Volume 13, Issue 21

November 15, 2021pp 23872—24476

About the Cover

The cover features Figure 1 " Impaired mitochondrial homeostasis and motility defects in tau^wt-expressing 3-day adult animals“ from Palikaras et al.

Editorials

GWAS of canines identifies potential aging determinants

Timothy M. Robinette, Sergiy Libert

https://doi.org/10.18632/aging.203661pp 23872—23873

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Aging and brain connectivity by graph theory

Fabrizio Vecchio

https://doi.org/10.18632/aging.203680pp 23874—23875

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Priority Research Paper

Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy

Konstantinos Palikaras, Kavya Achanta, Seoyun Choi, Mansour Akbari, Vilhelm A. Bohr

https://doi.org/10.18632/aging.203683pp 23876—23894

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Research Papers

Role of tumor necrosis factor-α in the mortality of hospitalized patients with severe and critical COVID-19 pneumonia

Fang Jia, Gang Wang, Jing Xu, Junhong Long, Fuxue Deng, Wei Jiang

https://doi.org/10.18632/aging.203663pp 23895—23912

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New tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatment

Zhao Tianyu, Cui Xiaoli, Wang Yaru, Zhang Min, Yue Fengli, He Kan, Chen Li, Li Jing

https://doi.org/10.18632/aging.203666pp 23913—23935

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Impaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance

Karel M. Lopez-Vilaret, Jose L. Cantero, Marina Fernandez-Alvarez, Miguel Calero, Olga Calero, Mónica Lindín, Montserrat Zurrón, Fernando Díaz, Mercedes Atienza

https://doi.org/10.18632/aging.203668pp 23936—23952

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UBB⁺¹ reduces amyloid-β cytotoxicity by activation of autophagy in yeast

Xin Chen, Ana Joyce Muñoz-Arellano, Dina Petranovic

https://doi.org/10.18632/aging.203681pp 23953—23980

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Restoration of aged hematopoietic cells by their young counterparts through instructive microvesicles release

Steven J. Greco, Seda Ayer, Khadidiatou Guiro, Garima Sinha, Robert J. Donnelly, Markos H. El-Far, Lauren S. Sherman, Yannick Kenfack, Sri Harika Pamarthi, Marina Gergues, Oleta A. Sandiford, Michael J. Schonning, Jean-Pierre Etchegaray, Pranela Rameshwar

https://doi.org/10.18632/aging.203689pp 23981—24016

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Low-protein diet applied as part of combination therapy or stand-alone normalizes lifespan and tumor proliferation in a model of intestinal cancer

Alina Proske, Judith Bossen, Jakob von Frieling, Thomas Roeder

https://doi.org/10.18632/aging.203692pp 24017—24036

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MiRNA-30e downregulation increases cancer cell proliferation, invasion and tumor growth through targeting RPS6KB1

Lin Wang, Xiang-Bo Ji, Li-Hong Wang, Zhong-Kun Xia, Yun-Xia Xie, Wen-Jing Liu, Jian-Ge Qiu, Bing-Hua Jiang, Ling-Zhi Liu

https://doi.org/10.18632/aging.203665pp 24037—24049

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Identification of KIF4A as a prognostic biomarker for esophageal squamous cell carcinoma

Lingwei Wang, Gang Liu, Enkhbat Bolor-Erdene, Qinchuan Li, Yunqing Mei, Lei Zhou

https://doi.org/10.18632/aging.203585pp 24050—24070

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LncRNA MIR31HG is induced by tocilizumab and ameliorates rheumatoid arthritis fibroblast-like synoviocyte-mediated inflammation via miR-214-PTEN-AKT signaling pathway

Liang Cao, Haifeng Jiang, Jing Yang, Jun Mao, Guofeng Wei, Xiangyun Meng, Hongmei Zang

https://doi.org/10.18632/aging.203644pp 24071—24085

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Identification of the function and mechanism of m6A reader IGF2BP2 in Alzheimer’s disease

Yanyao Deng, Hongwei Zhu, Le Xiao, Chao Liu, Ya-Lin Liu, Wenzhe Gao

https://doi.org/10.18632/aging.203652pp 24086—24100

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Curcumol inhibits malignant biological behaviors and TMZ-resistance in glioma cells by inhibiting long noncoding RNA FOXD2-As1-promoted EZH2 activation

Xuyang Lv, Jiangchuan Sun, Linfeng Hu, Ying Qian, Chunlei Fan, Nan Tian

https://doi.org/10.18632/aging.203662pp 24101—24116

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Integrated analysis of expression, prognostic value and immune infiltration of GSDMs in hepatocellular carcinoma

Kuan Hu, Zhijie Xu, Lei Yao, Yuanliang Yan, Lei Zhou, Juanni Li

https://doi.org/10.18632/aging.203669pp 24117—24135

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Mutations in DNA damage response pathways as a potential biomarker for immune checkpoint blockade efficacy: evidence from a seven-cancer immunotherapy cohort

Wenjing Zhang, Liwen Zhang, Hao Jiang, Yuting Li, Suzhen Wang, Qinghua Wang

https://doi.org/10.18632/aging.203670pp 24136—24154

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Development of an immune-related signature for predicting survival outcome and immunotherapy response in osteosarcoma

Qinghua Wang, Wenjing Zhang, Yuxian Guo, Yuting Li, Kaifeng Fu

https://doi.org/10.18632/aging.203671pp 24155—24170

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LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability

Peng-Ping Li, Rong-Guo Li, Yu-Qing Huang, Jin-Pian Lu, Wei-Jun Zhang, Zhen-Yu Wang

https://doi.org/10.18632/aging.203672pp 24171—24191

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Association of frailty and chemotherapy-related adverse outcomes in geriatric patients with cancer: a pilot observational study in Taiwan

Ya-Wen Ho, Woung-Ru Tang, Shih-Ying Chen, Shu-Hui Lee, Jen-Shi Chen, Yu-Shin Hung, Wen-Chi Chou

https://doi.org/10.18632/aging.203673pp 24192—24204

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YTH domain family: potential prognostic targets and immune-associated biomarkers in hepatocellular carcinoma

Miaomiao Liu, Zijin Zhao, Yuan Cai, Peng Bi, Qiuju Liang, Yuanliang Yan, Zhijie Xu

https://doi.org/10.18632/aging.203674pp 24205—24218

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Construction and external validation of a 5-gene random forest model to diagnose non-obstructive azoospermia based on the single-cell RNA sequencing of testicular tissue

Ranran Zhou, Xianyuan Lv, Tianle Chen, Qi Chen, Hu Tian, Cheng Yang, Wenbin Guo, Cundong Liu

https://doi.org/10.18632/aging.203675pp 24219—24235

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The first central precocious puberty proteomic profiles revealed multiple metabolic networks and novel key disease-associated proteins

Chunlin Wang, Qingqing Chen, Ke Yuan, Minfei He, Jianfang Zhu, Yanlan Fang, Jianhong Hu, Qingfeng Yan

https://doi.org/10.18632/aging.203676pp 24236—24250

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A prognostic fibroblast-related risk signature in colorectal cancer

Hao Xu, Yisheng Pan

https://doi.org/10.18632/aging.203677pp 24251—24270

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Immunological and clinical immunotherapy implications of NLRP3 mutations in melanoma

Qinghua Wang, Juncheng Lyu, Wenjing Zhang, Fuyan Shi, Yanfeng Ren, Qian Mao, Yujie Liu, Yuting Li, Suzhen Wang

https://doi.org/10.18632/aging.203678pp 24271—24289

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Decoding the chemical composition and pharmacological mechanisms of Jiedu Tongluo Tiaogan Formula using high-performance liquid chromatography coupled with network pharmacology-based investigation

Qi Zhang, Chunli Piao, Wenqi Jin, De Jin, Han Wang, Cheng Tang, Xiaohua Zhao, Naiwen Zhang, Shengnan Gao, Fengmei Lian

https://doi.org/10.18632/aging.203679pp 24290—24312

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Establishment of a tumor immune microenvironment-based molecular classification system of breast cancer for immunotherapy

Xiaobo Zheng, Li Li, Chune Yu, Jiqiao Yang, Yujie Zhao, Chao Su, Jing Yu, Mingqing Xu

https://doi.org/10.18632/aging.203682pp 24313—24338

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Deletion of miR-15a inhibited glioma development via targeting Smad7 and inhibiting EMT pathway

Yanfeng Guo, Xiaopeng Gao, Shien An, Xin Li, Lekun Pan, Hongyan Liu, Jixiang Liu, Jianzhou Gao, Zhihuang Zhao, Gang Li, Yonggang Han, Yabin Li, Zhisheng Ji

https://doi.org/10.18632/aging.203684pp 24339—24348

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