Correction|Volume 15, Issue 1|pp 288—289

Correction for: Ganglioside GD1a enhances osteogenesis by activating ERK1/2 in mesenchymal stem cells of Lmna mutant mice

Dong Hoon Kwak^1,², Ji Hye Park^1,², Eul Sig Choi^1,², Seong Hyun Park^1,², Seo-Yeon Lee^1,², Seoul Lee^1,²

¹Department of Pharmacology, School of Medicine, Wonkwang University, Iksan, Jeollabuk-do 54538, Republic of Korea
²Brain Research Institute, Wonkwang University, Iksan, Jeollabuk-do 54538, Republic of Korea

Received: December 26, 2022Accepted: January 12, 2023Published: January 14, 2023

https://doi.org/10.18632/aging.204489

Copyright: © 2023 Kwak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

This article has been corrected: The authors found that Western blot images of p-ERK1/2 and ERK1/2 in Figure 4F were from different experiment with protein extracts from Lmna^Dhe/+mice. They replaced the incorrect images with the images of p-ERK1/2 and ERK1/2 in MSC protein extracts from normal and Lamin A/C knockdown (KD) mice. In Figure 4H, the authors corrected a typo where “p-ERK1/2” was mislabeled “p-REK1/2”. The authors also revised the Figure legend for Figure 4F and 4G as follows: “(F) Lamin A/C was knocked down in mouse MSCs using siRNA. (G) Primary MSCs with Lmna^Dhe/+ mutation were isolated from Lmna^Dhe/+ mice.” These corrections have no impact on the experimental outcome or conclusions.

Corrected Figure 4 legend and panels 4F and 4G presented below.

Figure 4.

Increases of osteogenesis and ERK1/2 activation in GD1a-treated Lmna dysfunction MSCs.… dysfunction MSCs. (F) Lamin A/C was knocked down in mouse MSCs using siRNA. (G) Primary MSCs with Lmna^Dhe/+ mutation were isolated from Lmna^Dhe/+ mice. (H) Phosphorylation of ERK1/2 in Lmna dysfunction MSCs treated with GD1a. (I)…. Phosphorylation of ERK1/2 was determined by western blotting with anti-p-ERK1/2. ERK1/2 was used as a loading control. Values represent mean ± SD; ^&&&p < 0.001 indicates a significant difference from the normal MSCs; ***p < 0.001 indicates a significant difference from the Lmna^Dhe/+ mutant MSCs; ^###p < 0.001 indicates a significant difference from the Lamin A/C KD MSCs. ^$$$p < 0.001 indicates a significant difference from the U0126-treated MSCs.