Volume 15, Issue 1

January 15, 2023pp 1—289

About the Cover

The cover features Figure 1 "t-SNE visualization of 14,588 old and young peripheral blood cells" from Teo et al.

Editorials

The complex determinants of Alzheimer’s-type dementias

Bruce M. Cohen, Kai-Christian Sonntag

https://doi.org/10.18632/aging.204478pp 1—3

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Applications of Alzheimer’s disease staging to clinical trials

Joseph Therriault, Serge Gauthier, Pedro Rosa-Neto

https://doi.org/10.18632/aging.204482pp 4—5

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Research Papers

Single-cell transcriptomics of peripheral blood in the aging mouse

Yee Voan Teo, Samuel J. Hinthorn, Ashley E. Webb, Nicola Neretti

https://doi.org/10.18632/aging.204471pp 6—20

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The innate immune signaling component FBXC-58 mediates dietary restriction effects on healthy aging in Caenorhabditis elegans

Jeong-Hoon Hahm, Farida S. Nirmala, Pyeong Geun Choi, Hyo-Deok Seo, Tae Youl Ha, Chang Hwa Jung, Jiyun Ahn

https://doi.org/10.18632/aging.204477pp 21—36

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Genetic deficiency and pharmacological modulation of RORα regulate laser-induced choroidal neovascularization

Chi-Hsiu Liu, Felix Yemanyi, Kiran Bora, Neetu Kushwah, Alexandra K. Blomfield, Theodore M. Kamenecka, John Paul SanGiovanni, Ye Sun, Laura A. Solt, Jing Chen

https://doi.org/10.18632/aging.204480pp 37—52

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miR-6742-5p regulates the invasion and migration of lung adenocarcinoma cells via mediating FGF8/ERK12/MMP9/MMP2 signaling pathway

Minglei Song, Xiaoying Xing

https://doi.org/10.18632/aging.204277pp 53—69

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Histone methyltransferase Smyd2 drives vascular aging by its enhancer-dependent activity

Zhenghua Su, Haibi Su, Jie Xu, Gang Wei, Lefeng Qu, Ting Ni, Di Yang, Yizhun Zhu

https://doi.org/10.18632/aging.204449pp 70—91

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Comprehensive bioinformatics analysis reveals the significance of forkhead box family members in pancreatic adenocarcinoma

Wei Hu, Mingxu Li, Yan Wang, Chengcheng Zhong, Xinxin Si, Xiao Shi, Zhong Wang

https://doi.org/10.18632/aging.204455pp 92—107

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Association between Apolipoprotein E genotype and functional outcome in acute ischemic stroke

Xiaoming Rong, Jingjuan Chen, Dong Pan, YuKai Wang, Chengguo Zhang, Yamei Tang

https://doi.org/10.18632/aging.204460pp 108—118

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Profiling of a novel circadian clock-related prognostic signature and its role in immune function and response to molecular targeted therapy in pancreatic cancer

Yu Jin, Shuang Gong, Guochen Shang, Lilin Hu, Gangping Li

https://doi.org/10.18632/aging.204462pp 119—133

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A case-control study coupling with meta-analysis elaborates decisive association between IGF-1 rs35767 and osteoporosis in Asian postmenopausal females

Sui-Lung Su, Yung-Hsun Huang, Yu-Hsuan Chen, Pi-Shao Ko, Wen Su, Chih-Chien Wang, Meng-Chang Lee

https://doi.org/10.18632/aging.204464pp 134—147

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Investigation on the mechanism of Shaoyao-Gancao Decoction in the treatment of gastric carcinoma based on network pharmacology and experimental verification

Xin Zhou, Jiao Min, Mengying Che, Yating Yang, Yi Yang, Junfei Zhang, Lei Zhang, Xiaosha Zheng, Yan Chen, Ling Yuan, Yi Nan

https://doi.org/10.18632/aging.204465pp 148—163

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Doxorubicin induced ROS-dependent HIF1α activation mediates blockage of IGF1R survival signaling by IGFBP3 promotes cardiac apoptosis

Su-Ying Wen, Ayaz Ali, I-Chieh Huang, Jian-Sheng Liu, Po-Yuan Chen, Vijaya Padma Viswanadha, Chih-Yang Huang, Wei-Wen Kuo

https://doi.org/10.18632/aging.204466pp 164—178

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lncRNA HCG11 suppresses cell proliferation in hormone receptor-positive breast cancer via SRSF1/β-catenin

Dan Xie, Saiyang Li, Xuehui Wang, Lin Fang

https://doi.org/10.18632/aging.204468pp 179—192

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A two-gene random forest model to diagnose osteoarthritis based on RNA-binding protein-related genes in knee cartilage tissue

Wenhua Yin, Ying Lei, Xuan Yang, Jiawei Zou

https://doi.org/10.18632/aging.204469pp 193—212

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Immune infiltration and immunophenotyping in atrial fibrillation

Yuqing Tian, Shiying Liu, Yanan Zhang, Jiefu Yang, Peiyao Guo, Hongchao Zhang, Xue Yu, Tong Zou

https://doi.org/10.18632/aging.204470pp 213—229

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Increased expression of GPX4 promotes the tumorigenesis of thyroid cancer by inhibiting ferroptosis and predicts poor clinical outcomes

Huanjie Chen, Fang Peng, Jingchao Xu, Guangzhi Wang, Yongfu Zhao

https://doi.org/10.18632/aging.204473pp 230—245

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Mitoquinone shifts energy metabolism to reduce ROS-induced oxeiptosis in female granulosa cells and mouse oocytes

Kuan-Hao Tsui, Chia-Jung Li

https://doi.org/10.18632/aging.204475pp 246—260

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The protective effect of luteolin on the depression-related dry eye disorder through Sirt1/NF-κB/NLRP3 pathway

Mingxia Xie, Hanqing Wang, Tiantian Gao, Jun Peng, Pan Meng, Xi Zhang, Dongwei Guo, Guangya Liu, Jian Shi, Qinghua Peng

https://doi.org/10.18632/aging.204479pp 261—275

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Effects of NBP on postoperative cognitive dysfunction in rats via Nrf 2/ARE pathway

Jianshuai He, Junqiong Gao, He Zhu, Yang Zhao, Xiaotian Zhang, Xiufang Wang, Shengnan Wan, Hongying Cao, Lin Zhai, Yuanyong Wang, Shilei Wang

https://doi.org/10.18632/aging.204481pp 276—286

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Corrections

Correction for: Endothelin-1-mediated miR-let-7g-5p triggers interlukin-6 and TNF-α to cause myopathy and chronic adipose inflammation in elderly patients with diabetes mellitus

Chung-Huang Tsai, Pei-Ju Huang, IT Lee, Chien-Min Chen, Min Huan Wu

https://doi.org/10.18632/aging.204488pp 287

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Correction for: Ganglioside GD1a enhances osteogenesis by activating ERK1/2 in mesenchymal stem cells of Lmna mutant mice

Dong Hoon Kwak, Ji Hye Park, Eul Sig Choi, Seong Hyun Park, Seo-Yeon Lee, Seoul Lee

https://doi.org/10.18632/aging.204489pp 288—289

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