Volume 16, Issue 7

April 15, 2024pp 5796—6630

About the Cover

The cover features Figure 1 "Stemness levels during human aging" from Dos Santos et al.

Research Papers

Evidence of a pan-tissue decline in stemness during human aging

Gabriel Arantes dos Santos, Gustavo Daniel Vega Magdaleno, João Pedro de Magalhães

https://doi.org/10.18632/aging.205717pp 5796—5810

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The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats

Jennifer M. Rutkowsky, Zabrisky Roland, Anthony Valenzuela, An B. Nguyen, Heui Hye Park, Natalie Six, Ilknur Dursun, Kyoungmi Kim, Pamela J. Lein, Jon J. Ramsey

https://doi.org/10.18632/aging.205741pp 5811—5828

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The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background

Stephen A. Banse, E. Grace Jackson, Christine A. Sedore, Brian Onken, David Hall, Anna Coleman-Hulbert, Phu Huynh, Theo Garrett, Erik Johnson, Girish Harinath, Delaney Inman, Suzhen Guo, Mackenzie Morshead, Jian Xue, Ron Falkowski, Esteban Chen, Christopher Herrera, Allie J. Kirsch, Viviana I. Perez, Max Guo, Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips

https://doi.org/10.18632/aging.205743pp 5829—5855

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miR-30d-5p inhibits proliferation, invasion and migration of breast cancer cells by targeting SERPINE1 and promoting fatty acid β-oxidation

Lina Zhang, Shuguang Ren, Yang Sang, Yueyang Hu, Cong Wang, Xinrui Wang, Yuntao Li

https://doi.org/10.18632/aging.205587pp 5856—5865

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NXPH4 can be used as a biomarker for pan-cancer and promotes colon cancer progression

Zhipeng Zhang, Pengfei Wang, Siwen Chen, Dezhi Xiang, Jinzhen Chen, Wanchang Huang, Xiao Liu, Tongwen Yi, Dawei Wang, Yunfei Pu, Longfu He, Hao Zhang

https://doi.org/10.18632/aging.205648pp 5866—5886

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Cordyceps sinensis extract protects against acute kidney injury by inhibiting perforin expression in NK cells via the STING/IRF3 pathway

Shuang Li, Wei Pang, Yuzhu Wang, Yiting Zhang

https://doi.org/10.18632/aging.205676pp 5887—5904

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Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway

Yunfang Yang, Changjiang Li, Sijin Yang, Zhuo Zhang, Xue Bai, Hongmei Tang, Jiang Huang

https://doi.org/10.18632/aging.205678pp 5905—5915

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Downregulating miRNA-199a-5p exacerbates fluorouracil-induced cardiotoxicity by activating the ATF6 signaling pathway

Wei Wang, Liang Dong, Hengxu Lv, Yonghui An, Changwang Zhang, Zheng Zheng, Ying Guo, Li He, Libin Wang, Jinmei Wang, Xinlei Shi, Na Li, Mingqi Zheng

https://doi.org/10.18632/aging.205679pp 5916—5928

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RNA splicing regulator EIF3D regulates the tumor microenvironment through immunogene-related alternative splicing in head and neck squamous cell carcinoma

Dandan Lu, Mijti Mihoayi, Yimin Ablikim, Abdeyrim Arikin

https://doi.org/10.18632/aging.205681pp 5929—5948

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Identification of key pathways and mRNAs in interstitial cystitis/bladder pain syndrome treatment with quercetin through bioinformatics analysis of mRNA-sequence data

Guang Wang, Pei Li, Si-Wei Su, Rui Xu, Zi-Ye Huang, Tong-Xin Yang, Jiong-Ming Li

https://doi.org/10.18632/aging.205682pp 5949—5966

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Identification and validation of DHCR7 as a diagnostic biomarker involved in the proliferation and mitochondrial function of breast cancer

Yanfeng Wang, Jiaxin Fan, Yongcheng Liu, Jie Du, Boyu Liang, Huxia Wang, Zhangjun Song

https://doi.org/10.18632/aging.205683pp 5967—5986

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Identification and validation of the biomarkers related to ferroptosis in calcium oxalate nephrolithiasis

Chao Hou, Bing Zhong, Shuo Gu, Yunyan Wang, Lu Ji

https://doi.org/10.18632/aging.205684pp 5987—6007

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Novel insights into the pathogenesis of thyroid eye disease through ferroptosis-related gene signature and immune infiltration analysis

Yunyan Ye, Lei Dai, Joseph Mugaanyi, Weina Fu, Feng Hu

https://doi.org/10.18632/aging.205685pp 6008—6034

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Exploration of signature based on T cell-related genes in stomach adenocarcinoma by analysis of single cell sequencing data

Huimei Wang, Nan An, Aiyue Pei, Yongxiao Sun, Shuo Li, Si Chen, Nan Zhang

https://doi.org/10.18632/aging.205687pp 6035—6053

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Identification of a novel disulfideptosis-related gene signature for prognostic implication in lower-grade gliomas

Fuqiang Zhang, Meihong Lv, Yi He

https://doi.org/10.18632/aging.205688pp 6054—6067

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Associations of PD-1 and PD-L1 gene polymorphisms with cancer risk: a meta-analysis based on 50 studies

Maoquan Yang, Yan Liu, Shuangshuang Zheng, Peizhen Geng, Tianhao He, Linan Lu, Yikuan Feng, Qiqi Jiang

https://doi.org/10.18632/aging.205689pp 6068—6097

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The necroptosis-related signature and tumor microenvironment immune characteristics associated with clinical prognosis and drug sensitivity analysis in stomach adenocarcinoma

Biao Yang, Yingnan Wang, Tao Liu, Meijing Zhang, Tianhang Luo

https://doi.org/10.18632/aging.205690pp 6098—6117

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A novel risk signature based on liquid-liquid phase separation-related genes reveals prognostic and tumour microenvironmental features in clear cell renal cell carcinoma

Qing Lu, Ping Xi, Suling Xu, Zhicheng Zhang, Binbin Gong, Ji Liu, Qiqi Zhu, Ting Sun, Shaoxing Zhu, Ru Chen

https://doi.org/10.18632/aging.205691pp 6118—6134

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Lifibrate attenuates blood-brain barrier damage following ischemic stroke via the MLCK/p-MLC/ZO-1 axis

Yu Duan, Yao Deng, Feng Tang, Jian Li

https://doi.org/10.18632/aging.205692pp 6135—6146

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Poria cocos polysaccharides improve alcoholic liver disease by interfering with ferroptosis through NRF2 regulation

Xiangyu Zhou, Jincheng Wang, Sufang Zhou

https://doi.org/10.18632/aging.205693pp 6147—6162

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KIF3C: an emerging biomarker with prognostic and immune implications across pan-cancer types and its experiment validation in gastric cancer

Qiangqiang Zhong, Wenbo Hong, Lina Xiong

https://doi.org/10.18632/aging.205694pp 6163—6187

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Potential value of expression of receptor accessory protein 4 for evaluating the prognosis of lower-grade glioma patients

Shuping Luo, Zhendong Liu, Haigang Chang, Xingbo Cheng, Rongjun Qian, Yanzheng Gao, Chaofeng Hou

https://doi.org/10.18632/aging.205695pp 6188—6211

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A retrospective study on the effect of Chinese patent medicine combined with conventional treatment on the survival outcomes of 313 patients with stage II–III NSCLC

Kegang Jia, Chenxu Zhang, Fang Li, Bin He, Shenglong Xie, Jun Du, Gang Feng

https://doi.org/10.18632/aging.205697pp 6212—6228

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Role of CCR1/5/7 in hepatocellular carcinoma: a study on prognostic evaluation, molecular subtyping, and association with immune infiltration

Huasheng Huang, Chenlu Lan, Yongguang Wei, Jusen Nong, Xiwen Liao, Xinping Ye, Ganlu Deng, Tao Peng, Xin Zhou

https://doi.org/10.18632/aging.205698pp 6229—6261

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Identification and characterization of circular RNAs expression profiles in obstructive sleep apnea-induced liver injury

Chaowei Li, Jinhuang Lin, Qingshi Chen, Yueyong Zhu

https://doi.org/10.18632/aging.205701pp 6262—6272

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Human umbilical cord-derived mesenchymal stem cells and auto-crosslinked hyaluronic acid gel complex for treatment of intrauterine adhesion

Jiaying Fan, Jingying Xie, Yunsheng Liao, Baoyu Lai, Guixin Zhou, Wenqin Lian, Jian Xiong

https://doi.org/10.18632/aging.205704pp 6273—6289

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Identifying an immunogenic cell death-related gene signature contributes to predicting prognosis, immunotherapy efficacy, and tumor microenvironment of lung adenocarcinoma

Xue Li, Dengfeng Zhang, Pengfei Guo, Shaowei Ma, Shaolin Gao, Shujun Li, Yadong Yuan

https://doi.org/10.18632/aging.205705pp 6290—6313

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Machine learning identifies novel coagulation genes as diagnostic and immunological biomarkers in ischemic stroke

Jinzhi Liu, Zhihua Si, Ju Liu, Xu Zhang, Cong Xie, Wei Zhao, Aihua Wang, Zhangyong Xia

https://doi.org/10.18632/aging.205706pp 6314—6333

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Lactobacillus plantarum 45 activates SHP2 through inhibition of oxidative stress to regulate osteoblast and osteoclast differentiation

Yaming Yang, Zheng Yan, Qi Xie, Yong Wang, Zhiying Liu, Min Lei

https://doi.org/10.18632/aging.205708pp 6334—6347

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Inflammatory risk of albumin combined with C-reactive protein predicts long-term cardiovascular risk in patients with diabetes

Xiaoqun Xu, Houyong Zhu, Hanxin Wang, Xinyu Zhu, Libin Liu, Fengwei Zhang, Hongjuan Zhou, Mingzhi Zhu, Lingshan Dai, Long Cai

https://doi.org/10.18632/aging.205709pp 6348—6363

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Metabolic score for insulin resistance predicts major adverse cardiovascular event in premature coronary artery disease

Dachuan Guo, Chong Zhang, Mingyan Zhang, Zhenguo Wu, Xiaoyu Liu, Yerui Zhang, Li Liu, Meili Sun, Jianmin Yang

https://doi.org/10.18632/aging.205710pp 6364—6383

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Using genetics and proteomics data to identify proteins causally related to COVID-19, healthspan and lifespan: a Mendelian randomization study

Jie V. Zhao, Minhao Yao, Zhonghua Liu

https://doi.org/10.18632/aging.205711pp 6384—6416

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Pan-cancer analysis of Sushi domain-containing protein 4 (SUSD4) and validated in colorectal cancer

Yuchen Zhong, Chaojing Zheng, Weiyuan Zhang, Hongyu Wu, Qian Zhang, Dechuan Li, Haixing Ju, Haiyang Feng, Yinbo Chen, Yongtian Fan, Weiping Chen, Meng Wang, Guiyu Wang

https://doi.org/10.18632/aging.205712pp 6417—6444

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Risk assessment of extra-uterine involvement and prognosis in young type I endometrial carcinoma with high or moderate differentiation and less than 1/2 myometrial invasion

Yi Sun, Pin Han, Yuanpei Wang, Xiaoran Cheng, Weijia Wu, Qianwen Liu, Fang Ren

https://doi.org/10.18632/aging.205714pp 6445—6454

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Machine learning for identifying tumor stemness genes and developing prognostic model in gastric cancer

Guo-Xing Li, Yun-Peng Chen, You-Yang Hu, Wen-Jing Zhao, Yun-Yan Lu, Fu-Jian Wan, Zhi-Jun Wu, Xiang-Qian Wang, Qi-Ying Yu

https://doi.org/10.18632/aging.205715pp 6455—6477

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Stigmasterol alleviates airway inflammation in OVA-induced asthmatic mice via inhibiting the TGF-β1/Smad2 and IL-17A signaling pathways

Sihong Huang, Rong Zhou, Yuyun Yuan, Yiyun Shen

https://doi.org/10.18632/aging.205716pp 6478—6487

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Multidimensional data analysis revealed thyroiditis-associated TCF19 SNP rs2073724 as a highly ranked protective variant in thyroid cancer

Xianhui Ruan, Yu Liu, Shuping Wu, Guiming Fu, Mei Tao, Yue Huang, Dapeng Li, Songfeng Wei, Ming Gao, Shicheng Guo, Junya Ning, Xiangqian Zheng

https://doi.org/10.18632/aging.205718pp 6488—6509

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has-miR-134-5p inhibits the proliferation and migration of glioma cells by regulating the BDNF/ERK signaling pathway

Zeshang Guo, Pingxv An, Xinyu Hong

https://doi.org/10.18632/aging.205720pp 6510—6520

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Garlic oil supplementation blocks inflammatory pyroptosis-related acute lung injury by suppressing the NF-κB/NLRP3 signaling pathway via H₂S generation

Tursunay Dilxat, Qiang Shi, Xiaofan Chen, Xuxin Liu

https://doi.org/10.18632/aging.205721pp 6521—6536

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A prognostic signature established based on genes related to tumor microenvironment for patients with hepatocellular carcinoma

Zhongfeng Cui, Ge Li, Yanbin Shi, Xiaoli Zhao, Juan Wang, Shanlei Hu, Chunguang Chen, Guangming Li

https://doi.org/10.18632/aging.205722pp 6537—6549

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Single-cell data revealed exhaustion of characteristic NK cell subpopulations and T cell subpopulations in hepatocellular carcinoma

Zhongfeng Cui, Hongzhi Li, Chunli Liu, Juan Wang, Chunguang Chen, Shanlei Hu, Xiaoli Zhao, Guangming Li

https://doi.org/10.18632/aging.205723pp 6550—6565

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Transcranial direct current stimulation promotes angiogenesis and improves neurological function via the OXA-TF-AKT/ERK signaling pathway in traumatic brain injury

Bingkai Ren, Junwei Kang, Yan Wang, Xiangqiang Meng, Ying Huang, Yang Bai, Zhen Feng

https://doi.org/10.18632/aging.205724pp 6566—6587

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TGF-β downstream of Smad3 and MAPK signaling antagonistically regulate the viability and partial epithelial–mesenchymal transition of liver progenitor cells

Yi-Min Sun, Yu Wu, Gan-Xun Li, Hui-Fang Liang, Tu-Ying Yong, Zifu Li, Bixiang Zhang, Xiao-Ping Chen, Guan-Nan Jin, Ze-Yang Ding

https://doi.org/10.18632/aging.205725pp 6588—6612

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Review

The mechanism of USP43 in the development of tumor: a literature review

Ziqi Zhao, Meichen Liu, Zhikun Lin, Mengru Zhu, Linlin Lv, Xinqing Zhu, Rui Fan, Abdullah Al-Danakh, Hui He, Guang Tan

https://doi.org/10.18632/aging.205731pp 6613—6626

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Corrections

Correction for: Inhibition of circulating exosomal microRNA-15a-3p accelerates diabetic wound repair

Yuan Xiong, Lang Chen, Tao Yu, Chenchen Yan, Wu Zhou, Faqi Cao, Xiaomeng You, Yingqi Zhang, Yun Sun, Jing Liu, Hang Xue, Yiqiang Hu, Dong Chen, Bobin Mi, Guohui Liu

https://doi.org/10.18632/aging.205514pp 6627—6628

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Correction for: MTDH promotes metastasis of clear cell renal cell carcinoma by activating SND1-mediated ERK signaling and epithelial-mesenchymal transition

Anbang He, Shiming He, Cong Huang, Zhicong Chen, Yucai Wu, Yanqing Gong, Xuesong Li, Liqun Zhou

https://doi.org/10.18632/aging.205603pp 6629—6630

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