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• Research PaperVolume 12, Issue 11pp 10194-10210

  Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf/MEK/ERK and PI3K/Akt expression and chemotherapeutic drug sensitivity in prostate cancer cell lines

  Relevance score: 0.00

  William H. Chappell, Saverio Candido, Stephen L. Abrams, Shaw M. Akula, Linda S. Steelman, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Melchiorre Cervello, Giuseppe Montalto, Ferdinando Nicoletti, Massimo Libra, James A. McCubrey

  Keywords: TP53, DDR, rapamycin, RAF/MEK/ERK, collagen

  Published in Aging on June 3, 2020

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• Research PaperVolume 13, Issue 22pp 24640-24654

  PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway

  Relevance score: 0.00

  Haocong Zhang, Dulei Xiang, Xinwei Liu, Liangbi Xiang

  Keywords: PPARα agonist PEA, spinal cord injury, Nrf2/HO-1, Raf-1/MEK/ERK, TUNEL staining

  Published in Aging on November 19, 2021

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• ReviewVolume 3, Issue 3pp 192-222

  Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

  Relevance score: 0.00

  Linda S. Steelman, William H. Chappell, Stephen L. Abrams, C. Ruth Kempf, Jacquelyn Long, Piotr Laidler, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Franca Stivala, Maria C. Mazzarino, Marco Donia, Paolo Fagone, Graziella Malaponte, Ferdinando Nicoletti, Massimo Libra, Michele Milella, Agostino Tafuri, Antonio Bonati, Jörg Bäsecke, Lucio Cocco, Camilla Evangelisti, Alberto M. Martelli, Giuseppe Montalto, Melchiorre Cervello, James A. McCubrey

  Keywords: Raf, MEK, PI3K, mTOR, cancer, kinases, protein phosphorylation, signal transduction, apoptosis

  Published in Aging on March 10, 2011

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• Research PaperVolume 11, Issue 17pp 7187-7196

  STAT3 inhibitor sensitized KRAS-mutant lung cancers to RAF inhibitor by activating MEK/ERK signaling pathway

  Relevance score: 0.00

  Zhenlin Wang, Mengchen Yin, Peilin Chu, Meiqing Lou

  Keywords: RAF, STAT3, AZ628, BP-1-102, lung cancer harboring KRAS mutations

  Published in Aging on September 4, 2019

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