Effects of Resveratrol on Circadian Clock Gene Expression in Young and Older Human Cells
01-15-2024“This study reflects transdisciplinary efforts to link aging and circadian biology in human-derived tissues, which is an understudied area of biology.”
Listen to an audio version of this press release
BUFFALO, NY- January 15, 2024 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 1, entitled, “Effects of resveratrol on in vitro circadian clock gene expression in young and older human adipose-derived progenitor cells.”
Observational studies in preclinical models demonstrate age-related declines in circadian functions. In this new study, researchers Sophie G.C. Kapar, Maria F. Pino, Fanchao Yi, Miguel A. Gutierrez-Monreal, Karyn A. Esser, Lauren M. Sparks, and Melissa L. Erickson from AdventHealth and the University of Florida hypothesized that age would be associated with declines in function of cell-autonomous circadian clocks in human tissue.
“Accordingly, we cultured adipose progenitor cells (APCs) from previously collected white-adipose tissue biopsies from abdominal subcutaneous depots of young (Age: 23.4 ± 2.1 yrs) vs. older female participants (Age: 70.6 ± 5.9 yrs).”
Using an in vitro model, the researchers compared rhythmic gene expression profiles of core clock components, as an indicator of circadian oscillatory function. They observed consistent circadian rhythmicity of core clock components in young and older-APCs. Expression analysis showed increased levels of some components in older-APCs (CLOCK, CRY1, NR1D1) vs. young.
The team also investigated resveratrol (RSV), a well-known longevity-enhancing effector, for its effects on rhythmic clock gene expression profiles. They found that RSV resulted in gained rhythmicity of some components (CLOCK and CRY), loss of rhythmicity in others (PER2, CRY2), and altered some rhythmic parameters (NR1D1 and NR1D2), consistent in young and older-APCs. The observation of detectable circadian rhythmicity retained in vitro suggests that the oscillatory function of the cell-autonomous core clock in APCs is preserved at this stage of the aging process.
“RSV impacts core clock gene expression in APCs, implicating its potential as a therapeutic agent for longevity by targeting the core clock.”
Read the full study: DOI:https://doi.org/10.18632/aging.205292
Corresponding Authors: Lauren M. Sparks, Melissa L. Erickson - Lauren.Sparks@AdventHealth.com, Melissa.L.Erickson@AdventHealth.com
Keywords: circadian clock, circadian rhythm, aging, adipose-derived progenitor cells, resveratrol
Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205292
About Aging-US:
Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.
Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).
Please visit our website at www.Aging-US.com and connect with us:
- X
- YouTube
- Spotify, Apple, SoundCloud, and available wherever you listen to podcasts
For media inquiries, please contact media@impactjournals.com.