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Online ISSN: 1945-4589
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12-20-2021
Aging-US published " Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test " which reported that a retrospective analysis of DNA methylation age…
12-20-2021
Aging-US published " Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy " which reported however, whether mitochondrial dysfunction occurs prior to the detection of tau aggregates in tauopathies remains elusive. Here, the authors utilized transgenic nematodes expressing…
12-20-2021
Aging-US published " Early elevation of BACE1 in dementia " which reported that interest in the role of Beta-secretase1 in Alzheimer’s disease pathogenesis and patho- physiology has been remarkably growing in the last 10 years. This transmembrane aspartyl protease catalyzes the rate-limiting step of the sequential…
11-01-2021
Aging-US published " Effects of estradiol on biological age measured using the glycan age index " which reported that glycan age is a recently developed biomarker based on glycans attached to immunoglobulin G. In large population cohorts, glycan age associates well with lifestyle and disease-risk biomarkers, while…
10-25-2021
Aging-US published " Involvement of cerebrovascular abnormalities in the pathogenesis and progression of Alzheimer’s disease: an adrenergic approach " which reported that alzheimer’s disease, as the most common neurodegenerative disease in elder population, is pathologically characterized by β-amyloid plaques,…
10-25-2021
Aging-US published " Calorie intake rather than food quantity consumed is the key factor for the anti-aging effect of calorie restriction " which reported that although calorie restriction has been reported to extend lifespan in several organisms, animals subjected to calorie restriction consume not only fewer…
10-25-2021
Aging-US published " Hyperbaric oxygen therapy alleviates vascular dysfunction and amyloid burden in an Alzheimer’s disease mouse model and in elderly patients " which reported that In the current study, the authors exposed 5XFAD mice, a well-studied AD model that presents impaired cognitive abilities, to HBOT and…
10-25-2021
Aging-US published " Applying deductive reasoning and the principles of particle physics to aging research " which reported that aging research currently lacks a common conceptual framework, and one challenge in establishing it is the fact that aging is a highly complex process. To help develop a framework of standard…
10-25-2021
Aging-US published " Helicobacter pylori infection and risk for developing dementia: an evidence-based meta-analysis of case-control and cohort studies " which reported that infection with multiple pathogens may play a key role in the pathogenesis of dementia. Whether Helicobacter pylori infection is associated…
10-25-2021
Aging-US published " Melatonin inhibits proliferation, migration, and invasion by inducing ROS-mediated apoptosis via suppression of the PI3K/Akt/mTOR signaling pathway in gallbladder cancer cells " which reported that melatonin is an indolic compound mainly secreted by the pineal gland and plays a vital role in the…
10-25-2021
Aging-US published " Development of infrastructure for a systemic multidisciplinary approach to study aging in retired sled dogs " which reported that canines represent a valuable model for mammalian aging studies as large animals with short lifespans, allowing longitudinal analyses within a reasonable time frame.…
10-25-2021
Aging-US published " Iron: an underrated factor in aging " which reported that iron is an essential element for virtually all living organisms, but its reactivity also makes it potentially harmful. Blocking iron absorption through drugs or natural products extends lifespan. Dr. Dennis Mangan from MTOR LLC in…
10-25-2021
Aging-US published " Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition " which reported that green tea catechins are associated with a delay in aging. The authors have designed the current study to investigate the impact and to unveil the target of the…
09-21-2021
Aging-US published " The interplay between gray matter and white matter neurodegeneration in subjective cognitive decline " which reported that subjective cognitive complaints were assessed through 9 questions covering amnestic and non-amnestic cognitive domains. In these author’s cohort, 123 individuals endorsed from…
09-21-2021
Aging-US published " Reduced uremic metabolites are prominent feature of sarcopenia, distinct from antioxidative markers for frailty " which reported that due to global aging, frailty and sarcopenia are increasing. Sarcopenia is defined as loss of volume and strength of skeletal muscle in elderlies, while frailty…
09-21-2021
Aging-US published " Proteomic characterization of secretory granules in dopaminergic neurons indicates chromogranin/secretogranin-mediated protein processing impairment in Parkinson’s disease " which reported that the number of SGs in tyrosine hydroxylase-positive neurons and the marker proteins secretogranin III…
09-21-2021
Aging-US published " N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions " which reported that the authors systematically investigated the molecular alterations of m6A regulators and their clinical relevance with cognitive dysfunctions using published datasets of Alzheimer's…
09-21-2021
Aging-US published " Senescence-associated hyper-activation to inflammatory stimuli in vitro " which reported that aging is associated with an increased susceptibility to adverse inflammatory conditions such as sepsis and cytokine storm. To test this hypothesis, the authors examined the expression of various…
09-21-2021
Aging-US published " The role of age at menarche and age at menopause in Alzheimer’s disease: evidence from a bidirectional mendelian randomization study " which reported that the association between endogenous estrogen exposure and Alzheimer’s disease remains inconclusive in previous observational studies, and few…
09-21-2021
Aging-US published " Cellular senescence in lymphoid organs and immunosenescence " which reported that immunosenescence is a multi-faceted phenomenon at the root of age-associated immune dysfunction. Though both cellular senescence and immunosenescence have been studied extensively and implicated in various…