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Editorial

Aging retinal pigmented epithelium: omics-based insights into vision decline

Ioan V. Matei, Luminita Paraoan,
https://doi.org/10.18632/aging.205914
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Research Papers

Aging exacerbates oxidative stress and liver fibrosis in an animal model of Down Syndrome

Sebastiano Giallongo, Jessica Ferrigno, Rosario Caltabiano, Giuseppe Broggi, Amer M. Alanazi, Alfio Distefano, Emanuela Tropea, Antonella Tramutola, Marzia Perluigi, Giovanni Li Volti, Eugenio Barone, Ignazio Alberto Barbagallo,
https://doi.org/10.18632/aging.205970
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Roles of pigment epithelium-derived factor in exercise-induced suppression of senescence and its impact on lung pathology in mice

Hiromichi Tsushima, Hirobumi Tada, Azusa Asai, Mikako Hirose, Tohru Hosoyama, Atsushi Watanabe, Taro Murakami, Masataka Sugimoto,
https://doi.org/10.18632/aging.205976
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Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells

Joseph S. Spina, Tracy L. Carr, Lucy A. Phillips, Heather L. Knight, Nancy E. Crosbie, Sarah M. Lloyd, Manisha A. Jhala, Tony J. Lam, Jozsef Karman, Meghan E. Clements, Tovah A. Day, Justin D. Crane, William J. Housley,
https://doi.org/10.18632/aging.205994
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CCNA2 and KIF23 are molecular targets for the prognosis of adenoid cystic carcinoma

Yongbin Di, Haolei Zhang, Bohao Zhang, Tianke Li, Dan Li,
https://doi.org/10.18632/aging.205703
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SHP2 mediates STAT3/STAT6 signaling pathway in TAM to inhibit proliferation and metastasis of lung adenocarcinoma

Guojing Chai, Yingbo Nan, Haili Zhao, Qingchuan Hu,
https://doi.org/10.18632/aging.205799
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RGC32 promotes the progression of ccRCC by activating the NF-κB/SHP2/EGFR signaling pathway

Jing Zhang, Yindi Sun, Kai Tang, Huirong Xu, Junjuan Xiao, Yan Li,
https://doi.org/10.18632/aging.205890
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Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration

Si-Kuan Zheng, Xiao-Kun Zhao, Hui Wu, Ding-Wen He, Long Xiong, Xi-Gao Cheng,
https://doi.org/10.18632/aging.205920
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MiR-33a-5p in stored red blood cells regulates genes of innate immune response and promotes inflammation

Jingrui Zhang, Dan Zhang, Jing Zhao, Wei Zheng,
https://doi.org/10.18632/aging.205925
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Characterization of tumor endothelial cells (TEC) in gastric cancer and development of a TEC-based risk signature using single-cell RNA-seq and bulk RNA-seq data

Meng Fan, Xiaofei Xu, Yu Hu,
https://doi.org/10.18632/aging.205928
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Reduced expression of E-cadherin correlates with poor prognosis and unfavorable clinicopathological features in gastric carcinoma: a meta-analysis

Genlin Lu, Zhai Cai, Renya Jiang, Fei Tong, Jinming Tu, Yandong Chen, Yinglan Fu, Jingyi Sun, Tao Zhang,
https://doi.org/10.18632/aging.205929
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Mining key circadian biomarkers for major depressive disorder by integrating bioinformatics and machine learning

Yuhe Shi, Jue Zhu, Chaowen Hou, Xiaoling Li, Qiaozhen Tong,
https://doi.org/10.18632/aging.205930
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Identification of VEGFs-related gene signature for predicting microangiogenesis and hepatocellular carcinoma prognosis

Shengpan Jiang, Guoting Zhu, Yiqing Tan, Tao Zhou, Shilin Zheng, Fuhua Wang, Wenfeng Lei, Xuan Liu, Jinjun Du, Manman Tian,
https://doi.org/10.18632/aging.205931
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Identification of JUN gene and cellular microenvironment in response to PD-1 blockade treatment in lung cancer patients via single-cell RNA sequencing

Yuxuan Wang, Tao Ran, Yunke Li, Lei Tian, Lifeng Yang, Zhidong Liu, Biao Yao,
https://doi.org/10.18632/aging.205932
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Genetically predicted 91 circulating inflammatory proteins in relation to risk of urological malignancies: a Mendelian randomization study

Jianxiong Xu, Ru Chen, Yucheng Yang, Sufang Xu, Lijing Yao,
https://doi.org/10.18632/aging.205934
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Therapeutic targets of formononetin for treating prostate cancer at the single-cell level

Jiawei Li, Zhaoquan Huang, Ping Wang, Rong Li, Li Gao, Keng Po Lai,
https://doi.org/10.18632/aging.205935
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Application of angiogenesis-related genes associated with immune infiltration in the molecular typing and diagnosis of acute myocardial infarction

Guoqing Liu, Wang Liao, Xiangwen Lv, Miaomiao Zhu, Xingqing Long, Jian Xie,
https://doi.org/10.18632/aging.205936
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The beneficial effects of Rosuvastatin in inhibiting inflammation in sepsis

Ziming Tang, Zheng Ning, Zexuan Li,
https://doi.org/10.18632/aging.205937
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Inhibition of non-small cell lung cancer metastasis by knocking down APE1 through regulating myeloid-derived suppressor cells-induced immune disorders

Zhenlong Zhang, Yuchen Lin, Xiaojie Pan, Shuchen Chen,
https://doi.org/10.18632/aging.205938
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Notoginsenoside R1 (NGR1) regulates the AGE-RAGE signaling pathway by inhibiting RUNX2 expression to accelerate ferroptosis in breast cancer cells

Wenxin Li, Yan Guo, Zhuangyu Xu, Fubo Li, Yi Dong, Fan Xu,
https://doi.org/10.18632/aging.205940
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MATN4 as a target gene of HIF-1α promotes the proliferation and metastasis of osteosarcoma

Lu Zhang, Yujie Pan, Feng Pan, Songsong Huang, Fengyan Wang, Zhirui Zeng, Houping Chen, Xiaobin Tian,
https://doi.org/10.18632/aging.205941
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Causal role of immune cells in prostate cancer: a bidirectional Mendelian-randomization analyses

Mingyan Zhong, Xiangpeng Zhan, Fang-Ping Zhong,
https://doi.org/10.18632/aging.205942
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Identification of a signature of histone modifiers in kidney renal clear cell carcinoma

Yongming Huang, Zhongsheng Yang, Ying Tang, Hua Chen, Tairong Liu, Guanghua Peng, Xin Huang, Xiaolong He, Ming Mei, Chuance Du,
https://doi.org/10.18632/aging.205944
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The crosstalk role of CDKN2A between tumor progression and cuproptosis resistance in colorectal cancer

Xifu Cheng, Famin Yang, Yuanheng Li, Yuke Cao, Meng Zhang, Jiameng JI, Yuxiao Bai, Qing Li, Qiongfang Yu, Dian Gao,
https://doi.org/10.18632/aging.205945
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Precision prognostication in breast cancer: unveiling a long non-coding RNA-based model linked to disulfidptosis for tailored immunotherapeutic strategies

Chenglu Jiang, Shengke Zhang, Lai Jiang, Zipei Chen, Haiqing Chen, Jinbang Huang, Xuancheng Zhou, Jingyi Tang, Xinrui Gao, Hao Chi, Guanhu Yang, Shangke Huang,
https://doi.org/10.18632/aging.205946
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Long non-coding RNA HOTTIP promotes renal cell carcinoma progression through the regulation of the miR-506 pathway

Chengyao Zhang, Zhiya Hu, Yongxin Fu, Jiawu Wang,
https://doi.org/10.18632/aging.205947
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Prognostic relevance and validation of ARPC1A in the progression of low-grade glioma

Jingyuan Dai, Jiahui Gao, Hongchao Dong,
https://doi.org/10.18632/aging.205952
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Diagnostic value of galectin-3, fractalkine, IL-6, miR-21 and cardiac troponin I in human ischemic cardiomyopathy

Le Wang, Min Li, Mingqi Zheng, Yida Tang, Zhiyu Yang, Guoping Ma, Qinghou Zheng, Liu Li, Yu Wang, Fangfang Ma, Gang Liu,
https://doi.org/10.18632/aging.205953
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Cathepsin L induces cellular senescence by upregulating CUX1 and p16INK4a

Yuwei Wu, Danli Jiang, Qing Liu, Shaoyang Yan, Xiuzhen Liu, Ting Wu, Wei Sun, Gang Li,
https://doi.org/10.18632/aging.205955
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Identification of differentially expressed genes to predict the risk of heart failure in older patients with hypertrophic cardiomyopathy

Hao Dong, Chufan Yin, Dongping Xiao, Yong Tang,
https://doi.org/10.18632/aging.205956
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NAT1 inhibits liver metastasis of colorectal cancer by regulating EMT and glycolysis

Wang Gu, Chen Li, Tingting Shen, Li Tong, Wenkang Yuan, Xiaofei Zheng, Tianqi Wang, Siyu Wang, Benshuai Zhu, Chong Zhang, Chao Zhang,
https://doi.org/10.18632/aging.205957
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Needle-scalpel therapy inhibits the apoptosis of nucleus pulposus cells via the SDF-1/CXCR4 axis in a rat degenerative cervical intervertebral disc model

Wenlong Yang, Muqing Liu, Qinran Sun, Lei Liu, Wenqing Wu, Fangming Liu, Zhizhen Liu,
https://doi.org/10.18632/aging.205959
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Identifying novel circadian rhythm biomarkers for diagnosis and prognosis of melanoma by an integrated bioinformatics and machine learning approach

Yi Xu, Churuo Zeng, Jie Bin, Hua Tang, Wei Li,
https://doi.org/10.18632/aging.205961
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Prescription glucocorticoid medication and iridocyclitis are associated with an increased risk of senile cataract occurrence: a Mendelian randomization study

Rui Wen, Yu-Jia Xi, Ran Zhang, Si-Jia Hou, Jin-Yu Shi, Jin-Yi Chen, He-Yi Zhang, Jun Qiao, Yi-Qian Feng, Sheng-Xiao Zhang,
https://doi.org/10.18632/aging.205963
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Multi omics analysis of mitophagy subtypes and integration of machine learning for predicting immunotherapy responses in head and neck squamous cell carcinoma

Junzhi Liu, Huimin Li, Qiuping Dong, Zheng Liang,
https://doi.org/10.18632/aging.205964
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Identification and validation of key genes in gastric cancer: insights from in silico analysis, clinical samples, and functional assays

Xiaofeng Pei, Yuanling Luo, Huanwen Zeng, Muhammad Jamil, Xiaodong Liu, Bo Jiang,
https://doi.org/10.18632/aging.205965
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Comprehensive single-cell and bulk RNA-seq analyses reveal a novel CD8+ T cell-associated prognostic signature in ovarian cancer

Yi-Ling Han, Zhou Fang, Zhi-Jie Gao, Wen-Ge Li, Jing Yang,
https://doi.org/10.18632/aging.205966
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Identification of immunotherapy-related subtypes, characterization of tumor microenvironment infiltration, and development of a prognostic signature in gastric carcinoma

Jianxin Li, Ting Han, Jieyi Yang, Xin Wang, Yinchun Wang, Rui Yang, Qingqiang Yang,
https://doi.org/10.18632/aging.205968
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Luteolin targets the AGE-RAGE signaling to mitigate inflammation and ferroptosis in chronic atrophic gastritis

Nailin Zhang, Pingping Chen, Xiaoyan Liang, Jianhui Sun, Qiquan Liu, Shengjiang Guan, Qiao Wang,
https://doi.org/10.18632/aging.205969
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Exploring the mechanism by which Angelica sinensis improves haematopoietic function in aplastic anaemia

Zetao Chen, Li Cheng, Jing Zhang, Xing Cui,
https://doi.org/10.18632/aging.205971
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Cyclin L1 participates in Adriamycin resistance and progression of osteosarcoma via PI3K/AKT-mTOR pathway

Yanbin Zhang, Tao Zhang, Long Chen, Zijun Guo, Xiaobing Jiang,
https://doi.org/10.18632/aging.205972
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Exploring the prognostic analysis of autophagy and tumor microenvironment based on monocyte cells in lung cancer

Bo Tao, Ziming Wang, Dacheng Xie, Hongxue Cui, Bin Zhao, Juanjuan Li, Liang Guo,
https://doi.org/10.18632/aging.205973
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Unfolding the mysteries of heterogeneity from a high-resolution perspective: integration analysis of single-cell multi-omics and spatial omics revealed functionally heterogeneous cancer cells in ccRCC

Jie Zheng, Wenhao Lu, Chengbang Wang, Shaohua Chen, Qingyun Zhang, Cheng Su,
https://doi.org/10.18632/aging.205974
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Pan-cancer analysis of T-cell proliferation regulatory genes as potential immunotherapeutic targets

Ruqiong Wei, Shihui Xiao, Shijian Zhao, Wenliang Guo, Ying Liu, Marìa del Mar Requena Mullor, Raquel Alarcòn Rodrìguez, Qingjun Wei, Yinteng Wu,
https://doi.org/10.18632/aging.205977
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Single-cell immune escape correlation analysis: unraveling the prognostic influence of intercellular communication in the tumor microenvironment of colorectal cancer

Qixin Gan, Haifen Liu, Fangting Tang, Hong Wang, Liang Zhang, Ruoxuan Wang, Yuejun Li,
https://doi.org/10.18632/aging.205978
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Integrative pan-cancer analysis reveals the prognostic and immunotherapeutic value of ALKBH7 in HNSC

Tianyu Wang, Bojian Lin, Boyu Cai, Zhiwen Cao, Caiquan Liang, Shunyu Wu, Enhong Xu, Li Li, Hu Peng, Huanhai Liu,
https://doi.org/10.18632/aging.205981
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An updated immunosenescence exploration in healthy Chinese donors: circular elevated PD-1 on T cell and increased Ki67 on CD8+ T cell towards aging

Yue Chang, Wei Cao, Lianfeng Lu, Yang Han, Lin Qin, Baotong Zhou, Taisheng Li,
https://doi.org/10.18632/aging.205985
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Identification of Escherichia coli strains using MALDI-TOF MS combined with long short-term memory neural networks

Qiqi Mao, Xie Zhang, Zeping Xu, Ya Xiao, Yufei Song, Feng Xu,
https://doi.org/10.18632/aging.205995
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Local anesthetic levobupivacaine induces ferroptosis and inhibits progression by up-regulating p53 in non-small cell lung cancer

Minghua Meng, Meiling Huang, Cuicui Liu, Jiming Wang, Weihua Ren, Shaomin Cui, Jianhua Gu, Jinlan Xie, Bin Ma, Guangzhu Yang, Shuncheng He,
https://doi.org/10.18632/aging.203138
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Identification of an immune subtype predicting survival risk and immune activity in hepatocellular carcinoma

Feng Zhao, Nuo Xu, Jiali Yang, Bo Li, Jianwei Shi, Yuanyuan Zheng, Longjin Xu,
https://doi.org/10.18632/aging.202953
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Review

Senescent cell-derived vaccines: a new concept towards an immune response against cancer and aging?

João Pessoa, Sandrina Nóbrega-Pereira, Bruno Bernardes de Jesus,
https://doi.org/10.18632/aging.205975
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