Volume 15, Issue 10

31 May, 2023
pp 3893—4565

About the Cover

The cover features Figure 1 "eCLIP-seq of G3BP1 and G3BP2 in SH-SY5Y cells under normal conditions" from Sato et al.

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Editorials

Reference genes in aging: what are you referring to?

Manish Mishra, Susan E. Howlett,

https://doi.org/10.18632/aging.204710 pp 3893—3895

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More than a loading control: actin regulation in aging

Maxim Averbukh, Gilberto Garcia, Ryo Higuchi-Sanabria,

https://doi.org/10.18632/aging.204746 pp 3896—3898

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Elderly CD8⁺ T cells in the focus for immunotherapeutic approaches

Annette Lis, Dorina Zöphel,

https://doi.org/10.18632/aging.204747 pp 3899—3900

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Aging gracefully: time and space matter

Charline Roy, Laurent Molin, Florence Solari,

https://doi.org/10.18632/aging.204773 pp 3901—3903

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Research Papers

DNAmFitAge: biological age indicator incorporating physical fitness

Kristen M. McGreevy, Zsolt Radak, Ferenc Torma, Matyas Jokai, Ake T. Lu, Daniel W. Belsky, Alexandra Binder, Riccardo E. Marioni, Luigi Ferrucci, Ewelina Pośpiech, Wojciech Branicki, Andrzej Ossowski, Aneta Sitek, Magdalena Spólnicka, Laura M. Raffield, Alex P. Reiner, Simon Cox, Michael Kobor, David L. Corcoran, Steve Horvath,

https://doi.org/10.18632/aging.204538 pp 3904—3938

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Circulating immune cell phenotypes are associated with age, sex, CMV, and smoking status in the Framingham Heart Study offspring participants

Yuan Fang, Margaret F. Doyle, Jiachen Chen, Jesse Mez, Claudia L. Satizabal, Michael L. Alosco, Wei Qiao Qiu, Kathryn L. Lunetta, Joanne M. Murabito,

https://doi.org/10.18632/aging.204686 pp 3939—3966

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Vascular endothelial growth factor receptor 1 gene (FLT1) longevity variant increases lifespan by reducing mortality risk posed by hypertension

Brian J. Morris, Randi Chen, Timothy A. Donlon, Kalpana J. Kallianpur, Kamal H. Masaki, Bradley J. Willcox,

https://doi.org/10.18632/aging.204722 pp 3967—3983

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Stress granules sequester Alzheimer’s disease-associated gene transcripts and regulate disease-related neuronal proteostasis

Kaoru Sato, Ken-ichi Takayama, Satoshi Inoue,

https://doi.org/10.18632/aging.204737 pp 3984—4011

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Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex

Renuka Kandhaya-Pillai, Francesc Miro-Mur, Jaume Alijotas-Reig, Tamar Tchkonia, Simo Schwartz, James L. Kirkland, Junko Oshima,

https://doi.org/10.18632/aging.204743 pp 4012—4034

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Changes in macrophage immunometabolism as a marker of skeletal muscle dysfunction across the lifespan

Norika Liu, Joshua T. Butcher, Atsushi Nakano, Andrea del Campo,

https://doi.org/10.18632/aging.204750 pp 4035—4050

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Integrating machine learning and bioinformatics analysis to m6A regulator-mediated methylation modification models for predicting glioblastoma patients’ prognosis and immunotherapy response

Chuanyu Li, Wangrui Liu, Chengming Liu, Qisheng Luo, Kunxiang Luo, Cuicui Wei, Xueyu Li, Jiancheng Qin, Chuanhua Zheng, Chuanliu Lan, Shiyin Wei, Rong Tan, Jiaxing Chen, Yuanbiao Chen, Huadong Huang, Gaolian Zhang, Haineng Huang, Xiangyu Wang,

https://doi.org/10.18632/aging.204495 pp 4051—4070

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lncRNA PITPNA-AS1 promotes cell proliferation and metastasis in hepatocellular carcinoma by upregulating PDGFD

Jianguo Yao, Xiaojian Liu,

https://doi.org/10.18632/aging.204566 pp 4071—4083

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Xuesaitong promotes myocardial angiogenesis in myocardial infarction mice by inhibiting MiR-3158-3p targeting Nur77

Jiangquan Liao, Mingjing Shao, Yan Wang, Peng Yang, Dongliang Fu, Mengru Liu, Tong Gao, Kangkang Wei, Xianlun Li, Jinhang Du,

https://doi.org/10.18632/aging.204671 pp 4084—4095

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Cadmium-induced impairment of spermatozoa development by reducing exosomal-MVBs secretion: a novel pathway

Waseem Ali, Yusheng Bian, Hina Ali, Jian Sun, Jiaqiao Zhu, Yonggang Ma, Zongping Liu, Hui Zou,

https://doi.org/10.18632/aging.204675 pp 4096—4107

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Association of NCAP family genes with prognosis and immune infiltration of human sarcoma

Guangyao Jiang, Qunyan Tian, Peikai Shi, Zhigao Li, Yan Li, Junjie Chen, Wanchun Wang, Ruiqi Chen, Hua Zhong, Gen Wu,

https://doi.org/10.18632/aging.204683 pp 4108—4121

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PCNT is a prognostic biomarker correlated with tumor immune microenvironment in hepatocellular carcinoma and promotes tumor progression by inhibiting cell cycle arrest

Xuyang Wang, Jinran Yang, Laibang Luo, Xinchang Li, Youfu Zhang,

https://doi.org/10.18632/aging.204711 pp 4122—4143

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Mechanisms of human umbilical cord mesenchymal stem cells-derived exosomal lncRNA GAS5 in alleviating EMT of HPMCs via Wnt/β-catenin signaling pathway

Yuling Huang, Jianfei Ma, Yi Fan, Lina Yang,

https://doi.org/10.18632/aging.204719 pp 4144—4158

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Characteristic of molecular subtypes based on PANoptosis-related genes and experimental verification of hepatocellular carcinoma

Haitao Ren, Na Kang, Shuan Yin, Chen Xu, Tengfei Qu, Dongdong Dai,

https://doi.org/10.18632/aging.204720 pp 4159—4181

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Sig1R activates extracellular matrix-induced bladder cancer cell proliferation and angiogenesis by combing β-integrin

Feng Zhao, Tianli Yang, Liuhua Zhou, Rongfei Li, Jingyu Liu, Jun Zhao, Ruipeng Jia,

https://doi.org/10.18632/aging.204721 pp 4182—4201

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Identification of fatty acid-related subtypes, the establishment of a prognostic signature, and immune infiltration characteristics in lung adenocarcinoma

Yuzhi Wang, Xiaoxiao Huang, Hong Fan, Yunfei Xu, Zelin Qi, Yi Zhang, Yi Huang,

https://doi.org/10.18632/aging.204725 pp 4202—4235

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Identification and validation of oxeiptosis-associated lncRNAs and prognosis-related signature genes to predict the immune status in uterine corpus endometrial carcinoma

Linjun Niu, Zhengyuan Wu,

https://doi.org/10.18632/aging.204726 pp 4236—4252

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Effectiveness of non-pharmaceutical intervention on sperm quality: a systematic review and network meta-analysis

Zilong Chen, Zhiming Hong, Shengjie Wang, Junfeng Qiu, Quan Wang, Yangling Zeng, Haowei Weng,

https://doi.org/10.18632/aging.204727 pp 4253—4268

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Systematic pan-cancer analysis identifies cuproptosis-related gene DLAT as an immunological and prognostic biomarker

Lidong Xu, Peipei Wu, Aimei Rong, Kunkun Li, Xingguo Xiao, Yong Zhang, Huili Wu,

https://doi.org/10.18632/aging.204728 pp 4269—4287

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DNMT1 regulates polarization of macrophage-induced intervertebral disc degeneration by modulating SIRT6 expression and promoting pyroptosis in vivo

Yang Hou, Jiangang Shi, Yongfei Guo, Guodong Shi,

https://doi.org/10.18632/aging.204729 pp 4288—4303

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Integrated network findings reveal ubiquitin-specific protease 44 overexpression suppresses tumorigenicity of liver cancer

Huanhuan Zhou, Lu Yang, Xiao Lin, Ting Fung Chan, Nikki Pui-Yue Lee, William Ka Fai Tse, Xing Zhang, Rong Li, Keng Po Lai,

https://doi.org/10.18632/aging.204733 pp 4304—4318

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Plasticity of adipose tissues in response to fasting and refeeding declines with aging in mice

Ya-Ru Chen, Fen Xiao, Hao-Neng Tang, Ting Wang, Ying-Hui Zhou, Junaid Iqbal, Shui-Bing Yang, Long Li, Houde Zhou,

https://doi.org/10.18632/aging.204734 pp 4319—4333

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Plasma exosome proteomics reveals the pathogenesis mechanism of post-stroke cognitive impairment

Baoyun Qi, Lingbo Kong, Xinxing Lai, Linshuang Wang, Fei Liu, Weiwei Ji, Dongfeng Wei,

https://doi.org/10.18632/aging.204738 pp 4334—4362

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PCSK6 mediates Th1 differentiation and promotes chronic colitis progression and mucosal barrier injury via STAT1

Xiaoping Mei, Hongkun Zhou, Zhengwei Song, Xiaodan Yang, Xiaorong Liu, Jianguo Fei, Yiyu Shen, Xiaoguang Wang,

https://doi.org/10.18632/aging.204739 pp 4363—4373

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Xuebijing injection protects against sepsis-induced myocardial injury by regulating apoptosis and autophagy via mediation of PI3K/AKT/mTOR signaling pathway in rats

Cheng-Fei Bi, jia Liu, Shao-Wen Hao, Zhi-Xia Xu, Xiao Ma, Xiang-Fei Kang, Li-Shan Yang, Jun-Fei Zhang,

https://doi.org/10.18632/aging.204740 pp 4374—4390

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Hairy gene homolog increases nasopharyngeal carcinoma cell stemness by upregulating Bmi-1

Ye Lei, Hong-Fen Shen, Qi-Wen Li, Sheng Yang, Hong-Ting Xie, Xu-Feng Li, Mei-Ling Chen, Jia-Wei Xia, Sheng-Chun Wang, Guan-Qi Dai, Ying Zhou, Ying-Chun Li, Shi-Hao Huang, Dan-Hua He, Zhi-Hao Zhou, Jin-Ge Cong, Xiao-Lin Lin, Tao-Yan Lin, Ai-Bing Wu, Dong Xiao, Sheng-Jun Xiao, Xin-Ke Zhang, Jun-Shuang Jia,

https://doi.org/10.18632/aging.204742 pp 4391—4410

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Brevilin A shows an anti-tumor role in prostate cancer via the lncRNA H19/miR-194/E2F3 signaling pathway

Pinghong You, Liangyou Tang, Yanjie Zhu, Yuchang Tian,

https://doi.org/10.18632/aging.204744 pp 4411—4428

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Metformin inhibits ovarian granular cell pyroptosis through the miR-670-3p/NOX2/ROS pathway

Li-Hua Zhou, Hui Zou, Jia-Yuan Hao, Yong Huang, Jia-Nan Zhang, Xiao-Hong Xu, Juan Li,

https://doi.org/10.18632/aging.204745 pp 4429—4443

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Development and validation of a novel T cell proliferation-related prognostic model for predicting survival and immunotherapy benefits in melanoma

Jiajie Chen, Daiyue Wang, Shixin Chan, Qingqing Yang, Chen Wang, Xu Wang, Rui Sun, Yu Gui, Shuling Yu, Jinwei Yang, Haoxue Zhang, Xiaomin Zhang, Kechao Tang, Huabing Zhang, Shengxiu Liu,

https://doi.org/10.18632/aging.204748 pp 4444—4464

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Identification and validation of diagnostic signature genes in non-obstructive azoospermia by machine learning

Lingxiang Ran, Zhixiang Gao, Qiu Chen, Fengmei Cui, Xiaolong Liu, Boxin Xue,

https://doi.org/10.18632/aging.204749 pp 4465—4480

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Effects of remote ischemic postconditioning on the pro-inflammatory neutrophils of peripheral blood in acute cerebral infarction

Zhen Liang, Lin Qiu, Xu Wang, Liangshu Feng, Yulei Hao, Feng Yang, Di Ma, Jiachun Feng,

https://doi.org/10.18632/aging.204751 pp 4481—4497

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Expression of αA-crystallin (CRYAA) in vivo and in vitro models of age-related cataract and the effect of its silencing on HLEB3 cells

Xiaoling Ma, Yi Nan, Can Huang, Xiangyang Li, Yifan Yang, Wenjie Jiang, Mengyi Ye, Qian Liu, Yang Niu, Ling Yuan,

https://doi.org/10.18632/aging.204754 pp 4498—4509

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lncRNA PCBP1-AS1 mediated downregulation of ITGAL as a prognostic biomarker in lung adenocarcinoma

Qiang Wang, GuangJun Xiao, Na Li, Xiulin Jiang, Chunhong Li,

https://doi.org/10.18632/aging.204756 pp 4510—4523

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Triterpene acid from Antrodia camphorata alleviates inflammation in acute liver injury

Chenxi Cao, Hai Zhong, Zhenwei Chen, Zhengwei Song, Biwen Hu, Xiaoguang Wang,

https://doi.org/10.18632/aging.204757 pp 4524—4532

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Glycolytic regulatory enzyme PFKFB3 as a prognostic and tumor microenvironment biomarker in human cancers

Qingen Da, Lei Huang, Can Huang, Zee Chen, Zhitong Jiang, Fang Huang, Tao Shen, Lu Sun, Zilong Yan, Xiaoqiang Ye, Jing Yi, Yu Huang, JingJing Da, Mingming Ren, Jikui Liu, Tao Wang, Zhen Han, Kunfu Ouyang,

https://doi.org/10.18632/aging.204758 pp 4533—4559

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Corrections

Correction for: Long intergenic non-protein coding RNA 324 prevents breast cancer progression by modulating miR-10b-5p

Bo Wang, Yangyang Zhang, Haitian Zhang, Faquan Lin, Qixin Tan, Qinghong Qin, Wei Bao, Yi Liu, Jiaying Xie, Qiyan Zeng,

https://doi.org/10.18632/aging.204784 pp 4560—4562

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Correction for: Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation

Chen Yang, Qiong Li, Xinan Chen, Zheyu Zhang, Zezhong Mou, Fangdie Ye, Shengming Jin, Xiang Jun, Feng Tang, Haowen Jiang,

https://doi.org/10.18632/aging.204791 pp 4563—4565

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