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Research Paper|Volume 13, Issue 21|pp 24236—24250

The first central precocious puberty proteomic profiles revealed multiple metabolic networks and novel key disease-associated proteins

Chunlin Wang1, Qingqing Chen1, Ke Yuan1, Minfei He1, Jianfang Zhu1, Yanlan Fang1, Jianhong Hu2, Qingfeng Yan1,3
  • 1Department of Pediatrics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
  • 2Hailiang Hospital, Zhuji, Zhejiang Province, China
  • 3College of Life Science, Zhejiang University, Hangzhou, Zhejiang Province, China
Received: September 7, 2021Accepted: October 28, 2021Published: November 8, 2021
https://doi.org/10.18632/aging.203676

Copyright: © 2021 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Though central precocious puberty (CPP) as a disease that seriously affects the development of a child is increasing year by year, treatment options remain limited and is the same as the 1980s’ method. These are mainly due to the complex pathogenesis of central precocious puberty. Therefore, systems biology approach to identify and explore the multiple factors related to the pathogenesis of central precocious puberty is necessary. Our data established the first proteome profile of CPP revealed 163 down-regulated and 129 were up-regulated differentially expressed proteins. These altered proteins were primarily enriched in three metabolic process including energy metabolism, amino acid metabolism and nitrogenous base metabolism. The identified altered members of the metabolic signaling are valuable and potential novel therapeutic targets of central precocious puberty.