Research Paper|Volume 15, Issue 10|pp 4524—4532

Triterpene acid from Antrodia camphorata alleviates inflammation in acute liver injury

Chenxi Cao¹, Hai Zhong¹, Zhenwei Chen¹, Zhengwei Song¹, Biwen Hu¹, Xiaoguang Wang¹

¹Department of Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314001, Zhejiang, China

* Co first-author

Received: March 8, 2023Accepted: May 17, 2023Published: May 26, 2023

https://doi.org/10.18632/aging.204757

Copyright: © 2023 Cao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This study aimed to investigate the role and mechanism of Anctin A, the Antrodia camphorata terpene component, in resisting liver injury. Network pharmacology analysis revealed that MAPK3 was the major action target of Antcin A. Furthermore, experimental research suggested that Antcin A suppressed mouse liver injury, reduced the inflammatory factor levels, and enhanced the anti-oxidative capacity. Meanwhile, it suppressed the expression of MAPK3 and the downstream NF-κB signal, while it did not significantly affect the expression of MAPK1. Based on network pharmacology method, this study discovers that the anti-liver injury effect of Antcin A is mainly related to MAPK3, and that Antcin A can suppress the activation of MAPK3 and its downstream NF-κB to inhibit mouse ALI.