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The cover features Figure 1 " Impaired mitochondrial homeostasis and motility defects in tauwt-expressing 3-day adult animals“ from Palikaras et al.

Volume 13, Issue 21

15 November, 2021
pp 23872—24476

About the Cover

The cover features Figure 1 " Impaired mitochondrial homeostasis and motility defects in tauwt-expressing 3-day adult animals“ from Palikaras et al.


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Editorials

GWAS of canines identifies potential aging determinants

Timothy M. Robinette, Sergiy Libert,
https://doi.org/10.18632/aging.203661 pp 23872—23873
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Aging and brain connectivity by graph theory

Fabrizio Vecchio,
https://doi.org/10.18632/aging.203680 pp 23874—23875
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Priority Research Paper

Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy

Konstantinos Palikaras, Kavya Achanta, Seoyun Choi, Mansour Akbari, Vilhelm A. Bohr,
https://doi.org/10.18632/aging.203683 pp 23876—23894
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Research Papers

COVID-19
Role of tumor necrosis factor-α in the mortality of hospitalized patients with severe and critical COVID-19 pneumonia

Fang Jia, Gang Wang, Jing Xu, Junhong Long, Fuxue Deng, Wei Jiang,
https://doi.org/10.18632/aging.203663 pp 23895—23912
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COVID-19
New tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatment

Zhao Tianyu, Cui Xiaoli, Wang Yaru, Zhang Min, Yue Fengli, He Kan, Chen Li, Li Jing,
https://doi.org/10.18632/aging.203666 pp 23913—23935
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Impaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance

Karel M. Lopez-Vilaret, Jose L. Cantero, Marina Fernandez-Alvarez, Miguel Calero, Olga Calero, Mónica Lindín, Montserrat Zurrón, Fernando Díaz, Mercedes Atienza,
https://doi.org/10.18632/aging.203668 pp 23936—23952
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UBB+1 reduces amyloid-β cytotoxicity by activation of autophagy in yeast

Xin Chen, Ana Joyce Muñoz-Arellano, Dina Petranovic,
https://doi.org/10.18632/aging.203681 pp 23953—23980
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Restoration of aged hematopoietic cells by their young counterparts through instructive microvesicles release

Steven J. Greco, Seda Ayer, Khadidiatou Guiro, Garima Sinha, Robert J. Donnelly, Markos H. El-Far, Lauren S. Sherman, Yannick Kenfack, Sri Harika Pamarthi, Marina Gergues, Oleta A. Sandiford, Michael J. Schonning, Jean-Pierre Etchegaray, Pranela Rameshwar,
https://doi.org/10.18632/aging.203689 pp 23981—24016
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Low-protein diet applied as part of combination therapy or stand-alone normalizes lifespan and tumor proliferation in a model of intestinal cancer

Alina Proske, Judith Bossen, Jakob von Frieling, Thomas Roeder,
https://doi.org/10.18632/aging.203692 pp 24017—24036
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MiRNA-30e downregulation increases cancer cell proliferation, invasion and tumor growth through targeting RPS6KB1

Lin Wang, Xiang-Bo Ji, Li-Hong Wang, Zhong-Kun Xia, Yun-Xia Xie, Wen-Jing Liu, Jian-Ge Qiu, Bing-Hua Jiang, Ling-Zhi Liu,
https://doi.org/10.18632/aging.203665 pp 24037—24049
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Identification of KIF4A as a prognostic biomarker for esophageal squamous cell carcinoma

Lingwei Wang, Gang Liu, Enkhbat Bolor-Erdene, Qinchuan Li, Yunqing Mei, Lei Zhou,
https://doi.org/10.18632/aging.203585 pp 24050—24070
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LncRNA MIR31HG is induced by tocilizumab and ameliorates rheumatoid arthritis fibroblast-like synoviocyte-mediated inflammation via miR-214-PTEN-AKT signaling pathway

Liang Cao, Haifeng Jiang, Jing Yang, Jun Mao, Guofeng Wei, Xiangyun Meng, Hongmei Zang,
https://doi.org/10.18632/aging.203644 pp 24071—24085
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Identification of the function and mechanism of m6A reader IGF2BP2 in Alzheimer’s disease

Yanyao Deng, Hongwei Zhu, Le Xiao, Chao Liu, Ya-Lin Liu, Wenzhe Gao,
https://doi.org/10.18632/aging.203652 pp 24086—24100
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Curcumol inhibits malignant biological behaviors and TMZ-resistance in glioma cells by inhibiting long noncoding RNA FOXD2-As1-promoted EZH2 activation

Xuyang Lv, Jiangchuan Sun, Linfeng Hu, Ying Qian, Chunlei Fan, Nan Tian,
https://doi.org/10.18632/aging.203662 pp 24101—24116
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Integrated analysis of expression, prognostic value and immune infiltration of GSDMs in hepatocellular carcinoma

Kuan Hu, Zhijie Xu, Lei Yao, Yuanliang Yan, Lei Zhou, Juanni Li,
https://doi.org/10.18632/aging.203669 pp 24117—24135
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Mutations in DNA damage response pathways as a potential biomarker for immune checkpoint blockade efficacy: evidence from a seven-cancer immunotherapy cohort

Wenjing Zhang, Liwen Zhang, Hao Jiang, Yuting Li, Suzhen Wang, Qinghua Wang,
https://doi.org/10.18632/aging.203670 pp 24136—24154
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Development of an immune-related signature for predicting survival outcome and immunotherapy response in osteosarcoma

Qinghua Wang, Wenjing Zhang, Yuxian Guo, Yuting Li, Kaifeng Fu,
https://doi.org/10.18632/aging.203671 pp 24155—24170
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LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability

Peng-Ping Li, Rong-Guo Li, Yu-Qing Huang, Jin-Pian Lu, Wei-Jun Zhang, Zhen-Yu Wang,
https://doi.org/10.18632/aging.203672 pp 24171—24191
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Association of frailty and chemotherapy-related adverse outcomes in geriatric patients with cancer: a pilot observational study in Taiwan

Ya-Wen Ho, Woung-Ru Tang, Shih-Ying Chen, Shu-Hui Lee, Jen-Shi Chen, Yu-Shin Hung, Wen-Chi Chou,
https://doi.org/10.18632/aging.203673 pp 24192—24204
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YTH domain family: potential prognostic targets and immune-associated biomarkers in hepatocellular carcinoma

Miaomiao Liu, Zijin Zhao, Yuan Cai, Peng Bi, Qiuju Liang, Yuanliang Yan, Zhijie Xu,
https://doi.org/10.18632/aging.203674 pp 24205—24218
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Construction and external validation of a 5-gene random forest model to diagnose non-obstructive azoospermia based on the single-cell RNA sequencing of testicular tissue

Ranran Zhou, Xianyuan Lv, Tianle Chen, Qi Chen, Hu Tian, Cheng Yang, Wenbin Guo, Cundong Liu,
https://doi.org/10.18632/aging.203675 pp 24219—24235
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The first central precocious puberty proteomic profiles revealed multiple metabolic networks and novel key disease-associated proteins

Chunlin Wang, Qingqing Chen, Ke Yuan, Minfei He, Jianfang Zhu, Yanlan Fang, Jianhong Hu, Qingfeng Yan,
https://doi.org/10.18632/aging.203676 pp 24236—24250
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A prognostic fibroblast-related risk signature in colorectal cancer

Hao Xu, Yisheng Pan,
https://doi.org/10.18632/aging.203677 pp 24251—24270
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Immunological and clinical immunotherapy implications of NLRP3 mutations in melanoma

Qinghua Wang, Juncheng Lyu, Wenjing Zhang, Fuyan Shi, Yanfeng Ren, Qian Mao, Yujie Liu, Yuting Li, Suzhen Wang,
https://doi.org/10.18632/aging.203678 pp 24271—24289
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Decoding the chemical composition and pharmacological mechanisms of Jiedu Tongluo Tiaogan Formula using high-performance liquid chromatography coupled with network pharmacology-based investigation

Qi Zhang, Chunli Piao, Wenqi Jin, De Jin, Han Wang, Cheng Tang, Xiaohua Zhao, Naiwen Zhang, Shengnan Gao, Fengmei Lian,
https://doi.org/10.18632/aging.203679 pp 24290—24312
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Establishment of a tumor immune microenvironment-based molecular classification system of breast cancer for immunotherapy

Xiaobo Zheng, Li Li, Chune Yu, Jiqiao Yang, Yujie Zhao, Chao Su, Jing Yu, Mingqing Xu,
https://doi.org/10.18632/aging.203682 pp 24313—24338
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Deletion of miR-15a inhibited glioma development via targeting Smad7 and inhibiting EMT pathway

Yanfeng Guo, Xiaopeng Gao, Shien An, Xin Li, Lekun Pan, Hongyan Liu, Jixiang Liu, Jianzhou Gao, Zhihuang Zhao, Gang Li, Yonggang Han, Yabin Li, Zhisheng Ji,
https://doi.org/10.18632/aging.203684 pp 24339—24348
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A five-lncRNA model predicting overall survival in gastric cancer compared with normal tissues

Congbo Cai, Lei Yang, Xieyan Zhuang, Yi He, Kena Zhou,
https://doi.org/10.18632/aging.203685 pp 24349—24359
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Polymorphisms in lncRNA MIR2052HG and susceptibility to breast cancer in Chinese population

Hui Yang, Qiuyu Sun, Feifei Chong, Xiaoru Jiang, Yanli Wang, Kedi Xu, Yuanlin Zou, Linping Xu, Chunhua Song,
https://doi.org/10.18632/aging.203686 pp 24360—24378
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Pyroptosis-related gene mediated modification patterns and immune cell infiltration landscapes in cutaneous melanoma to aid immunotherapy

Jinzhi Meng, Xing Huang, Yue Qiu, Xifan Zheng, Junpu Huang, Zhenpei Wen, Jun Yao,
https://doi.org/10.18632/aging.203687 pp 24379—24401
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miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer

Hui Liu, Yuan Xiang, Qi-Bei Zong, Xiao-Yu Zhang, Zhi-Wen Wang, Shi-Qiang Fang, Tong-Cun Zhang, Xing-Hua Liao,
https://doi.org/10.18632/aging.203688 pp 24402—24416
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RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling

Na He, Yu-Juan Qu, Dan-Yang Li, Shou-Wei Yue,
https://doi.org/10.18632/aging.203691 pp 24417—24431
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Immune cell and TCR/BCR repertoire profiling in systemic lupus erythematosus patients by single-cell sequencing

Fengping Zheng, Huixuan Xu, Cantong Zhang, Xiaoping Hong, Dongzhou Liu, Donge Tang, Zuying Xiong, Yong Dai,
https://doi.org/10.18632/aging.203695 pp 24432—24448
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Small interfering RNA-induced silencing lncRNA PVT1 inhibits atherosclerosis via inactivating the MAPK/NF-κB pathway

Hong Du, Hui Zhang, Rong Yang, Li Qiao, Huiyu Shao, Xiaolin Zhang,
https://doi.org/10.18632/aging.203696 pp 24449—24463
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Propofol suppresses the growth and invasion of cervical carcinoma cells by inhibiting MIR155HG

Xin-Tan Du, Xiao-Yan Wang, Ying-He Zheng, Da-Peng Liu,
https://doi.org/10.18632/aging.203697 pp 24464—24475
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Correction

Correction for: Decreased gray matter volume and increased white matter volume in patients with neovascular age-related macular degeneration: a voxel-based morphometry study

Yan-Kun Shen, Qian-Min Ge, Yi-Cong Pan, Hui-Ye Shu, Li-Juan Zhang, Qiu-Yu Li, Rong-Bin Liang, Yi Shao, Yao Yu,
https://doi.org/10.18632/aging.203702 pp 24476
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