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Research Paper|Volume 15, Issue 17|pp 8930—8947

A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma

Tianyu Wang1,3, Kang Xia1,3, Tao Qiu1,2, Shangting Han1,2, Zhongbao Chen1,2, Xiaoxiong Ma1,2, Long Zhang1,2, Jilin Zou1,2, Yalong Zhang1,2, Bo Yu1,2, Chenyang Kong1,2, Jiayu Guo1,2, Yiting Liu1,2, Jiangqiao Zhou1,2, Shusen Zheng1,4,5,6,7
  • 1Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan, China
  • 2Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China
  • 3Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, China
  • 4Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
  • 5NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou, China
  • 6Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic Cancer, Chinese Academy of Medical Sciences (2019RU019), Hangzhou, China
  • 7Key Laboratory of Organ Transplantation, Research Center for Diagnosis and Treatment of Hepatobiliary Diseases, Hangzhou 310003, Zhejiang, China
* Equal contribution and co-first authors
Received: May 1, 2023Accepted: August 20, 2023Published: September 8, 2023
https://doi.org/10.18632/aging.205008

Copyright: © 2023 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Hepatocellular carcinoma (HCC) is the most common subtype, accounting for about 90% of all primary liver cancers. The liver is rich in a large number of immune cells, thus forming a special immune microenvironment, which plays a key role in the occurrence and development of hepatocellular carcinoma. Nowadays, tumor immunotherapy has become one of the most promising cancer treatment methods. Immune checkpoint inhibitors (ICIs) combined with VEGF inhibitors are listed as first-line treatment options for advanced HCC. Therefore, the search for a potential biomarker to predict the response to immunotherapy in HCC patients is urgently needed. The G protein-coupled receptor 55 (GPR55), a lysophosphatidylinositol (LPI) receptor, has recently emerged as a potential new target for anti-tumor therapy. Previous studies have found that GPR55 is highly expressed in breast cancer, pancreatic cancer, skin cancer and cholangiocarcinoma, and is involved in tumor proliferation and migration. However, the role and mechanism of GPR55 in HCC has not been elucidated. Therefore, this article discusses the clinical significance of GPR55 in HCC and its correlation with the immune response of HCC patients, so as to provide theoretical basis for improving the prognosis of HCC.