Volume 13, Issue 22

November 30, 2021pp 24477—24916

About the Cover

The cover features Figure 6 "3D scatter plot of the covariates influencing CaAKG treatment efficacy“ from Demidenko et al.

Editorials

Twists and turns in Kras-driven tumor initiation

Yoshiaki Maru, Yoshitaka Hippo

https://doi.org/10.18632/aging.203726pp 24477—24479

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Early elevation of BACE1 in dementia

Carlo Cervellati, Giuseppe Valacchi, Giovanni Zuliani

https://doi.org/10.18632/aging.203727pp 24480—24481

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Cellular resilience and baboon aging

Daniel A. Adekunbi, Peter W. Nathanielsz, Adam B. Salmon

https://doi.org/10.18632/aging.203728pp 24482—24484

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Priority Research Paper

Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test

Oleksandr Demidenko, Diogo Barardo, Valery Budovskii, Robb Finnemore, Francis R. Palmer III, Brian K. Kennedy, Yelena V. Budovskaya

https://doi.org/10.18632/aging.203736pp 24485—24499

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Research Papers

The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial

Yafit Hachmo, Amir Hadanny, Sonia Mendelovic, Pnina Hillman, Eyal Shapira, Geva Landau, Hadar Gattegno, Avi Zrachya, Malka Daniel-Kotovsky, Merav Catalogna, Gregory Fishlev, Erez Lang, Nir Polak, Keren Doenyas, Mony Friedman, Yonatan Zemel, Yair Bechor, Shai Efrati

https://doi.org/10.18632/aging.203701pp 24500—24510

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Hyperbaric oxygen therapy induces transcriptome changes in elderly: a prospective trial

Amir Hadanny, Relly Forer, Dina Volodarsky, Malka Daniel-Kotovsky, Merav Catalogna, Yonatan Zemel, Yair Bechor, Shai Efrati

https://doi.org/10.18632/aging.203709pp 24511—24523

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Progressive reorganization of mitochondrial apparatus in aging skeletal muscle of naked mole rats (Heterocephalus glaber) as revealed by electron microscopy: potential role in continual maintenance of muscle activity

Valeriya Vays, Irina Vangely, Chupalav Eldarov, Susanne Holtze, Thomas Hildebrandt, Lora Bakeeva, Vladimir Skulachev

https://doi.org/10.18632/aging.203720pp 24524—24541

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Increased proliferation and differentiation capacity of placenta-derived mesenchymal stem cells from women of median maternal age correlates with telomere shortening

Erika N. Guerrero, Shantal Vega, Cindy Fu, Ruth De León, Davis Beltran, Mairim Alexandra Solis

https://doi.org/10.18632/aging.203724pp 24542—24559

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Circular RNA CELF1 drives immunosuppression and anti-PD1 therapy resistance in non-small cell lung cancer via the miR-491-5p/EGFR axis

Wen Ge, Hao Chi, Hua Tang, Jianjun Xu, Jing Wang, Wan Cai, Haitao Ma

https://doi.org/10.18632/aging.203576pp 24560—24579

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BMPR2 promoter methylation and its expression in valvular heart disease complicated with pulmonary artery hypertension

Ni Li, Linwen Zhu, Caimin Zhu, Hua Zhou, Dawei Zheng, Guodong Xu, Huoshun Shi, Jianqing Gao, Albert Jiarui Li, Zhaoyang Wang, Lebo Sun, Xiajun Li, Guofeng Shao

https://doi.org/10.18632/aging.203690pp 24580—24604

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Knockdown of transient receptor potential melastatin 2 reduces renal fibrosis and inflammation by blocking transforming growth factor-β1-activated JNK1 activation in diabetic mice

Feng Hu, Yun Yu, Feng Lu, Xiaoshu Cheng

https://doi.org/10.18632/aging.203694pp 24605—24620

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Construction of a genome instability-derived lncRNA-based risk scoring system for the prognosis of hepatocellular carcinoma

Dan-Ping Huang, Mian-Mian Liao, Jing-Jing Tong, Wei-Qu Yuan, De-Ti Peng, Jian-Ping Lai, Yi-Hao Zeng, Yi-Jun Qiu, Guang-Dong Tong

https://doi.org/10.18632/aging.203698pp 24621—24639

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PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway

Haocong Zhang, Dulei Xiang, Xinwei Liu, Liangbi Xiang

https://doi.org/10.18632/aging.203699pp 24640—24654

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Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis

Xiaolin Ni, Chen Bai, Chao Nie, Liping Qi, Yifang Liu, Huiping Yuan, Xiaoquan Zhu, Liang Sun, Qi Zhou, Yan Li, Hefu Zhen, Huabing Su, Rongqiao Li, Rushu Lan, Guofang Pang, Yuan Lv, Wei Zhang, Fan Yang, Yao Yao, Chen Chen, Zhaoping Wang, Danni Gao, Nan Zhang, Shenqi Zhang, Li Zhang, Zhu Wu, Caiyou Hu, Yi Zeng, Ze Yang

https://doi.org/10.18632/aging.203700pp 24655—24674

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BMAL1 may be involved in angiogenesis and peritumoral cerebral edema of human glioma by regulating VEGF and ANG2

Fan Wang, CaiYan Li, Fei Han, LvAn Chen, Ling Zhu

https://doi.org/10.18632/aging.203708pp 24675—24685

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Genomic mutation features identify distinct BRCA-associated mutation characteristics in endometrioid carcinoma and endometrioid ovarian carcinoma

Canhui Cao, Ruidi Yu, Wenjian Gong, Dan Liu, Xiaoxue Zhang, Yong Fang, Yu Xia, Wei Zhang, Qinglei Gao

https://doi.org/10.18632/aging.203710pp 24686—24709

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Detection of genomic structure variants associated with wrinkled skin in Xiang pig by next generation sequencing

Liu Xiaoli, Hu Fengbin, Huang Shihui, Niu Xi, Li Sheng, Wang Zhou, Ran Xueqin, Wang Jiafu

https://doi.org/10.18632/aging.203711pp 24710—24739

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Inhibition of Fam114A1 protects melanocytes from apoptosis through higher RACK1 expression

Miaoni Zhou, Fuquan Lin, Xingang Wu, Zhuyi Ping, Wen Xu, Rong Jin, Aie Xu

https://doi.org/10.18632/aging.203712pp 24740—24752

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Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling

Yanyi Xiao, Yilong Liu, Zhiwei Gao, Xian Li, Min Weng, Chenghao Shi, Cheng Wang, Linxiao Sun

https://doi.org/10.18632/aging.203713pp 24753—24767

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Tumor purity as a prognosis and immunotherapy relevant feature in cervical cancer

Yali Deng, Zewen Song, Li Huang, Zhenni Guo, Binghua Tong, Meiqing Sun, Jin Zhao, Huina Zhang, Zhen Zhang, Guoyin Li

https://doi.org/10.18632/aging.203714pp 24768—24785

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Excluding embryos with two novel mutations in FREM2 gene by the next-generation sequencing-based single nucleotide polymorphism haplotyping

Yao Zhou, Xiaohui Yang, Zheng Liu, Yu Zhang, Huaye Chen, Yongfang Zhang, Yuxin Hu, Yanlin Ma, Qi Li

https://doi.org/10.18632/aging.203715pp 24786—24794

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Identification of pyroptosis-related signature for cervical cancer predicting prognosis

Cankun Zhou, Chaomei Li, Yuhua Zheng, Xiaochun Liu

https://doi.org/10.18632/aging.203716pp 24795—24814

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Atorvastatin combined with dexamethasone promote hematoma absorption in an optimized rat model of chronic subdural hematoma

Dong Wang, Yueshan Fan, Jun Ma, Chuang Gao, Xuanhui Liu, Zilong Zhao, Huijie Wei, Guili Yang, Jinhao Huang, Rongcai Jiang, Jianning Zhang

https://doi.org/10.18632/aging.203717pp 24815—24828

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Bone morphogenetic protein 9 enhances osteogenic and angiogenic responses of human amniotic mesenchymal stem cells cocultured with umbilical vein endothelial cells through the PI3K/AKT/m-TOR signaling pathway

Ziming Liu, Yuwan Li, Jianye Yang, Jiaxing Huang, Changqi Luo, Jun Zhang, Wenqiang Yan, Yingfang Ao

https://doi.org/10.18632/aging.203718pp 24829—24849

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Long noncoding RNA NEAT1 inhibits the acetylation of PTEN through the miR-524-5p /HDAC1 axis to promote the proliferation and invasion of laryngeal cancer cells

Jiajia Zhang, Ping Wang, Yanli Cui

https://doi.org/10.18632/aging.203719pp 24850—24865

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A scoring model based on ferroptosis genes for prognosis and immunotherapy response prediction and tumor microenvironment evaluation in liver hepatocellular carcinoma

Lei Gao, Juan Xue, Xiaomin Liu, Lei Cao, Ruifang Wang, Liangliang Lei

https://doi.org/10.18632/aging.203721pp 24866—24881

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Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients

Do Thi Minh Xuan, Chung-Che Wu, Tzu-Jen Kao, Hoang Dang Khoa Ta, Gangga Anuraga, Vivin Andriani, Muhammad Athoillah, Chung-Chieh Chiao, Yung-Fu Wu, Kuen-Haur Lee, Chih-Yang Wang, Jian-Ying Chuang

https://doi.org/10.18632/aging.203722pp 24882—24913

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