Volume 15, Issue 17

September 15, 2023pp 8531—9232

About the Cover

The cover features Figure 1 "Basic principles of the 1st and next gen DNAme EN clocks" from Mei et al.

Editorials

Promising trends in lung cancer care, but are we overlooking the majority?

Bhavina Sharma, Apar Kishor Ganti

https://doi.org/10.18632/aging.204662pp 8531—8532

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The tale of young blood rejuvenating the old

Xiaogang Chu, Raghavan Pillai Raju

https://doi.org/10.18632/aging.205069pp 8533—8534

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R-loops in neuronal aging

Hana Hall

https://doi.org/10.18632/aging.205070pp 8535—8536

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Research Perspective

A Poisson distribution-based general model of cancer rates and a cancer risk-dependent theory of aging

Wenbo Yu, Tessa Gargett, Zhenglong Du

https://doi.org/10.18632/aging.205016pp 8537—8551

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Priority Research Paper

Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease

Xiaoyue Mei, Joshua Blanchard, Connor Luellen, Michael J. Conboy, Irina M. Conboy

https://doi.org/10.18632/aging.205046pp 8552—8575

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Research Papers

Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes

Mélina Georget, Anaïs Defois, Romain Guiho, Nina Bon, Sophie Allain, Cécile Boyer, Boris Halgand, Denis Waast, Gaël Grimandi, Alban Fouasson-Chailloux, Jérôme Guicheux, Claire Vinatier

https://doi.org/10.18632/aging.204881pp 8576—8593

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Availability of living donor optimizes timing of liver transplant in high-risk waitlisted cirrhosis patients

Fakhar Ali Qazi Arisar, Shiyi Chen, Catherine Chen, Noorulsaba Shaikh, Ravikiran Sindhuvalada Karnam, Wei Xu, Sumeet K. Asrani, Zita Galvin, Gideon Hirschfield, Keyur Patel, Cynthia Tsien, Nazia Selzner, Mark Cattral, Leslie Lilly, Mamatha Bhat

https://doi.org/10.18632/aging.204982pp 8594—8612

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NRP1 regulates autophagy and proliferation of gastric cancer through Wnt/β-catenin signaling pathway

Qi-Ying Yu, Yue Han, Jia-Hui Lu, Yan-Jie Sun, Xing-Hua Liao

https://doi.org/10.18632/aging.204560pp 8613—8629

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Prognostic model of kidney renal clear cell carcinoma using aging-related long noncoding RNA signatures identifies THBS1-IT1 as a potential prognostic biomarker for multiple cancers

Yi-Fan Tang, Yu-Zhi Wang, Gui-Biao Wen, Jian-Jun Jiang

https://doi.org/10.18632/aging.204949pp 8630—8663

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Pan-cancer analysis and experimental validation revealed the m6A methyltransferase KIAA1429 as a potential biomarker for diagnosis, prognosis, and immunotherapy

Chao Ma, Qiming Zheng, Yepeng Wang, Guoxiang Li, Mengmeng Zhao, Zhigang Sun

https://doi.org/10.18632/aging.204968pp 8664—8691

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IFNγ synergies with cold atmospheric plasma in triggering colorectal cancer cell ferroptosis via the IFNγ/IFNR2/APC/TCF4/GPX4 axis

Xinyu Lv, Fu-le He, Yilin Dai, Xiaofeng Dai

https://doi.org/10.18632/aging.204985pp 8692—8711

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HNRNPA2B1 is a potential biomarker of breast cancer related to prognosis and immune infiltration

Aisikeer Ayoufu, Lina Yi, Muhairemu Tuersuntuoheti, Yongtao Li

https://doi.org/10.18632/aging.204992pp 8712—8728

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Uncovering the pathogenesis of obesity complicated with papillary thyroid carcinoma via bioinformatics and experimental validation

Kaisheng Yuan, Di Hu, Xiaocong Mo, Ruiqi Zeng, Bing Wu, Zunhao Zhang, Ruixiang Hu, Cunchuan Wang

https://doi.org/10.18632/aging.204993pp 8729—8743

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Comprehensive analysis and experimental validation reveal elevated CLCN4 is a promising biomarker in endometrial cancer

Chenyang Wang, Jing Li, Weina Liu, Shiya Li, Yi Zhang, Yanbin Jin, Jinquan Cui

https://doi.org/10.18632/aging.204994pp 8744—8769

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Prognostic value of lactate dehydrogenase in patients with uveal melanoma treated with immune checkpoint inhibition

Xiaocui Liang, Shan Zhou, Zefeng Xiao

https://doi.org/10.18632/aging.204996pp 8770—8781

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Integrative analyses reveal biological function and prognostic role of m7G methylation regulators in high-grade glioma

Xiaoli Li, Yanyan Li, Na Li, Liangfang Shen, Zhanzhan Li

https://doi.org/10.18632/aging.204999pp 8782—8799

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Bioinformatics approach and experimental validation reveal the hepatoprotective effect of pachyman against acetaminophen-associated liver injury

Ka Wu, Jingru Qin, Meizhen Liu, Xin Yan, Chao Guo

https://doi.org/10.18632/aging.205000pp 8800—8811

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SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells

Yan Wang, Jing-Miao Wang, Yuan Xiao, Xue-Bin Hu, Shu-Yu Zheng, Jia-Ling Fu, Lan Zhang, Yu-Wen Gan, Xing-Miao Liang, David Wan-Cheng Li

https://doi.org/10.18632/aging.205001pp 8812—8832

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Yuli Wang, Tao Yue, Qingqing He

https://doi.org/10.18632/aging.205002pp 8833—8850

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Integrative analysis identifies AKAP8L as an immunological and prognostic biomarker of pan-cancer

Libo Zhou, Jinhong Mei, Runfu Cao, Xiaoqiang Liu, Bin Fu, Ming Ma, Binbin Gong, Lianmin Luo, Yifu Liu, Qiqi Zhu, Xuan Meng

https://doi.org/10.18632/aging.205003pp 8851—8872

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Identification of ROCK1 as a novel biomarker for postmenopausal osteoporosis and pan-cancer analysis

Bowen Lai, Heng Jiang, Yuan Gao, Xuhui Zhou

https://doi.org/10.18632/aging.205004pp 8873—8907

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TIMP1 shapes an immunosuppressive microenvironment by regulating anoikis to promote the progression of clear cell renal cell carcinoma

Qiang Li, Kai Wei, Xi Zhang, Yang Lv, Miao Li, Chenchao Zhou, Shifeng Su, Daorong Hou, Jianquan Hou

https://doi.org/10.18632/aging.205005pp 8908—8929

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A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma

Tianyu Wang, Kang Xia, Tao Qiu, Shangting Han, Zhongbao Chen, Xiaoxiong Ma, Long Zhang, Jilin Zou, Yalong Zhang, Bo Yu, Chenyang Kong, Jiayu Guo, Yiting Liu, Jiangqiao Zhou, Shusen Zheng

https://doi.org/10.18632/aging.205008pp 8930—8947

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Prognostic value and immunological role of CSNK1D in human cancers

Jianguo Wang, Baohong Hu, Weixing Wang

https://doi.org/10.18632/aging.205009pp 8948—8975

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Herpesvirus latent infection promotes stroke via activating the OTUD1/NF-κB signaling pathway

Jiacai Lin, Yangrui Zheng, Ning Zhao, Fang Cui, Siting Wu

https://doi.org/10.18632/aging.205011pp 8976—8992

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Identification and validation of a prognostic signature of cuproptosis-related genes for esophageal squamous cell carcinoma

Yiping Zhang, Kebing Chen, Liyan Wang, Juhui Chen, Zhizhong Lin, Yuanmei Chen, Junqiang Chen, Yu Lin, Yuanji Xu, Haiyan Peng

https://doi.org/10.18632/aging.205012pp 8993—9021

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Causal relationship between Alzheimer’s disease and cardiovascular disease: a bidirectional Mendelian randomization analysis

Fengjun Zhang, Dexian Xian, Junchen Feng, Luning Ning, Tianshou Jiang, Wenchang Xu, Yuan Liu, Qiong Zhao, Min Peng

https://doi.org/10.18632/aging.205013pp 9022—9040

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Galectin-3 promotes brain injury by modulating the phenotype of microglia via binding TLR-4 after intracerebral hemorrhage

Tianyu Liang, Zheng Zhu, Fangxiao Gong, Xiaobo Yang, Xiaoju Lei, Ling Lu

https://doi.org/10.18632/aging.205014pp 9041—9058

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Prognostic and immunological roles of IL18RAP in human cancers

Wu Chen, Tianbao Song, Fan Zou, Yuqi Xia, Ji Xing, Weimin Yu, Ting Rao, Xiangjun Zhou, Chenglong Li, Jinzhuo Ning, Sheng Zhao, Yuan Ruan, Fan Cheng

https://doi.org/10.18632/aging.205017pp 9059—9085

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Integrated clustering signature of genomic heterogeneity, stemness and tumor microenvironment predicts glioma prognosis and immunotherapy response

Yangyang Wu, Meng Mao, Lin-Jian Wang

https://doi.org/10.18632/aging.205018pp 9086—9104

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Gut microbiota and hypertensive disorders in pregnancy: evidence from the Mendelian randomization study

Xinrui Wu, Qi Li, Dihui Lin, Jiawang Cai, Houxiang Huang, Hongzhuan Tan

https://doi.org/10.18632/aging.205019pp 9105—9127

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Long-term aspirin administration suppresses inflammation in diabetic cystopathy

Huifang Du, Feihong Xu, Jingxuan Liu, Jiakui Zhang, Yinhua Qin, Youqian Xu, Ning Li

https://doi.org/10.18632/aging.205021pp 9128—9143

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Prognostic significance and immune characteristics of GPR27 in gastric cancer

Jun Pan, Yuanjun Gao

https://doi.org/10.18632/aging.205023pp 9144—9166

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Human adipose-derived stem cells preconditioned with a novel herbal formulation Jing Shi attenuate doxorubicin-induced cardiac damage

Dennis Jine-Yuan Hsieh, Bruce Chi-Kang Tsai, Parthasarathi Barik, Marthandam Asokan Shibu, Chia-Hua Kuo, Wei-Wen Kuo, Pi-Yu Lin, Cheng-Yen Shih, Shinn-Zong Lin, Tsung-Jung Ho, Chih-Yang Huang

https://doi.org/10.18632/aging.205026pp 9167—9181

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