Research Paper|Volume 15, Issue 13|pp 6255—6263

Neutrophil-derived S100A8/A9 promotes apoptosis of intestinal epithelial cells in children with duodenal ulcers

Rong Cheng¹, Xiaowei Xia¹, Rong Liu², Wenjun Zhang², Juan Du², Maoyan Zhang¹, Chuanying Li¹

¹Department of Gastroenterology, Children's Medical Center of Anhui Medical University (Anhui Provincial Children’s Hospital), The Fifth Clinical College, Anhui Medical University, Hefei 230051, Anhui, China
²School of Basic Medical Sciences, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui, China

* Equal contribution

Received: February 17, 2023Accepted: June 12, 2023Published: July 12, 2023

https://doi.org/10.18632/aging.204842

Copyright: © 2023 Cheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Duodenal ulcer significantly reduces quality of life and safety in children; however, the mechanism of the pathogenesis in children with duodenal ulcer remains unclear. S100A8/A9, which plays a critical role in the occurrence and development of inflammation, has attracted a lot of interest recently. Here, we identified that S100A8/A9 are highly expressed in the serum of children with duodenal ulcers, and this is of excellent diagnostic value. Animal experiments have proved that inhibition of S100A8/A9 can repair ulcer progression. In addition, further study has shown that S100A8/A9, mainly produced by neutrophil, can enhance the apoptosis of intestinal epithelial cells and promote the growth in children with duodenal ulcers. Thus, our research proves the value of S100A8/A9 in the diagnosis and treatment of children with duodenal ulcers.