Volume 9, Issue 1

January 2017
pp 1—296

About the Cover

The cover for issue 1 of Aging features Figure 3B, ''The complex genetics of gait speed: genome-wide meta-analysis approach" from Ben-Avraham et al.

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Editorials

Cell recruitment in gastric carcinogenesis

Songhua Zhang, Steven F. Moss,

https://doi.org/10.18632/aging.101164 pp 1—2

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ESR1 mutations in breast cancer

Florian Clatot, Laetitia Augusto, Frédéric Di Fiore,

https://doi.org/10.18632/aging.101165 pp 3—4

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Targeting BRAF-mutant tumours with TGFBR1 inhibitors

Lindsay C. Spender, Gareth J. Inman,

https://doi.org/10.18632/aging.101169 pp 5—6

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Meeting Report

A review of the biomedical innovations for healthy longevity

Alexey Moskalev, Vladimir Anisimov, Aleksander Aliper, Artem Artemov, Khusru Asadullah, Daniel Belsky, Ancha Baranova, Aubrey de Grey, Vishwa Deep Dixit, Edouard Debonneuil, Eugenia Dobrovolskaya, Peter Fedichev, Alexander Fedintsev, Vadim Fraifeld, Claudio Franceschi, Rosie Freer, Tamas Fülöp, Jerome Feige, David Gems, Vadim Gladyshev, Vera Gorbunova, Irina Irincheeva, Sibylle Jager, S. Michal Jazwinski, Matt Kaeberlein, Brian Kennedy, Daria Khaltourina, Igor Kovalchuk, Olga Kovalchuk, Sergey Kozin, Alexander Kulminski, Ekaterina Lashmanova, Ksenia Lezhnina, Guang-Hui Liu, Valter Longo, Polina Mamoshina, Alexander Maslov, Joao Pedro de Magalhaes, James Mitchell, Arnold Mitnitski, Yuri Nikolsky, Ivan Ozerov, Elena Pasyukova, Darya Peregudova, Vasily Popov, Ekaterina Proshkina, Evgeny Putin, Evgeny Rogaev, Blanka Rogina, Jane Schastnaya, Andrey Seluanov, Mikhail Shaposhnikov, Andreas Simm, Vladimir Skulachev, Maxim Skulachev, Ilya Solovev, Stephen Spindler, Natalia Stefanova, Yousin Suh, Andrew Swick, John Tower, Andrei V. Gudkov, Jan Vijg, Andrey Voronkov, Michael West, Wolfgang Wagner, Anatoliy Yashin, Nadezhda Zemskaya, Zhaxybay Zhumadilov, Alex Zhavoronkov,

https://doi.org/10.18632/aging.101163 pp 7—25

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Research Papers

Transcriptional regulation of PNPLA3 and its impact on susceptibility to nonalcoholic fatty liver Disease (NAFLD) in humans

Wanqing Liu, Quentin M Anstee, Xiaoliang Wang, Samer Gawrieh, Eric R. Gamazon, Shaminie Athinarayanan, Yang-Lin Liu, Rebecca Darlay, Heather J Cordell, Ann K Daly, Chris P Day, Naga Chalasani,

https://doi.org/10.18632/aging.101067 pp 26—40

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Novel cellular evidence of lipophagy within the Sertoli cells during spermatogenesis in the turtle

Nisar Ahmed, Yi Liu, Hong Chen, Ping Yang, Yasir Waqas, Tengfei Liu, Jameel Ahmed Gandahi, Yufei Huang, Lingling Wang, Xuejing Song, Imran Rashid Rajput, Taozhi Wang, Qiusheng Chen,

https://doi.org/10.18632/aging.101070 pp 41—51

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Evidence of a metabolic reserve in the skeletal muscle of elderly people

Gwenael Layec, Joel D. Trinity, Corey R. Hart, Yann Le Fur, Jacob R. Sorensen, Eun-Kee Jeong, Russell S. Richardson,

https://doi.org/10.18632/aging.101079 pp 52—67

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Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae

Gregory Tombline, Jonathan I. Millen, Bogdan Polevoda, Matan Rapaport, Bonnie Baxter, Michael Van Meter, Matthew Gilbertson, Joe Madrey, Gary A. Piazza, Lynn Rasmussen, Krister Wennerberg, E. Lucile White, John L. Nitiss, David S. Goldfarb,

https://doi.org/10.18632/aging.101114 pp 68—97

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Aging enhances liver fibrotic response in mice through hampering extracellular matrix remodeling

Bénédicte Delire, Valérie Lebrun, Charlotte Selvais, Patrick Henriet, Amélie Bertrand, Yves Horsmans, Isabelle A. Leclercq,

https://doi.org/10.18632/aging.101124 pp 98—113

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Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis

Massimiliano Mellone, Christopher J. Hanley, Steve Thirdborough, Toby Mellows, Edwin Garcia, Jeongmin Woo, Joanne Tod, Steve Frampton, Veronika Jenei, Karwan A. Moutasim, Tasnuva D. Kabir, Peter A Brennan, Giulia Venturi, Kirsty Ford, Nicolas Herranz, Kue Peng Lim, James Clarke, Daniel W. Lambert, Stephen S. Prime, Timothy J. Underwood, Pandurangan Vijayanand, Kevin W. Eliceiri, Christopher Woelk, Emma V. King, Jesus Gil, Christian H. Ottensmeier, Gareth J. Thomas,

https://doi.org/10.18632/aging.101127 pp 114—132

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Association of neovascular age-related macular degeneration with month and season of birth in Italy

Antonio Longo, Alessandra Casuccio, Luca Pani, Teresio Avitabile, Salvatore Cillino, Maurizio G. Uva, Vincenza Bonfiglio, Andrea Russo, Guglielmo Parisi, Gilda Cennamo, Claudio Furino, Mariacristina Parravano, Entela Xoxi, Michele Reibaldi,

https://doi.org/10.18632/aging.101137 pp 133—141

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Hypothalamic S1P/S1PR1 axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise

Vagner Ramon Rodrigues Silva, Carlos Kiyoshi Katashima, Carla G. Bueno Silva, Luciene Lenhare, Thayana Oliveira Micheletti, Rafael Ludemann Camargo, Ana Carolina Ghezzi, Juliana Alves Camargo, Alexandre Moura Assis, Natalia Tobar, Joseane Morari, Daniela S. Razolli, Leandro Pereira Moura, José Rodrigo Pauli, Dennys Esper Cintra, Lício Augusto Velloso, Mario J.A Saad, Eduardo Rochete Ropelle,

https://doi.org/10.18632/aging.101138 pp 142—155

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Salvia miltiorrhiza bunge increases estrogen level without side effects on reproductive tissues in immature/ovariectomized mice

Ying Xu, Ting Chen, Xin Li, Ya-kun Qu, Jin-na An, Hong-xia Zheng, Zi-jia Zhang, Na Lin,

https://doi.org/10.18632/aging.101145 pp 156—172

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Impaired fasting blood glucose is associated to cognitive impairment and cerebral atrophy in middle-aged non-human primates

Fathia Djelti, Marc Dhenain, Jérémy Terrien, Jean-Luc Picq, Isabelle Hardy, Delphine Champeval, Martine Perret, Esther Schenker, Jacques Epelbaum, Fabienne Aujard,

https://doi.org/10.18632/aging.101148 pp 173—186

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Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress

Jessica R. Santos-Parker, Talia R. Strahler, Candace J. Bassett, Nina Z. Bispham, Michel B. Chonchol, Douglas R. Seals,

https://doi.org/10.18632/aging.101149 pp 187—208

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The complex genetics of gait speed: genome-wide meta-analysis approach

Dan Ben-Avraham, David Karasik, Joe Verghese, Kathryn L. Lunetta, Jennifer A. Smith, John D. Eicher, Rotem Vered, Joris Deelen, Alice M. Arnold, Aron S. Buchman, Toshiko Tanaka, Jessica D. Faul, Maria Nethander, Myriam Fornage, Hieab H. Adams, Amy M. Matteini, Michele L. Callisaya, Albert V. Smith, Lei Yu, Philip L. De Jager, Denis A. Evans, Vilmundur Gudnason, Albert Hofman, Alison Pattie, Janie Corley, Lenore J. Launer, Davis S. Knopman, Neeta Parimi, Stephen T. Turner, Stefania Bandinelli, Marian Beekman, Danielle Gutman, Lital Sharvit, Simon P. Mooijaart, David C. Liewald, Jeanine J. Houwing-Duistermaat, Claes Ohlsson, Matthijs Moed, Vincent J. Verlinden, Dan Mellström, Jos N. van der Geest, Magnus Karlsson, Dena Hernandez, Rebekah McWhirter, Yongmei Liu, Russell Thomson, Gregory J. Tranah, Andre G. Uitterlinden, David R. Weir, Wei Zhao, John M. Starr, Andrew D. Johnson, M. Arfan Ikram, David A. Bennett, Steven R. Cummings, Ian J. Deary, Tamara B. Harris, Sharon L. R. Kardia, Thomas H. Mosley, Velandai K. Srikanth, Beverly G. Windham, Ann B. Newman, Jeremy D. Walston, Gail Davies, Daniel S. Evans, Eline P. Slagboom, Luigi Ferrucci, Douglas P. Kiel, Joanne M. Murabito, Gil Atzmon,

https://doi.org/10.18632/aging.101151 pp 209—246

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Investigation of the 5q33.3 longevity locus and age-related phenotypes

Marianne Nygaard, Mikael Thinggaard, Kaare Christensen, Lene Christiansen,

https://doi.org/10.18632/aging.101156 pp 247—255

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Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal osteopenic women following a one-year double-blind RCT and on osteoblast-osteoclast co-cultures

Sifat Maria, Mark H. Swanson, Larry T. Enderby, Frank D’Amico, Brianna Enderby, Rebekah M. Samsonraj, Amel Dudakovic, Andre J. van Wijnen, Paula A. Witt-Enderby,

https://doi.org/10.18632/aging.101158 pp 256—285

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AKI-CLIF-SOFA: a novel prognostic score for critically ill cirrhotic patients with acute kidney injury

Dan-Qin Sun, Chen-Fei Zheng, Wen-Yue Liu, Sven Van Poucke, Zhi Mao, Ke-Qing Shi, Xiao-Dong Wang, Ji-Dong Wang, Ming-Hua Zheng,

https://doi.org/10.18632/aging.101161 pp 286—296

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