Volume 12, Issue 17

September 15, 2020pp 16665—17753

About the Cover

The cover features Figure 1 "Heatmap clustered by Euclidean distance of changes in plasma metabolite concentrations“ from Yakhine-Diop et al.

Editorials

Mitochondrial oxidative phosphorylation is linked to T-cell exhaustion

Shuai Jiang

https://doi.org/10.18632/aging.103995pp 16665—16666

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The sex chromosomes of the aging epigenome

Qihua Tan

https://doi.org/10.18632/aging.104033pp 16667—16668

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Human skeletal stem cell aging

Thomas H. Ambrosi, L. Henry Goodnough, Charles K.F. Chan

https://doi.org/10.18632/aging.104034pp 16669—16671

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Letter to the Editor

A newborn with normal IgM and elevated IgG antibodies born to an asymptomatic infection mother with COVID-19

Wenqi Gao, Zhifang Deng, Lingkong Zeng, Yuan Yang, HongJian Gong, Jue Liu, Han Xiao

https://doi.org/10.18632/aging.103346pp 16672—16674

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Research Papers

Clinical course and risk factors for recurrence of positive SARS-CoV-2 RNA: a retrospective cohort study from Wuhan, China

Jie Chen, Xiaoping Xu, Jing Hu, Qiangda Chen, Fengfeng Xu, Hui Liang, Nanmei Liu, Hengmei Zhu, Jinlong Lan, Lan Zhou, Jiajun Xing, Ning Pu, Zhigang Cai

https://doi.org/10.18632/aging.103795pp 16675—16689

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Metabolic alterations in plasma from patients with familial and idiopathic Parkinson’s disease

Sokhna M.S. Yakhine-Diop, José A. Morales-García, Mireia Niso-Santano, Rosa A. González-Polo, Elisabet Uribe-Carretero, Guadalupe Martinez-Chacon, Sylvere Durand, Maria Chiara Maiuri, Ana Aiastui, Miren Zulaica, Javier Ruíz-Martínez, Adolfo López de Munain, Jordi Pérez-Tur, Ana Pérez-Castillo, Guido Kroemer, José M. Bravo-San Pedro, José M. Fuentes

https://doi.org/10.18632/aging.103992pp 16690—16708

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Discovering correlates of age-related decline in a healthy late-midlife male birth cohort

Kiyana Zarnani, Stephen M. Smith, Fidel Alfaro-Almagro, Birgitte Fagerlund, Martin Lauritzen, Egill Rostrup, Thomas E. Nichols

https://doi.org/10.18632/aging.103345pp 16709—16743

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Cancer mortality in the oldest old: a global overview

Dana Hashim, Greta Carioli, Matteo Malvezzi, Paola Bertuccio, Samuel Waxman, Eva Negri, Carlo La Vecchia, Paolo Boffetta

https://doi.org/10.18632/aging.103503pp 16744—16758

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HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML

Feiteng Huang, Jie Sun, Wei Chen, Xin He, Yinghui Zhu, Haojie Dong, Hanying Wang, Zheng Li, Lei Zhang, Samer Khaled, Guido Marcucci, Jinwen Huang, Ling Li

https://doi.org/10.18632/aging.103605pp 16759—16774

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Identification of cardiovascular health gene variants related to longevity in a Chinese population

Li Zhang, Chen Bai, Chao Nie, Xiaoquan Zhu, Huiping Yuan, Liang Sun, Qi Zhou, Xiaoling Li, Xuan Xian, Fan Yang, Guofang Pang, Yuan Lv, Xiaolin Ni, Caiyou Hu, Ze Yang

https://doi.org/10.18632/aging.103396pp 16775—16802

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Anchorage independence altered vasculogenic phenotype of melanoma cells through downregulation in aminopeptidase N /syndecan-1/integrin β4 axis

Yu-Che Cheng, Wei-Chi Ku, Ting-Ting Tseng, Ching-Po Wu, Mengjin Li, Shao-Chen Lee

https://doi.org/10.18632/aging.103425pp 16803—16819

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Neutrophil extracellular traps amplify neutrophil recruitment and inflammation in neutrophilic asthma by stimulating the airway epithelial cells to activate the TLR4/ NF-κB pathway and secrete chemokines

Rongjun Wan, Juan Jiang, Chengping Hu, Xi Chen, Cen Chen, Bingrong Zhao, Xinyue Hu, Zhiyuan Zheng, Yuanyuan Li

https://doi.org/10.18632/aging.103479pp 16820—16836

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Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells

Juntao Li, Yan Zhou, Yuting Yan, Zhongnan Zheng, Yabin Hu, Wei Wu

https://doi.org/10.18632/aging.103537pp 16837—16851

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Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans

Xin Yang, Mohan Zhang, Yuhua Dai, Yuchao Sun, Yahyah Aman, Yuying Xu, Peilin Yu, Yifan Zheng, Jun Yang, Xinqiang Zhu

https://doi.org/10.18632/aging.103578pp 16852—16866

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Oxidative stress, apoptosis and inflammatory responses involved in copper-induced pulmonary toxicity in mice

Zhijie Jian, Hongrui Guo, Huan Liu, Hengmin Cui, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao

https://doi.org/10.18632/aging.103585pp 16867—16886

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Celastrol regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing PGC-1α signaling

Li Li, Bing Wang, Yawei Li, Lei Li, Yuliang Dai, Guohua Lv, Pengfei Wu, Pengzhi Li

https://doi.org/10.18632/aging.103590pp 16887—16898

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Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes

Xing-Hua Pan, Qing-Keng Lin, Xiang Yao, Zi-An Li, Xue-Min Cai, Rong-Qing Pang, Guang-Ping Ruan

https://doi.org/10.18632/aging.103594pp 16899—16920

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Epigenetic upregulation of HOXC10 in non-small lung cancer cells

Miao Li, John Simon Alsager, Zhaokai Wang, Lin Cheng, Bin Shan

https://doi.org/10.18632/aging.103597pp 16921—16935

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Long non-coding RNA FAM133B-2 represses the radio-resistance of nasopharyngeal cancer cells by targeting miR-34a-5p/CDK6 axis

Dabing Huang, Xianhai Zhu, Yong Wang, Haobin Yu, Youguang Pu

https://doi.org/10.18632/aging.103600pp 16936—16950

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Esculentoside A rescues granulosa cell apoptosis and folliculogenesis in mice with premature ovarian failure

Zhenteng Liu, Fenghua Li, Jingwen Xue, Meimei Wang, Shoucui Lai, Hongchu Bao, Shunzhi He

https://doi.org/10.18632/aging.103609pp 16951—16962

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PGC-1α and ERRα in patients with endometrial cancer: a translational study for predicting myometrial invasion

LiLi Chen, XiaoDan Mao, MeiMei Huang, HuiFang Lei, LiFang Xue, PengMing Sun

https://doi.org/10.18632/aging.103611pp 16963—16980

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Annotation of susceptibility SNPs associated with atrial fibrillation

Chengqi Xu, Rongfeng Zhang, Yunlong Xia, Liang Xiong, Wei Yang, Pengyun Wang

https://doi.org/10.18632/aging.103615pp 16981—16998

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The association of healthy behaviors with cognitive health expectancy in Chinese older adults: a population-based cohort study

Chengbei Hou, Yinan Lin, Zachary Zimmer, Xianghua Fang

https://doi.org/10.18632/aging.103617pp 16999—17021

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Retrospective study of gene signatures and prognostic value of m6A regulatory factor in non-small cell lung cancer using TCGA database and the verification of FTO

Hongjie Shi, Jinping Zhao, Linzhi Han, Ming Xu, Kaijie Wang, Jiajun Shi, Zhe Dong

https://doi.org/10.18632/aging.103622pp 17022—17037

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A novel hypoxic tumor microenvironment signature for predicting the survival, progression, immune responsiveness and chemoresistance of glioblastoma: a multi-omic study

Zihao Wang, Lu Gao, Xiaopeng Guo, Yaning Wang, Yu Wang, Wenbin Ma, Yi Guo, Bing Xing

https://doi.org/10.18632/aging.103626pp 17038—17061

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Evidence that dysplasia related microRNAs in Barrett’s esophagus target PD-L1 expression and contribute to the development of esophageal adenocarcinoma

Juanjuan Xu, Zhongyuan Yin, Lin Yang, Feng Wu, Jinshuo Fan, Qi Huang, Yang Jin, Guanghai Yang

https://doi.org/10.18632/aging.103634pp 17062—17078

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High expression of UNC5B enhances tumor proliferation, increases metastasis, and worsens prognosis in breast cancer

Shijie Wu, Xinyue Guo, Jiaojiao Zhou, Xuan Zhu, Huihui Chen, Kun Zhang, Yuexin Lu, Yiding Chen

https://doi.org/10.18632/aging.103639pp 17079—17098

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Sirt6 is required for spermatogenesis in mice

Huafang Wei, Muhammad Babar Khawar, Wenhao Tang, Lina Wang, Liying Wang, Chao Liu, Hui Jiang, Wei Li

https://doi.org/10.18632/aging.103641pp 17099—17113

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miR-345-5p regulates adipogenesis via targeting VEGF-B

Xiaofeng Liu, Yang He, Zhaolan Feng, Jianjian Sheng, Aiwu Dong, Meiying Zhang, Lingling Cao

https://doi.org/10.18632/aging.103649pp 17114—17121

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Long non-coding RNA SNHG12 promotes immune escape of ovarian cancer cells through their crosstalk with M2 macrophages

Min Qian, Wanwen Ling, Zhengyi Ruan

https://doi.org/10.18632/aging.103653pp 17122—17136

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The protective effects of dehydrocostus lactone against TNF-α-induced degeneration of extracellular matrix (ECM) in SW1353 cells

Lin Wang, Min Yang, Chi Zhang, Fei Huang

https://doi.org/10.18632/aging.103657pp 17137—17149

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LNK deficiency decreases obesity-induced insulin resistance by regulating GLUT4 through the PI3K-Akt-AS160 pathway in adipose tissue

Xiaozhu Zhong, Chuanfeng Ke, Zhaoxi Cai, Hao Wu, Yang Ye, Xiaolin Liang, Liqun Yu, Sushi Jiang, Jun Shen, Laiyou Wang, Meiqing Xie, Guanlei Wang, Xiaomiao Zhao

https://doi.org/10.18632/aging.103658pp 17150—17166

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SNAI1 is a prognostic biomarker and correlated with immune infiltrates in gastrointestinal cancers

Jiaying Fang, Zan Ding

https://doi.org/10.18632/aging.103667pp 17167—17208

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CircRNA circ_0072995 promotes the progression of epithelial ovarian cancer by modulating miR-147a/CDK6 axis

Jin Ding, Qingwei Wang, Nan Guo, Hao Wang, He Chen, Guantai Ni, Peiling Li

https://doi.org/10.18632/aging.103668pp 17209—17223

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Dynamic changes in vascular size and density in transgenic mice with Alzheimer’s disease

Xiaowen Xu, Tong Meng, Qingqing Wen, Mengling Tao, Peijun Wang, Kai Zhong, Yong Shen

https://doi.org/10.18632/aging.103672pp 17224—17234

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Mitophagy impairment is involved in sevoflurane-induced cognitive dysfunction in aged rats

Yeru Chen, Piao Zhang, Xianyi Lin, Huan Zhang, Jiamin Miao, Youfa Zhou, Gang Chen

https://doi.org/10.18632/aging.103673pp 17235—17256

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Inactive bowel movement and stroke are associated with increased risks of mild cognitive impairment among community-living Singapore elderly

Kai-Yong Huang, Xian-Yan Tang, Li Yang, Zhi-Yong Zhang, Kaisy Xinhong Ye, Qing-Feng Shen, Xiu Wang, Xiang-Hua Zhu, Xiao-Wei Huang, Guo-Dong Lu, Lei Feng

https://doi.org/10.18632/aging.103674pp 17257—17270

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Profiling of circular RNAs in age-related cataract reveals circZNF292 as an antioxidant by sponging miR-23b-3p

Shuqi Liang, Shengqian Dou, Wenfeng Li, Yusen Huang

https://doi.org/10.18632/aging.103683pp 17271—17287

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Male patients with TERT mutation may be more likely to benefit from immunotherapy, especially for melanoma

Jia Li, Zhaoyan Li, Chenyue Zhang, Chenxing Zhang, Haiyong Wang

https://doi.org/10.18632/aging.103684pp 17288—17294

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Relation between left atrial structure and lacunar infarction in patients with hypertension

Ting Sun, Tong Xie, Alian Zhang, Li Fan, Zuojun Xu, Xin Chen, Zhicheng Fan, Changqian Wang

https://doi.org/10.18632/aging.103697pp 17295—17304

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Chloride intracellular channel protein 2: prognostic marker and correlation with PD-1/PD-L1 in breast cancer

Tao Xu, Zhi Wang, Menglu Dong, Di Wu, Shujie Liao, Xingrui Li

https://doi.org/10.18632/aging.103712pp 17305—17327

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Functional connectivity network estimation with an inter-similarity prior for mild cognitive impairment classification

Weikai Li, Xiaowen Xu, Wei Jiang, Peijun Wang, Xin Gao

https://doi.org/10.18632/aging.103719pp 17328—17342

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High hsa_circ_0020123 expression indicates poor progression to non-small cell lung cancer by regulating the miR-495/HOXC9 axis

Rui Bi, Wei Wei, Yunhui Lu, Fengqing Hu, Xuhui Yang, Yuan Zhong, Lifei Meng, Mingsong Wang, Lianyong Jiang, Xiao Xie

https://doi.org/10.18632/aging.103722pp 17343—17352

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Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury

Yan Sun, Shiting Dai, Jin Tao, Yunlong Li, Ziqi He, Quan Liu, Jiawen Zhao, Yaoliang Deng, Juening Kang, Xuepei Zhang, Sixing Yang, Yunlong Liu

https://doi.org/10.18632/aging.103730pp 17353—17366

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G-protein coupled estrogen receptor activation protects the viability of hyperoxia-treated primary murine retinal microglia by reducing ER stress

Rong Li, Yao Wang, Pei Chen, Jiamin Meng, Hongbing Zhang

https://doi.org/10.18632/aging.103733pp 17367—17379

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Identification of a cullin5-RING E3 ligase transcriptome signature in glioblastoma multiforme

Shuhua Zheng, Zhenhao Li

https://doi.org/10.18632/aging.103737pp 17380—17392

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Physical performance and chronic kidney disease development in elderly adults: results from a nationwide cohort study

Young Su Joo, Jong Hyun Jhee, Hyung-Woo Kim, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Jung Tak Park

https://doi.org/10.18632/aging.103741pp 17393—17417

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Identification of subtype-specific genes signature by WGCNA for prognostic prediction in diffuse type gastric cancer

Qi Zhou, Li-Qiang Zhou, Shi-Hao Li, Yi-Wu Yuan, Li Liu, Jin-Liang Wang, Deng-Zhong Wu, You Wu, Lin Xin

https://doi.org/10.18632/aging.103743pp 17418—17435

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Jinmaitong ameliorates diabetic peripheral neuropathy in streptozotocin-induced diabetic rats by modulating gut microbiota and neuregulin 1

Jun Xie, Wei Song, Xiaochun Liang, Qian Zhang, Yue Shi, Wei Liu, Xiaohu Shi

https://doi.org/10.18632/aging.103750pp 17436—17458

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LINC00160 mediates sunitinib resistance in renal cell carcinoma via SAA1 that is implicated in STAT3 activation and compound transportation

Gong Cheng, Yuenan Liu, Lilong Liu, Hailong Ruan, Qi Cao, Zhengshuai Song, Lin Bao, Tianbo Xu, Zhiyong Xiong, Jingchong Liu, Di Liu, Huageng Liang, Guosong Jiang, Xiong Yang, Hongmei Yang, Ke Chen, Xiaoping Zhang

https://doi.org/10.18632/aging.103755pp 17459—17479

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Fecal microbiota transplantation alters the susceptibility of obese rats to type 2 diabetes mellitus

Lijing Zhang, Wen Zhou, Libin Zhan, Shenglin Hou, Chunyan Zhao, Tingting Bi, Xiaoguang Lu

https://doi.org/10.18632/aging.103756pp 17480—17502

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Transcriptome analysis of duck embryo fibroblasts for the dynamic response to duck tembusu virus infection and dual regulation of apoptosis genes

Yuhong Pan, Anchun Cheng, Xingcui Zhang, Mingshu Wang, Shun Chen, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Juan Huang, Shaqiu Zhang, Sai Mao, Xumin Ou, Qun Gao, Yanling Yu, Yunya Liu, Ling Zhang, Zhongqiong Yin, Bo Jing, Bin Tian, Leichang Pan, Mujeeb Ur Rehman, Xiaoyue Chen, Renyong Jia

https://doi.org/10.18632/aging.103759pp 17503—17527

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Two identified subsets of CD8 T cells in obstructed kidneys play different roles in inflammation and fibrosis

Juan Wang, Jijing Tian, Jian Sun, Min Gao, Yanjun Dong

https://doi.org/10.18632/aging.103764pp 17528—17540

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BRD4/8/9 are prognostic biomarkers and associated with immune infiltrates in hepatocellular carcinoma

Yi-Ru Chen, Su-Shan Ouyang, Yan-Ling Chen, Ping Li, Hui-Wen Xu, Sen-Lin Zhu

https://doi.org/10.18632/aging.103768pp 17541—17567

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HSPB8 overexpression prevents disruption of blood-brain barrier after intracerebral hemorrhage in rats through Akt/GSK3β/β-catenin signaling pathway

Ying Hou, Zhiping Hu, Xiyu Gong, Binbin Yang

https://doi.org/10.18632/aging.103773pp 17568—17581

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Metformin suppresses Nrf2-mediated chemoresistance in hepatocellular carcinoma cells by increasing glycolysis

Liangyu Cai, Xin Jin, Jiannan Zhang, Le Li, Jinfeng Zhao

https://doi.org/10.18632/aging.103777pp 17582—17600

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Parietal epithelial cell differentiation to a podocyte fate in the aged mouse kidney

Natalya V. Kaverina, Diana G. Eng, Jeffrey H. Miner, Jeffrey W. Pippin, Stuart J. Shankland

https://doi.org/10.18632/aging.103788pp 17601—17624

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Graphene oxide inhibits cell migration and invasion by destroying actin cytoskeleton in cervical cancer cells

Jing Wang, Ping Wang, Ying He, Xiaoli Liu, Sisi Wang, Chunxing Ma, Xiaofei Tian, Jing Wang, Xin Wu

https://doi.org/10.18632/aging.103821pp 17625—17633

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DUSP4 directly deubiquitinates and stabilizes Smad4 protein, promoting proliferation and metastasis of colorectal cancer cells

Weifeng Xu, Beibei Chen, Dianshan Ke, Xiaobing Chen

https://doi.org/10.18632/aging.103823pp 17634—17646

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Identification and prognostic value of metabolism-related genes in gastric cancer

Fang Wen, Jiani Huang, Xiaona Lu, Wenjie Huang, Yulan Wang, Yingfeng Bai, Shuai Ruan, Suping Gu, Xiaoxue Chen, Peng Shu

https://doi.org/10.18632/aging.103838pp 17647—17661

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Shikonin overcomes drug resistance and induces necroptosis by regulating the miR-92a-1-5p/MLKL axis in chronic myeloid leukemia

Xianbo Huang, Zhenzhen Chen, Fan Ni, Xiujin Ye, Wenbin Qian

https://doi.org/10.18632/aging.103844pp 17662—17680

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Long non-coding RNA Loc490 inhibits gastric cancer cell proliferation and metastasis by upregulating RNA-binding protein Quaking

Zhengxi He, Zhaojun Duan, Ling Chen, Bin Li, Yanhong Zhou

https://doi.org/10.18632/aging.103876pp 17681—17693

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Preclinical studies show using enzalutamide is less effective in docetaxel-pretreated than in docetaxel-naïve prostate cancer cells

Changyi Lin, Fu-Ju Chou, Jieyang Lu, Wanying Lin, Matthew Truong, Hao Tian, Yin Sun, Jie Luo, Rachel Yang, Yuanjie Niu, Rosa Nadal, Emmanuel S. Antonarakis, Carlos Cordon-Cardo, Deepak Sahasrabudhe, Chi-Ping Huang, Shuyuan Yeh, Gonghui Li, Chawnshang Chang

https://doi.org/10.18632/aging.103917pp 17694—17712

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