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Online ISSN: 1945-4589
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Special Collection on Cancer and mTOR


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Genetics of renal cancer: focus on MTOR

Arindam P. Ghosh, Sunil Sudarshan,
https://doi.org/10.18632/aging.100937 pp 421—422
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The PTEN tumor suppressor gene and its role in lymphoma pathogenesis

Xiaoxiao Wang, Huiqiang Huang, Ken H. Young,
https://doi.org/10.18632/aging.100855 pp 1032—1049
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Rapamycin in preventive (very low) doses

Roman V. Kondratov, Anna A. Kondratova,
https://doi.org/10.18632/aging.100645 pp 158—159
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Metformin and rapamycin are master-keys for understanding the relationship between cell senescent, aging and cancer

Vladimir N. Anisimov,
https://doi.org/10.18632/aging.100561 pp 337—338
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Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development

Yueyong Liu, Yurong Huang, Zeran Wang, Yong Huang, Xiaohua Li, Alexander Louie, Guangwei Wei, Jian-Hua Mao,
https://doi.org/10.18632/aging.100535 pp 111—119
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Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors

Carolina B. Livi, Rulon L. Hardman, Barbara A. Christy, Sherry G. Dodds, Diane Jones, Charnae Williams, Randy Strong, Alex Bokov, Martin A. Javors, Yuji Ikeno, Gene Hubbard, Paul Hasty, Zelton Dave Sharp,
https://doi.org/10.18632/aging.100533 pp 100—110
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Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling

H. Dorota Halicka, Hong Zhao, Jiangwei Li, Yong-Syu Lee, Tze-Chen Hsieh, Joseph M. Wu, Zbigniew Darzynkiewicz,
https://doi.org/10.18632/aging.100521 pp 952—965
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One-carbon metabolism: An aging-cancer crossroad for the gerosuppressant metformin

Javier A. Menendez, Jorge Joven,
https://doi.org/10.18632/aging.100523 pp 894—898
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New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis

Maria Comas, Ilia Toshkov, Karen K. Kuropatwinski, Olga B. Chernova, Alexander Polinsky, Mikhail V. Blagosklonny, Andrei V. Gudkov, Marina P. Antoch,
https://doi.org/10.18632/aging.100496 pp 715—722
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Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice

Elena A. Komarova, Marina P. Antoch, Liliya R. Novototskaya, Olga B. Chernova, Geraldine Paszkiewicz, Olga V. Leontieva, Mikhail V. Blagosklonny, Andrei V. Gudkov,
https://doi.org/10.18632/aging.100498 pp 709—714
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Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency

Lawrence A. Donehower,
https://doi.org/10.18632/aging.100494 pp 660—661
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Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.100475 pp 450—455
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Molecular damage in cancer: an argument for mTOR-driven aging

Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.100422 pp 1130—1141
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Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling

H. Dorota Halicka, Hong Zhao, Jiangwei Li, Frank Traganos, Sufang Zhang, Marietta Lee, Zbigniew Darzynkiewicz,
https://doi.org/10.18632/aging.100397 pp 1028—1038
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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

Linda S. Steelman, William H. Chappell, Stephen L. Abrams, C. Ruth Kempf, Jacquelyn Long, Piotr Laidler, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Franca Stivala, Maria C. Mazzarino, Marco Donia, Paolo Fagone, Graziella Malaponte, Ferdinando Nicoletti, Massimo Libra, Michele Milella, Agostino Tafuri, Antonio Bonati, Jörg Bäsecke, Lucio Cocco, Camilla Evangelisti, Alberto M. Martelli, Giuseppe Montalto, Melchiorre Cervello, James A. McCubrey,
https://doi.org/10.18632/aging.100296 pp 192—222
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Potential of mTOR inhibitors for the treatment of subependymal giant cell astrocytomas in tuberous sclerosis complex

Philippe Major,
https://doi.org/10.18632/aging.100298 pp 189—191
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Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells

Yiping Huang, Edward A. Ratovitski,
https://doi.org/10.18632/aging.100249 pp 959—968
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Age-related mTOR in gynaecological cancers

Preety Bajwa, Subhransu S. Sahoo, Pradeep S. Tanwar,
https://doi.org/10.18632/aging.101190 pp 301—302
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Gerosuppression by pan-mTOR inhibitors

Olga V. Leontieva, Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.101155 pp 3535—3551
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Towards specific inhibition of mTORC2

Elizabeth R. Murray, Angus J.M. Cameron,
https://doi.org/10.18632/aging.101346 pp 2461—2462
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Fasting for stem cell rejuvenation

Cristina González-Estévez, Ignacio Flores,
https://doi.org/10.18632/aging.102912 pp 4048—4049
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BMAL1 knockdown triggers different colon carcinoma cell fates by altering the delicate equilibrium between AKT/mTOR and P53/P21 pathways

Yuan Zhang, Aurore Devocelle, Lucas Souza, Adlen Foudi, Sabrina Tenreira Bento, Christophe Desterke, Rachel Sherrard, Annabelle Ballesta, Rene Adam, Julien Giron-Michel, Yunhua Chang,
https://doi.org/10.18632/aging.103124 pp 8067—8083
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BRD4 inhibition sensitizes renal cell carcinoma cells to the PI3K/mTOR dual inhibitor VS-5584

Ming Xu, Lijun Xu, Yin Wang, Guangcheng Dai, Boxin Xue, Yuan-yuan Liu, Jianbing Zhu, Jin Zhu,
https://doi.org/10.18632/aging.103723 pp 19147—19158
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SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling

Ming Xu, Xianglan Zhang, Songnan Zhang, Junjie Piao, Yang Yang, Xinyue Wang, Zhenhua Lin,
https://doi.org/10.18632/aging.202231 pp 1032—1050
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Deglycosylated EpCAM regulates proliferation by enhancing autophagy of breast cancer cells via PI3K/Akt/mTOR pathway

Liu Yang, Qijun Wang, Qian Zhao, Fan Yang, Tingjiao Liu, Xiaohua Huang, Qiu Yan, Xuesong Yang,
https://doi.org/10.18632/aging.203795 pp 316—329
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A comprehensive analysis of FOX family in HCC and experimental evidence to support the oncogenic role of FOXH1

Xiwu Ouyang, Lemeng Feng, Lei Yao, Jingyu Zhang, Yao Xiao, Guodong Liu, Gewen Zhang, Zhiming Wang,
https://doi.org/10.18632/aging.203934 pp 2268—2286
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Ox-LDL-mediated ILF3 overexpression in gastric cancer progression by activating the PI3K/AKT/mTOR signaling pathway

Danping Sun, Mingxiang Zhang, Meng Wei, Zhaoyang Wang, Wen Qiao, Peng Liu, Xin Zhong, Yize Liang, Yuanyuan Chen, Yadi Huang, Wenbin Yu,
https://doi.org/10.18632/aging.204051 pp 3887—3909
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Hallmarks of cancer and hallmarks of aging

Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.204082 pp 4176—4187
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