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• Research PaperVolume 9, Issue 11pp 2352-2375

  Targeted elimination of senescent Ras-transformed cells by suppression of MEK/ERK pathway

  Relevance score: 0.00

  Elena Y. Kochetkova, Galina I. Blinova, Olga A. Bystrova, Marina G. Martynova, Valery A. Pospelov, Tatiana V. Pospelova

  Keywords: senescence, autophagy, MEK/ERK, mitochondria, apoptosis

  Published in Aging on November 14, 2017

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• Research PaperVolume 13, Issue 3pp 3886-3897

  Praja2 suppresses the growth of gastric cancer by ubiquitylation of KSR1 and inhibiting MEK-ERK signal pathways

  Relevance score: 0.00

  Zhiwei Zhao, Lin Zhu, Yanwei Xing, Zhenan Zhang

  Keywords: gastric cancer, E3 ligase praja2, KSR1, MEK-ERK, tumorigenesis

  Published in Aging on January 10, 2021

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• Research PaperVolume 12, Issue 11pp 10194-10210

  Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf/MEK/ERK and PI3K/Akt expression and chemotherapeutic drug sensitivity in prostate cancer cell lines

  Relevance score: 0.00

  William H. Chappell, Saverio Candido, Stephen L. Abrams, Shaw M. Akula, Linda S. Steelman, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Melchiorre Cervello, Giuseppe Montalto, Ferdinando Nicoletti, Massimo Libra, James A. McCubrey

  Keywords: TP53, DDR, rapamycin, RAF/MEK/ERK, collagen

  Published in Aging on June 3, 2020

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• Research PaperVolume 10, Issue 11pp 3574-3589

  Suppression of mTORC1 activity in senescent Ras-transformed cells neither restores autophagy nor abrogates apoptotic death caused by inhibition of MEK/ERK kinases

  Relevance score: 0.00

  Elena Y. Kochetkova, Galina I. Blinova, Olga A. Bystrova, Marina G. Martynova, Valeriy A. Pospelov, Tatiana V. Pospelova

  Keywords: senescence, mitochondria damage, lysosomes, autophagy, mTOR, MEK/ERK, kinase inhibitors

  Published in Aging on November 27, 2018

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• Research PaperVolume 13, Issue 22pp 24640-24654

  PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway

  Relevance score: 0.00

  Haocong Zhang, Dulei Xiang, Xinwei Liu, Liangbi Xiang

  Keywords: PPARα agonist PEA, spinal cord injury, Nrf2/HO-1, Raf-1/MEK/ERK, TUNEL staining

  Published in Aging on November 19, 2021

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• ReviewVolume 3, Issue 3pp 192-222

  Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

  Relevance score: 0.00

  Linda S. Steelman, William H. Chappell, Stephen L. Abrams, C. Ruth Kempf, Jacquelyn Long, Piotr Laidler, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Franca Stivala, Maria C. Mazzarino, Marco Donia, Paolo Fagone, Graziella Malaponte, Ferdinando Nicoletti, Massimo Libra, Michele Milella, Agostino Tafuri, Antonio Bonati, Jörg Bäsecke, Lucio Cocco, Camilla Evangelisti, Alberto M. Martelli, Giuseppe Montalto, Melchiorre Cervello, James A. McCubrey

  Keywords: Raf, MEK, PI3K, mTOR, cancer, kinases, protein phosphorylation, signal transduction, apoptosis

  Published in Aging on March 10, 2011

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• Research PaperVolume 14, Issue 8pp 3597-3606

  Synergistic blocking of RAS downstream signaling and epigenetic pathway in KRAS mutant pancreatic cancer

  Relevance score: 0.00

  Xiaofei Zhang, Tiebo Mao, Haiyan Xu, Shumin Li, Ming Yue, Jingyu Ma, Jiayu Yao, Yongchao Wang, Xiao Zhang, Weiyu Ge, Yanling Wang, Daiyuan Shentu, Liwei Wang

  Keywords: pancreatic ductal adenocarcinoma, MEK inhibitor, BET inhibitor, synergistic effect, autophagy

  Published in Aging on April 25, 2022

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