp 6135—6151

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Machine learning models predict the mTOR signal pathway-related signature in the gastric cancer involving 2063 samples of 7 centers

Hao Zhang, Huiqin Zhuo, Jingjing Hou, Jianchun Cai

https://doi.org/10.18632/aging.204817pp 6152—6162

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PRMT5 facilitates angiogenesis and EMT via HIF-1α/VEGFR/Akt signaling axis in lung cancer

Yonghua Zheng, Huaxia Ji, Wulin Yi, Zhanjun Chen, Xiaobiao Hu, Jie Zhou, Yang Wang, Xiao Zheng

https://doi.org/10.18632/aging.204826pp 6163—6178

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ZNF765 is a prognostic biomarker of hepatocellular carcinoma associated with cell cycle, immune infiltration, m⁶A modification, and drug susceptibility

Yongqi Ding, Yiyang Gong, Hong Zeng, Gelin Song, Zichuan Yu, Bidong Fu, Yue Liu, Da Huang, Yanying Zhong

https://doi.org/10.18632/aging.204827pp 6179—6211

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Treatment of porcine ovarian follicles with tert-butyl hydroperoxide as an ovarian senescence model in vitro

Peihua Shi, Jinchun Gao, Shunran Zhao, Wei Xia, Junjie Li, Chenyu Tao

https://doi.org/10.18632/aging.204831pp 6212—6224

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An integrated bioinformatic investigation of focal adhesion-related genes in glioma followed by preliminary validation of COL1A2 in tumorigenesis

Guojun Yao, Ling Deng, Xinquan Long, Yufan Zhou, Xiang Zhou

https://doi.org/10.18632/aging.204834pp 6225—6254

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Neutrophil-derived S100A8/A9 promotes apoptosis of intestinal epithelial cells in children with duodenal ulcers

Rong Cheng, Xiaowei Xia, Rong Liu, Wenjun Zhang, Juan Du, Maoyan Zhang, Chuanying Li

https://doi.org/10.18632/aging.204842pp 6255—6263

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Identification of natural killer cell-related characteristics to predict the clinical prognosis and immune microenvironment of patients with low-grade glioma

Fei Sun, Hongtao Lv, Baozhi Feng, Jiaao Sun, Linyun Zhang, Bin Dong

https://doi.org/10.18632/aging.204850pp 6264—6291

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Insights into the adverse effects of prepubertal chronic ethanol exposure on adult female reproduction

Qian-Nan Li, Guan-Mei Hou, Si-Min Sun, Wen-Bo Liu, Tie-Gang Meng, Yi Hou, Heide Schatten, Qing-Yuan Sun, Xiang-Hong Ou

https://doi.org/10.18632/aging.204851pp 6292—6301

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Clinical significance, tumor immune landscape and immunotherapy responses of ADAR in pan-cancer and its association with proliferation and metastasis of bladder cancer

Hao Yu, Kexin Bai, Yidong Cheng, Jiancheng Lv, Qiang Song, Haiwei Yang, Qiang Lu, Xiao Yang

https://doi.org/10.18632/aging.204853pp 6302—6330

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MIR34A modulates lens epithelial cell apoptosis and cataract development via the HK1/caspase 3 signaling pathway

Lujia Feng, Yantao Wei, Yimeng Sun, Linbin Zhou, Shaowei Bi, Weirong Chen, Wu Xiang

https://doi.org/10.18632/aging.204854pp 6331—6345

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Identification of key biomarkers in ischemic stroke: single-cell sequencing and weighted co-expression network analysis

Jiali Tao, Xiaochen Xie, Man Luo, Qingsong Sun

https://doi.org/10.18632/aging.204855pp 6346—6360

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Integrating the characteristic genes of macrophage pseudotime analysis in single-cell RNA-seq to construct a prediction model of atherosclerosis

Zemin Tian, Shize Yang

https://doi.org/10.18632/aging.204856pp 6361—6379

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DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway

Chao Sun, Kun Wen, Bin Zhang, Yan Dong, Chen Chen, Shi-Yong Neo, Bing Leng, Tian-Tian Gao, Jing Wu

https://doi.org/10.18632/aging.204858pp 6380—6399

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Exploring Cancer Dependency Map genes and immune subtypes in colon cancer, in which TIGD1 contributes to colon cancer progression

Guoyang Zhang, Zongfeng Feng, Qingwen Zeng, Ping Huang

https://doi.org/10.18632/aging.204859pp 6400—6428

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Procoagulant genes may affect angiogenesis, epithelial-mesenchymal transition, survival prognosis and tumor immune microenvironment in patients with urothelial carcinoma

Bin Li, Yuan Hu, Qiu-yang Li, Yi-Ming Tang, Zhe Lin

https://doi.org/10.18632/aging.204860pp 6429—6444

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A novel cuproptosis-related lncRNAs signature predicts prognosis in bladder cancer

Lingfeng Wu, Wei Chen, Yifang Cao, Bin Chen, Yi He, Xueping Wang

https://doi.org/10.18632/aging.204861pp 6445—6466

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Exploration of cuprotosis-related genes for predicting prognosis and immunological characteristics in acute myeloid leukaemia based on genome and transcriptome

Yanhui Wei, Zhaoxu Miao, Xuejun Guo, Songwei Feng

https://doi.org/10.18632/aging.204864pp 6467—6486

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The development and validation of a nomogram for predicting brain metastases after chemotherapy and radiotherapy in male small cell lung cancer patients with stage III

Baihua Yang, Wei Zhang, Jianjian Qiu, Yilin Yu, Jiancheng Li, Buhong Zheng

https://doi.org/10.18632/aging.204865pp 6487—6502

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Galectin-1-mediated MET/AXL signaling enhances sorafenib resistance in hepatocellular carcinoma by escaping ferroptosis

Tung-Wei Hsu, Yen-Hao Su, Hsin-An Chen, Po-Hsiang Liao, Shih Chiang Shen, Kuei-Yen Tsai, Tzu-Hsuan Wang, Alvin Chen, Chih-Yang Huang, Marthandam Asokan Shibu, Wan-Yu Wang, Shing-Chuan Shen

https://doi.org/10.18632/aging.204867pp 6503—6525

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N6AMT1 is a novel potential diagnostic, prognostic and immunotherapy response biomarker in pan-cancer

Mingqi Wang, Jiajie Zhu, Yingquan Ye, Ping Li, Weijie Sun, Mei Zhang

https://doi.org/10.18632/aging.204868pp 6526—6544

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Comprehensive prognostic and immunological analysis of Ubiquitin Specific Peptidase 28 in pan-cancers and identification of its role in hepatocellular carcinoma cell lines

Wuhan Zhou, Jiafei Chen, Jingui Wang

https://doi.org/10.18632/aging.204869pp 6545—6576

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Review

Crosstalk between m6A and coding/non-coding RNA in cancer and detection methods of m6A modification residues

Qingren Meng, Heide Schatten, Qian Zhou, Jun Chen

https://doi.org/10.18632/aging.204836pp 6577—6619

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Correction

Correction for: Gomisin M2 from Baizuan suppresses breast cancer stem cell proliferation in a zebrafish xenograft model

Yeguo Yang, Erwei Hao, Xianglong Pan, Dechao Tan, Zhengcai Du, Jinling Xie, Xiaotao Hou, Jiagang Deng, Kun Wei

https://doi.org/10.18632/aging.204872pp 6620—6621