Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 16, Issue 9

15 May, 2024
pp 7508—8399

About the Cover

The cover features Figure 4 " Timeline of human embryogenesis showing the developmental stages and the emergence of different features of life" from Loseva and Gladyshev

Explore This Issue

Editorial

Stopping the aged brain from eating itself

Mar Puigdellívol, Guy C. Brown,

https://doi.org/10.18632/aging.205887 pp 7508—7510

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Research Papers

Germicidal lamps using UV-C radiation may pose health safety issues: a biomolecular analysis of their effects on apoptosis and senescence

Nicola Alessio, Alessia Ambrosino, Andrea Boggi, Domenico Aprile, Iole Pinto, Giovanni Galano, Umberto Galderisi, Giovanni Di Bernardo,

https://doi.org/10.18632/aging.205787 pp 7511—7522

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Cell type-dependent modulation of senescence features using Weo electrolyzed water

Brenda L. Court-Vazquez, Shirley A. Arroyo-Vizcarrondo, Jonathan A. Poli, Lara Nyman, Kelly Halderman, Anthony Ginter, Pierre-Yves Desprez,

https://doi.org/10.18632/aging.205789 pp 7523—7534

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Caloric restriction mitigates age-associated senescence characteristics in subcutaneous adipose tissue-derived stem cells

Somaiah Chinnapaka, Hamid Malekzadeh, Zayaan Tirmizi, Asim Ejaz,

https://doi.org/10.18632/aging.205812 pp 7535—7552

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Biological sex, sex steroids and sex chromosomes contribute to mouse cardiac aging

Audrey Morin-Grandmont, Élisabeth Walsh-Wilkinson, Emylie-Ann Labbé, Sara-Ève Thibodeau, Élizabeth Dupont, Dominique K. Boudreau, Marie Arsenault, Yohan Bossé, Jacques Couet,

https://doi.org/10.18632/aging.205822 pp 7553—7577

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Establishment and verification of a prognostic model based on coagulation and fibrinolysis-related genes in hepatocellular carcinoma

Meng Fan, Le Lu, Hao Shang, Yuxuan Lu, Yi Yang, Xiuyan Wang, Hongwei Lu,

https://doi.org/10.18632/aging.205699 pp 7578—7595

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Investigating gene signatures associated with immunity in colon adenocarcinoma to predict the immunotherapy effectiveness using NFM and WGCNA algorithms

Weizheng Liang, Xiangyu Yang, Xiushen Li, Peng Wang, Zhenpeng Zhu, Shan Liu, Dandan Xu, Xuejun Zhi, Jun Xue,

https://doi.org/10.18632/aging.205763 pp 7596—7621

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Construction of exosome-related genes risk model in kidney cell carcinoma predicts prognosis and immune therapy response

Chao Gao, Wei Huang, Qiang Su, Jingxian Li, Wei Wang, Yuanjiong Qi, E Du, Zhihong Zhang,

https://doi.org/10.18632/aging.205767 pp 7622—7646

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GJB3: a comprehensive biomarker in pan-cancer prognosis and immunotherapy prediction

Jingtong Zeng, Xianjie Li, Yifan Zhang, Bo Zhang, Hanqing Wang, Shihao Bao, Lingling Zu, Hao Zhang, Yuan Cheng, Quanying Tang, Xiaohong Xu, Song Xu, Zuoqing Song,

https://doi.org/10.18632/aging.205774 pp 7647—7667

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Causal association of metformin treatment with diverse cardiovascular diseases: a Mendelian randomization analysis

Kaiyuan Li, Peng Liu, Jun Ye, Miao Liu, Li Zhu,

https://doi.org/10.18632/aging.205775 pp 7668—7682

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Iron retardation in lysosomes protects senescent cells from ferroptosis

Yujing Feng, Huaiqing Wei, Meng Lyu, Zhiyuan Yu, Jia Chen, Xinxing Lyu, Fengfeng Zhuang,

https://doi.org/10.18632/aging.205777 pp 7683—7703

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Immune cell senescence and exhaustion promote the occurrence of liver metastasis in colorectal cancer by regulating epithelial-mesenchymal transition

Sen Lin, Lanyue Ma, Jiaxin Mo, Ruiqi Zhao, Jinghao Li, Mengjiao Yu, Mei Jiang, Lisheng Peng,

https://doi.org/10.18632/aging.205778 pp 7704—7732

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A real-world study was conducted to develop a nomogram that predicts the occurrence of anastomotic leakage in patients with esophageal cancer following esophagectomy

Chenglin Li, Wei Song, Jialing Zhang, Zhongneng Xu, Yonggang Luo,

https://doi.org/10.18632/aging.205780 pp 7733—7751

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Long non-coding RNA HOTAIR: from pan-cancer analysis to colorectal cancer-related uridine metabolism

Xuyu Chen, Siying Wang, Xin Jiang, Min Zhang, Yanbing Ding,

https://doi.org/10.18632/aging.205781 pp 7752—7773

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The identification of a N⁶-methyladenosin-modifed immune pattern to predict immunotherapy response and survival in urothelial carcinoma

Xudong Mao, Xianjiong Chen, Zhehao Xu, Lifeng Ding, Wenqin Luo, Yudong Lin, Ruyue Wang, Liqun Xia, Mingchao Wang, Gonghui Li,

https://doi.org/10.18632/aging.205782 pp 7774—7798

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Identifying lncRNAs and mRNAs related to survival of NSCLC based on bioinformatic analysis and machine learning

Wei Yue, Jing Wang, Bo Lin, Yongping Fu,

https://doi.org/10.18632/aging.205783 pp 7799—7817

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Unraveling the unfolded protein response signature: implications for tumor immune microenvironment heterogeneity and clinical prognosis in stomach cancer

Wenhao Ouyang, Yajing Liu, Hong Huang, Yujing Tan, Zhenjun Huang, Xueyuan Jia, Yunfang Yu, Herui Yao,

https://doi.org/10.18632/aging.205784 pp 7818—7844

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Left ventricular systolic dysfunction predicts clinical prognosis in patients with acute ischemic stroke after intravenous thrombolysis

Chi Zhang, Jun-Cang Wu, Zheng Tan, Xiao-Lu He, Fei Li, Long Wang, Yu Wang,

https://doi.org/10.18632/aging.205786 pp 7845—7855

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Role of vitamin B12 and folic acid in treatment of Alzheimer’s disease: a meta-analysis of randomized control trials

Chih-Ying Lee, Lung Chan, Chaur-Jong Hu, Chien-Tai Hong, Jia-Hung Chen,

https://doi.org/10.18632/aging.205788 pp 7856—7869

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Leptin attenuates the osteogenic induction potential of BMP9 by increasing β-catenin malonylation modification via Sirt5 down-regulation

Kai-Xin Ke, Xiang Gao, Lu Liu, Wen-Ge He, Yue Jiang, Cheng-Bin Long, Gan Zhong, Zheng-Hao Xu, Zhong-Liang Deng, Bai-Cheng He, Ning Hu,

https://doi.org/10.18632/aging.205790 pp 7870—7888

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Predictive value of FCGBP expression for treatment response and survival in rectal cancer patients undergoing chemoradiotherapy

Yu-Ting Su, Chung-Hsing Chen, Jui-Wen Kang, Hsin-Yu Kuo, Ching-Chieh Yang, Yu-Feng Tian, Cheng-Fa Yeh, Chia-Lin Chou, Shang-Hung Chen,

https://doi.org/10.18632/aging.205791 pp 7889—7901

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Improvement of skin wound healing by giant salamander skin mucus gel wrapped with bone marrow mesenchymal stem cells via affecting integrin family molecules

Wei Li, Dayong Du, Yan Huang, Cui Xu, Yang Liu, Xiaohong Wu, Jie Yang, Zhipeng Liu, Jianxin Ma, Chaoji Huangfu,

https://doi.org/10.18632/aging.205792 pp 7902—7914

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IL21 inhibits miR-361-5p to promote MAP3K9 and further aggravate the progression of shoulder arthritis

Kangning Hao, Pengchao Lin, Jing Li, Jie Hu, Jiangyong Wang, Fei Li,

https://doi.org/10.18632/aging.205793 pp 7915—7927

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Human umbilical cord mesenchymal stem cells promote steroid-induced osteonecrosis of the femoral head repair by improving microvascular endothelial cell function

Junwen Chen, Wenyi Jin, Changheng Zhong, Wenxiang Cai, Liangkun Huang, Jianlin Zhou, Hao Peng,

https://doi.org/10.18632/aging.205794 pp 7928—7945

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Trigeminal nerve electrical stimulation attenuates early traumatic brain injury through the TLR4/NF-κB/NLRP3 signaling pathway mediated by orexin-A/OX1R system

Junwei Kang, Yifan Zhou, Qi Xiong, Xiaoyang Dong,

https://doi.org/10.18632/aging.205795 pp 7946—7960

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Effects of butyrate on intestinal ischemia-reperfusion injury via the HMGB1-TLR4-MyD88 signaling pathway

Yuanyuan Rong, Meili Xu, Tao Hu, Shasha Zhang, Jianfeng Fu, Huaqin Liu,

https://doi.org/10.18632/aging.205797 pp 7961—7978

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Mechanistic exploration and experimental validation of the Xiaochaihu decoction for the treatment of breast cancer by network pharmacology

Qinglong Liu, Zehua Luo, Mei Sun, Wenjun Li, Songqing Liu,

https://doi.org/10.18632/aging.205798 pp 7979—7999

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A systematic pan-cancer analysis identifies LDHA as a novel predictor for immunological, prognostic, and immunotherapy resistance

Qiqi Zhang, Yuanning Luo, Bingshuo Qian, Xiuhua Cao, Caijun Xu, Kan Guo, Runlan Wan, Yaling Jiang, Tiecheng Wang, Zhiqiang Mei, Jinbiao Liu, Chaoxiang Lv,

https://doi.org/10.18632/aging.205800 pp 8000—8018

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AURKB promotes colorectal cancer progression by triggering the phosphorylation of histone H3 at serine 10 to activate CCNE1 expression

Ling Li, Ke Xie, Honghu Xie, Lei Wang, Zhong Li, Qicheng Lu, Jin Feng,

https://doi.org/10.18632/aging.205801 pp 8019—8030

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Sphingolipids in prostate cancer prognosis: integrating single-cell and bulk sequencing

Shan Zhou, Li Sun, Fei Mao, Jing Chen,

https://doi.org/10.18632/aging.205803 pp 8031—8043

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Bioinformatics analysis for constructing a cellular senescence-related age-related macular degeneration diagnostic model and identifying relevant disease subtypes to guide treatment

Shan Luo, Qiang Hu, Bo Jiang, Zhongyu Zhang, Dawei Sun,

https://doi.org/10.18632/aging.205804 pp 8044—8069

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KLF4 inhibited the senescence-associated secretory phenotype in ox-LDL-treated endothelial cells via PDGFRA/NAMPT/mitochondrial ROS

Haoran Ding, Jing Tong, Hao Lin, Fan Ping, Tongqing Yao, Zi Ye, Jiapeng Chu, Deqiang Yuan, Kangwei Wang, Xuebo Liu, Fei Chen,

https://doi.org/10.18632/aging.205805 pp 8070—8085

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Constructing a novel prognostic model for triple-negative breast cancer based on genes associated with vasculogenic mimicry

Yu Ren, Luyi Feng, Zhihua Tan, Fulin Zhou, Shu Liu,

https://doi.org/10.18632/aging.205806 pp 8086—8109

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Revealing prognostic insights of programmed cell death (PCD)-associated genes in advanced non-small cell lung cancer

Weiwei Dong, He Zhang, Li Han, Huixia Zhao, Yue Zhang, Siyao Liu, Jiali Zhang, Beifang Niu, Wenhua Xiao,

https://doi.org/10.18632/aging.205807 pp 8110—8141

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4-hydroxysesamin protects rat with right ventricular failure due to pulmonary hypertension by inhibiting JNK/p38 MAPK signaling

Lingnan Zhang, Xinshun Gu,

https://doi.org/10.18632/aging.205808 pp 8142—8154

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Bioinformatics analysis and validation of mesenchymal stem cells related gene MT1G in osteosarcoma

Sikuan Zheng, Xifu Cheng, Sulun Ke, Linyi Zhang, Hui Wu, Dingwen He, Xigao Cheng,

https://doi.org/10.18632/aging.205809 pp 8155—8170

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Pan-cancer analysis of LRRC59 with a focus on prognostic and immunological roles in hepatocellular carcinoma

Boyu Pan, Jun Cheng, Wei Tan, Xin Wu, Qizhi Fan, Lei Fan, Minghui Jiang, Rong Yu, Xiaoyun Cheng, Youwen Deng,

https://doi.org/10.18632/aging.205810 pp 8171—8197

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RNA sequencing-based approaches to identifying disulfidptosis-related diagnostic clusters and immune landscapes in osteoporosis

Peng Zhang, Bing Li, Honglin Chen, Zhilin Ge, Qi Shang, De Liang, Xiang Yu, Hui Ren, Xiaobing Jiang, Jianchao Cui,

https://doi.org/10.18632/aging.205813 pp 8198—8216

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Single-cell BCR and transcriptome analysis reveals peripheral immune signatures in patients with thyroid-associated ophthalmopathy

Qian Li, Ningyu An, Cheng Liu, Yungang Ding, Cuixia Yang, Xiumei Ma, Wei Yang, Junfeng Piao, Jinyan Zhu, Junxiu Liu,

https://doi.org/10.18632/aging.205814 pp 8217—8245

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Construction and validation of nomogram model for predicting the risk of ventricular arrhythmia after emergency PCI in patients with acute myocardial infarction

Wei Wang, Min Chen, Jiongchao Guo, Yuqi Wang, Jing Zhang,

https://doi.org/10.18632/aging.205815 pp 8246—8259

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HLA-B and TIMP1 as hub genes of the ventricular remodeling caused by hypertension

Gai-Feng Hu, Ling-Bing Meng, Jianyi Li, Jiapei Xu, Hong-Xuan Xu, De-Ping Liu,

https://doi.org/10.18632/aging.205816 pp 8260—8278

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Cancer-associated fibroblast-derived gene signature discriminates distinct prognoses by integrated single-cell and bulk RNA-seq analyses in breast cancer

Zhou Fang, Yi-Ling Han, Zhi-Jie Gao, Feng Yao,

https://doi.org/10.18632/aging.205817 pp 8279—8305

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Deciphering the causal relationship between plasma and cerebrospinal fluid metabolites and glioblastoma multiforme: a Mendelian Randomization study

Zhiwei Zhou, Haibin Leng,

https://doi.org/10.18632/aging.205818 pp 8306—8319

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Intracranial aneurysm circulating exosome-derived LncRNA ATP1A1-AS1 promotes smooth muscle cells phenotype switching and apoptosis

Chao Wang, Hong Li, Han Zhou, Yifan Xu, Shifang Li, Meng Zhu, Bing Yu, Yugong Feng,

https://doi.org/10.18632/aging.205821 pp 8320—8335

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Teneligliptin alleviates diabetes-related cognitive impairment by inhibiting the endoplasmic reticulum (ER) stress and NLRP3 inflammasome in mice

Weifeng Wang, Juanjuan Zhang,

https://doi.org/10.18632/aging.205333 pp 8336—8347

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ANGPTL4, a direct target of hsa-miR-133a-3p, accelerates lung adenocarcinoma lipid metabolism, proliferation and invasion

Qihao Hu, Shi Chen, Yukun Li, Teng Hu, Jianpeng Hu, Cheng Wang, Fei Yang, Xiang Yang, Feng Zhou, Zhengdong Liu, Wei Xu, Ji Zhang,

https://doi.org/10.18632/aging.205313 pp 8348—8360

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Comprehensive bioinformatics analytics and in vivo validation reveal SLC31A1 as an emerging diagnostic biomarker for acute myocardial infarction

Shujing Zhou, Longbin Wang, Xufeng Huang, Ting Wang, Yidan Tang, Ying Liu, Ming Xu,

https://doi.org/10.18632/aging.205199 pp 8361—8377

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Review

The beginning of becoming a human

Polina A. Loseva, Vadim N. Gladyshev,

https://doi.org/10.18632/aging.205824 pp 8378—8395

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Correction

Correction for: Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy

Buhui Liu, Yue Tu, Weiming He, Yinglu Liu, Wei Wu, Qijun Fang, Haitao Tang, Renmao Tang, Ziyue Wan, Wei Sun, Yigang Wan,

https://doi.org/10.18632/aging.205888 pp 8396—8398

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Retraction

Retraction for: Circular RNA ZNF609 drives tumor progression by regulating the miR-138-5p/SIRT7 axis in melanoma

Quan Liu, Wei Cui, Chao Yang, Li-Ping Du,

https://doi.org/10.18632/aging.205843 pp 8399

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